Differentially regulated microRNAs during human sebaceous lipogenesis

Schneider, Marlon R.; Samborski, Anastazia; Bauersachs, Stefan; Zouboulis, Christos C.

doi:10.1016/j.jdermsci.2013.01.009

Cited by 24 publications

(19 citation statements)

References 41 publications

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“…In contrast, PLIN3 downregulation significantly reduced lipid accumulation after 48 h of culture in medium containing linoleic acid (LA, Fig. 1b), an essential fatty acid (FA) frequently employed for inducing lipid synthesis in sebocytes (25)(26)(27). Importantly, PLIN3 downregulation did not affect cell proliferation (not shown).…”

Section: Resultsmentioning

confidence: 92%

Perilipin 3 modulates specific lipogenic pathways in SZ95 sebocytes

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Dahlhoff²,

Ludovici

et al. 2014

Experimental Dermatology

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In recent years, the scientific community has generated an ever-increasing amount of data from a growing number of animal models of human cancers. Much of these data come from genetically engineered mouse models. Identifying appropriate models for skin cancer and related relevant genetic data sets from an expanding pool of widely disseminated data can be a daunting task. The Mouse Tumor Biology Database (MTB) provides an electronic archive, search and analysis system that can be used to identify dermatological mouse models of cancer, retrieve modelspecific data and analyse these data. In this report, we detail MTB's contents and capabilities, together with instructions on how to use MTB to search for skin-related tumor models and associated data.

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Section: Resultsmentioning

confidence: 92%

Perilipin 3 modulates specific lipogenic pathways in SZ95 sebocytes

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Dahlhoff²,

Ludovici

et al. 2014

Experimental Dermatology

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“…[130]. Interestingly, during sebaceous lipogenesis differentially regulated microRNAs could be detected [131].…”

Section: Antimicrobial Peptidesmentioning

confidence: 98%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

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The sebaceous gland is mostly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland central role in acne pathogenesis, early research had focused on its lipogenic activity. Less-studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin and skin aging have recently attracted the attention of researchers from different disciplines. Here, we summarize recent, multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.

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“…LA is an essential fatty acid (FA) frequently employed for inducing lipid synthesis in sebocytes [51][52][53]. Analysis of the cells with an automated imaging system (Operetta) revealed a 2.5-fold increase in the number of LDs/cell (Fig.…”

Section: Evaluation Of Lipid Accumulationmentioning

confidence: 99%