Differentially expressed long-chain noncoding RNAs in human neuroblastoma cell line (SH-SY5Y): Alzheimer’s disease cell model

Zhang, Ming; Zhang, Yuanqing; Wei, Xie-Ze; Lee, Charles; Huo, Dong-Sheng; Wang, He; Zhong, Zhao

doi:10.1080/15287394.2019.1687183

Cited by 9 publications

(11 citation statements)

References 27 publications

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“…Mice were used as the model in 36 animal studies, and zebrafish was used in one study. There are 16 different cell lines used in these studies, including SH-SY5Y in 16 studies (Massone et al, 2011 ; Vaure and Liu, 2014 ; Huang et al, 2017 , 2020 ; Cai et al, 2018 ; Li H. et al, 2018 ; Ke et al, 2019 ; Ma et al, 2019 ; Wang X. et al, 2019 ; Zeng et al, 2019 ; Zhang M. et al, 2019 ; Chen et al, 2020 ; Qasim et al, 2020 ; Wang Q. et al, 2020 ; Xu et al, 2020 ; Yan et al, 2020 ; Zhao et al, 2020 ; Zhou Y. et al, 2020 ; Zhang and Wang, 2021 ), HEK293 in 12 studies (Faghihi et al, 2008 ; Cai et al, 2017 ; Ghanbari et al, 2019 ; Ke et al, 2019 ; Zeng et al, 2019 ; Zhang et al, 2019 ; Zhu et al, 2019 ; Ge et al, 2020 ; Huang et al, 2020 ; Zhou B. et al, 2020 ; Zhang and Wang, 2021 ), PC12 in seven studies (Guo et al, 2018 ; Wang J. et al, 2018 ; Ma et al, 2019 ; Zhao et al, 2019 ; Bastard et al, 2020 ; Zhou B. et al, 2020 ; Zhang et al, 2021 ), SK-N-SH in 5 studies (Ke et al, 2019 ; Gao et al, 2020 ; Ge et al, 2020 ; He et al, 2020 ; Xu et al, 2020 ), N2A in five studies (Cai et al, 2017 ; Li D. et al, 2018 ; Butler et al, 2019 ; Huang et al, 2020 ; Yue et al, 2020 ), U251 in two studies (Lin et al, 2019 ; Zeng et al, 2019 ), Human peripheral neurons (HPNs) in two studies (Zeng et al, 2019 ; Ge et al, 2020 ), SK-N-F1 (Kang et al, 2014 ), RAW264.7 (Yamanaka et al, 2015 ), Hela (Spreafico et al, 2018 ), CHP212 (Gao et al, 2020 ...…”

Section: Resultsmentioning

confidence: 99%

“…Due to the large volume of methods and tests performed in these studies, only the major methods are mentioned. The distribution of studies is limited to only seven countries, in which China with 54 studies has a significant share (Vaure and Liu, 2014 ; Luo et al, 2015 ; Zhang et al, 2016 , 2021 ; Cai et al, 2017 , 2018 ; Deng et al, 2017 ; Fang et al, 2017 ; Huang et al, 2017 , 2020 ; Yang et al, 2017 ; Feng et al, 2018 ; Guo et al, 2018 ; Li D. et al, 2018 ; Li H. et al, 2018 ; Liu et al, 2018 ; Wang J. et al, 2018 ; Wang X. et al, 2018 , 2019 ; Zhang T. et al, 2018 ; Ke et al, 2019 ; Lin et al, 2019 ; Ma et al, 2019 , 2020 ; Tang et al, 2019 ; Yi et al, 2019 ; Zeng et al, 2019 ; Zhang M. et al, 2019 ; Zhu et al, 2019 ; Bastard et al, 2020 ; Chen et al, 2020 ; Gao et al, 2020 ; Ge et al, 2020 ; He et al, 2020 ; Hong et al, 2020 ; Li et al, 2020 ; Qasim et al, 2020 ; Wang D. et al, 2020 ; Wang Q. et al, 2020 ; Xu et al, 2020 ; Yan et al, 2020 ; Yue et al, 2020 ; Zhao et al, 2020 ; Zhou B. et al, 2020 ; Zhou Y. et al, 2020 ; Zhuang et al, 2020 ; Zhang and Wang, 2021 ), followed by the United States with five studies (Faghihi et al, 2008 ; Airavaara et al, 2011 ; Kang et al, 2014 ; Yamanaka et al, 2015 ; Butler et al, 2019 ), Iran (Azizi-Aghaali et al, 2018 ; Fotuhi et al, 2019 ; Azadfar et al, 2020 ), and Italy (Massone et al, 2011 ; Spreafico et al,…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Cell culture, animal study 26. 4% Li D. et al, 2018;Wang X. et al, 2018;Butler et al, 2019;Lin et al, 2019;Ma et al, 2019;Zeng et al, 2019;Bastard et al, 2020;Hong et al, 2020;Huang et al, 2020;Li et al, 2020;Qasim et al, 2020;Yan et al, 2020;Yue et al, 2020;Zhao et al, 2020;Zhou B. et al, 2020 Cell culture 23.5% Vaure and Liu, 2014;Cai et al, 2018;Ke et al, 2019;Ma et al, 2019;Wang X. et al, 2019;Zeng et al, 2019;Zhang M. et al, 2019;Zhu et al, 2019;Chen et al, 2020;Gao et al, 2020;Ge et al, 2020;Gu et al, 2020;Xu et al, 2020;Zhou B. et al, 2020 Case-control 14.7% Luo et al, 2015;Deng et al, 2017;Azizi-Aghaali et al, 2018;Feng et al, 2018;Guo et al, 2018;Fotuhi et al, 2019;Garofalo et al, 2020;Kurt et al, 2020;Wang D. et al, 2020;Zhuang et al, 2020 Animal study 13.2% Zhang et al, 2016;Fang et al, 2017;Yang et al, 2017;…”

Section: Type Of Studies Percentage Referencesunclassified

See 3 more Smart Citations

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Asadi

Hassani

Kiani

et al. 2021

Front. Aging Neurosci.

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LncRNAs act as part of non-coding RNAs at high levels of complex and stimulatory configurations in basic molecular mechanisms. Their extensive regulatory activity in the CNS continues on a small scale, from the functions of synapses to large-scale neurodevelopment and cognitive functions, aging, and can be seen in both health and disease situations. One of the vast consequences of the pathological role of dysregulated lncRNAs in the CNS due to their role in a network of regulatory pathways can be manifested in Alzheimer's as a neurodegenerative disease. The disease is characterized by two main hallmarks: amyloid plaques due to the accumulation of β-amyloid components and neurofibrillary tangles (NFT) resulting from the accumulation of phosphorylated tau. Numerous studies in humans, animal models, and various cell lines have revealed the role of lncRNAs in the pathogenesis of Alzheimer's disease. This scoping review was performed with a six-step strategy and based on the Prisma guideline by systematically searching the publications of seven databases. Out of 1,591 records, 69 articles were utterly aligned with the specified inclusion criteria and were summarized in the relevant table. Most of the studies were devoted to BACE1-AS, NEAT1, MALAT1, and SNHG1 lncRNAs, respectively, and about one-third of the studies investigated a unique lncRNA. About 56% of the studies reported up-regulation, and 7% reported down-regulation of lncRNAs expressions. Overall, this study was conducted to investigate the association between lncRNAs and Alzheimer's disease to make a reputable source for further studies and find more molecular therapeutic goals for this disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Type Of Studies Percentage Referencesunclassified

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The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Asadi

Hassani

Kiani

et al. 2021

Front. Aging Neurosci.

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“…Malal1 has also been speculated to be an Nrf2 regulator which is part of a protein complex of the cellular oxidative response and a target that alters oxidative stress through miRNA [53]. Moreover, in recent years, oxidative stress was shown to correlate strongly with lncRNAs expression [54,55]. Among the lncRNAs that are highly expressed is the oxidative stress-dependent Neat1.…”

Section: A Coordinated Suppression Of Er Chaperones and Folding Enzymes By A Chronic Oxidative Stressmentioning

confidence: 99%

Ladostigil attenuates the oxidative and ER stress in human neuroblast-like SH-SY5Y cells

Zohar

Lezmi

Eliyahu

et al. 2021

Preprint

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A hallmark of the aging brain is the robust inflammation mediated by microglial activation. Neuroinflammation resulting from the induction of oxidative stress in neurodegenerative diseases and following brain injury. Chronic treatment of aging rats by ladostigil, a compound with antioxidant and anti-inflammatory function, prevented microglial activation and learning deficits. In this study, we investigate the effect of ladostigil on neuronal-like SH-SY5Y cells. We show that SH-SY5Y cells exposed to acute (by H2O2) or chronic oxidative stress (by Sin1, 3-morpholinosydnonimine) induced apoptotic cell death. However, in the presence of ladostigil, the decline in cell viability and the oxidative levels were partially reversed. RNA-seq analysis showed that chronic oxidation by Sin1 resulted in coordinated suppression of endoplasmic reticulum (ER) quality control and ER stress response gene sets. Chronic oxidative stress impacted ER proteostasis and induced the expression of numerous lncRNAs. Pre-incubation with ladostigil before exposing SH-SY5Y cells to Sin1 induced Clk1 (Cdc2-like kinase 1) which was implicated in psychophysiological stress in mice and Alzheimer disease. Ladostigil also suppressed the expression of Ccpg1 (Cell cycle progression 1) and Synj1 (Synaptojanin 1) that function in ER-autophagy and endocytic pathways. We postulate that ladostigil alleviated cell damage by oxidation and ER stress. Therefore, it may attenuate neurotoxicity and cell death that accompany chronic stress conditions in the aging brain.

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A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease

Moayedi

Orandi

Ebrahimi

et al. 2022

Journal Cellular Physiology

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Today, growing evidence indicates that patients with type 2 diabetes (T2D) are at a higher risk of developing Alzheimer's disease (AD). Indeed, AD as one of the main causes of dementia in people aged more than 65 years can be aggravated by insulin resistance (IR) and other metabolic risk factors related to T2D which are also linked to the function of the brain. Remarkably, a new term called “type 3 diabetes” has been suggested for those people who are diagnosed with AD while also showing the symptoms of IR and T2D. In this regard, the role of genetic and epigenetic changes associated with AD has been confirmed by many studies. On the other hand, it should be noted that the insulin signaling pathway is highly regulated by various mechanisms, including epigenetic factors. Among these, the role of noncoding RNAs (ncRNAs), including microRNAs and long noncoding RNAs has been comprehensively studied with respect to the pathology of AD and the most well‐known underlying mechanisms. Nevertheless, the number of studies exploring the association between ncRNAs and the downstream targets of the insulin signaling pathway in the development of AD has notably increased in recent years. With this in view, the present study aimed to review the interplay between different ncRNAs and the insulin signaling pathway targets in the pathogenesis of AD to find a new approach in the field of combining biomarkers or therapeutic targets for this disease.

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Differentially expressed long-chain noncoding RNAs in human neuroblastoma cell line (SH-SY5Y): Alzheimer’s disease cell model

Cited by 9 publications

References 27 publications

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Ladostigil attenuates the oxidative and ER stress in human neuroblast-like SH-SY5Y cells

A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease

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