Differentiated Mesenchymal Stem Cells for Sciatic Nerve Injury

Dadon-Nachum, Michal; Sadan, Ofer; Srugo, I.; Melamed, Eldad; Offen, Daniel

doi:10.1007/s12015-010-9227-1

Cited by 55 publications

(36 citation statements)

References 39 publications

(78 reference statements)

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“…With further refinement, it may become possible to sustain regenerative support through regular systemic dosing. There is also evidence that stem cells may be efficacious when administered at the level of neuromuscular junction (NMJ) ( Figure 2F) or when distributed within denervated muscle [76,77,167] .…”

Section: Cell Scaffolds and Methods Of Deliverymentioning

confidence: 99%

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn

Meppelink

Ng-Glazier

et al. 2015

WJSC

124

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Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell (SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration.

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Section: Cell Scaffolds and Methods Of Deliverymentioning

confidence: 99%

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn

Meppelink

Ng-Glazier

et al. 2015

WJSC

124

View full text Add to dashboard Cite

show abstract

“…This intracellular "GABA-glutamate-glutamine cycle" is maintained for normal physiological homeostasis. Hyperexcitable neurons and and its important role in nerve healing and regeneration (33,34), and considering the valuable effect of grow factors such as TGF-β1, alleviating early-and late-phase neuropathic pain symptoms, such as allodynia and hyperalgesia (17).…”

Section: Alterations Of the Gamma Aminobutiric Acid (Gaba) Inhibitionmentioning

confidence: 99%

Platelet-rich plasma in treating peripheral neuropathic pain. Preliminary report

Lopez¹,

Cortes²,

García-Ceballos³

et al. 2017

Rev. Soc. Esp. Dolor.

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“…These and other mesenchymal stem cell-released factors simultaneously act directly on axons to induce and promote their regeneration [28,221]. Finally, mesenchymal stem cells also promote enhanced axon regeneration by their release of neurotrophic factors, such as CNTF, PDGF-alpha, LIF, beta-NGF, TGF-beta1, BDNF, and β-FGF, but not NT-3 and NT-4 [272][273][274][275][276][277], and axon guidance and neural cell adhesion molecules, such as ECM components [273,278] that act directly on axons to promote their regeneration. This can be demonstrated by applying mesenchymal stem cells to the end of a transected nerve [221,279] and their addition to acellular nerves or into empty nerve conduits bridging nerve gaps [280][281][282].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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Platelet-rich plasma (PRP) has been tested in vitro, in animal models, and clinically for its efficacy in enhancing the rate of wound healing, reducing pain associated with injuries, and promoting axon regeneration. Although extensive data indicate that PRP-released factors induce these effects, the claims are often weakened because many studies were not rigorous or controlled, the data were limited, and other studies yielded contrary results. Critical to assessing whether PRP is effective are the large number of variables in these studies, including the method of PRP preparation, which influences the composition of PRP; type of application; type of wounds; target tissues; and diverse animal models and clinical studies. All these variables raise the question of whether one can anticipate consistent influences and raise the possibility that most of the results are correct under the circumstances where PRP was tested. This review examines evidence on the potential influences of PRP and whether PRP-released factors could induce the reported influences and concludes that the preponderance of evidence suggests that PRP has the capacity to induce all the claimed influences, although this position cannot be definitively argued. Well-defined and rigorously controlled studies of the potential influences of PRP are required in which PRP is isolated and applied using consistent techniques, protocols, and models. Finally, it is concluded that, because of the purported benefits of PRP administration and the lack of adverse events, further animal and clinical studies should be performed to explore the potential influences of PRP.

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Differentiated Mesenchymal Stem Cells for Sciatic Nerve Injury

Cited by 55 publications

References 39 publications

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Platelet-rich plasma in treating peripheral neuropathic pain. Preliminary report

Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

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