2001
DOI: 10.1073/pnas.231489198
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Differentially expressed late constituents of the epidermal cornified envelope

Abstract: Barrier activity of skin and internal barrier-forming epithelial linings are conferred by a lipid-corneocyte structure (stratum corneum in skin).The integrity of the corneocytes depends on the outer cornified envelope and is essential for maintenance of barrier function. During epidermal development and differentiation, proteins are sequentially incorporated into the envelope via action of epidermal transglutaminases in a well documented process. However, recent knockouts of major cornified envelope constituen… Show more

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Cited by 152 publications
(146 citation statements)
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“…20,21 Cytokeratin 13 (Tables 1 and 2) was found at high levels only in murine aorta. Other known CE precursor proteins, such as involucrin, filaggrin, elafin, annexin I, repetin, cystatin A, trichohyalin, and loricrin, 28 were not detected in murine aorta or IVC with the microarray analysis or by qRT-PCR (data not shown).…”
Section: Common Features Of Cornified Cell Envelope In Skin and Aortamentioning
confidence: 95%
“…20,21 Cytokeratin 13 (Tables 1 and 2) was found at high levels only in murine aorta. Other known CE precursor proteins, such as involucrin, filaggrin, elafin, annexin I, repetin, cystatin A, trichohyalin, and loricrin, 28 were not detected in murine aorta or IVC with the microarray analysis or by qRT-PCR (data not shown).…”
Section: Common Features Of Cornified Cell Envelope In Skin and Aortamentioning
confidence: 95%
“…PLA2 g (PLA2G4C), group IIF phospholipase (PLA2G2F) and group IIE phospholipase (PLA2G2E) induce the release of arachidonate from phospholipids. [15][16][17] LEP14 and LEP13 18 were predicted in silico to have PLA2 activity, and PATE bears a putative PLA2 motif. 19 Adiponutrin is similar to patatin-like phospholipase domain-containing protein 3 and also shows PLA2 activity.…”
Section: Lipases and Lipase Activity Associated Genes Are Overexpressmentioning
confidence: 99%
“…To confirm the expression levels of all genes identified in this analysis, Q-RT-PCR was performed on independently isolated samples (Table 1). Of the 28 genes identified as up-regulated in K5-Klf4 and Dex-treated mouse skin and down-regulated in Klf4 Ϫ/Ϫ mouse skin, 5 (Filaggrin, Lce2, Lce3, Lce5, and Lce7) map to the epidermal differentiation complex, a tandem array of genes encoding proteins that are cross-linked to form the proteinaceous component of the barrier (17). We have studied the coordinate gene regulation of the epidermal differentiation complex in Klf4 Ϫ/Ϫ mice (18).…”
Section: Identification Of Developmental Targets Of Corticosteroids Amentioning
confidence: 99%