Differentially expressed haptoglobin as a potential biomarker for type 2 diabetic mellitus in Hispanic population

Liu, Zhongwei; Du, Feng; Gu, Danshan; Zheng, Richard; Esperat, Christina; Gao, Weimin

doi:10.1002/biof.1352

Cited by 6 publications

(5 citation statements)

References 52 publications

(68 reference statements)

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“…It follows that haptoglobin 2 alleles have a higher risk of developing the disease. The studies of Spanish or Chinese population have led to similar conclusions [50,51]. They also showed that inherited factor such as the phenotype of haptoglobin may play an important role in the pathogenesis of type 2 diabetes.…”

Section: Discussionmentioning

confidence: 71%

Hp1-1 as a Genetic Marker Regulating Inflammation and the Possibility of Developing Diabetic Complications in Patients with Type 2 Diabetes—Cohort Studies

Stempkowska

Walicka

Franek

et al. 2020

Genes

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Background: This study assessed the influence of the haptoglobin phenotype on markers regulating inflammation in patients with type 2 diabetes. Methods: The haptoglobin phenotypes, soluble form of CD163 receptor (sCD163), p53 concentrations and high mobility group box protein 1 (HMGB1), interleukin 10 (IL-10) secretion in serum were assayed via ELISA tests. In the first part of the project, patients were divided into three groups which differed by the haptoglobin phenotype, and afterwards into two groups according to the criterion of the presence or absence of cardiovascular disease. Results: Diabetic patients with haptoglobin phenotype 1-1 (Hp1-1) had a significantly higher concentration of IL-10 and sCD163 compared to haptoglobin phenotype 2-1 (Hp2-1) and haptoglobin phenotype 2-2 (Hp2-2). Moreover, diabetic patients with Hp1-1 had a significantly lower concentration of p53 and HMGB1 compared to diabetic patients with Hp2-1 and Hp2-2. The results have shown that diabetics with Hp2-1 had a significantly lower postprandial glucose level compared to diabetics with Hp2-2. Apart from that, there were no differences in the occurrence of haptoglobin variants between patients with or without cardiovascular disease. Conclusions: Our study provides new data for a relationship between the type of haptoglobin in patients with type 2 diabetes and the concentration of factors that regulate the body’s inflammation. We have shown that the Hp1-1 can serve as a genetic marker of inflammatory processes.

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Section: Discussionmentioning

confidence: 71%

Hp1-1 as a Genetic Marker Regulating Inflammation and the Possibility of Developing Diabetic Complications in Patients with Type 2 Diabetes—Cohort Studies

Stempkowska

Walicka

Franek

et al. 2020

Genes

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“…Interestingly, haptoglobin (Hp) was more abundant in diabetic groups with poor glycemic control. Pooled serum samples from Hispanic T2DM subjects with HbA 1c ≥ 53 mmol/mol showed 1.5-fold higher Hp than those with HbA 1c < 53 mmol/mol [22]. In addition, diabetic patients with retinopathy increased plasma Hp more than 1.5-fold than those without retinopathy [11].…”

Section: Discussionmentioning

confidence: 87%

Prospection of plasma proteins as biomarkers for diabetes mellitus monitoring

Silva

Rego

Picheth

et al. 2021

J Diabetes Metab Disord

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Purpose This prospective study aimed to detect and identify plasma proteins differentially expressed between groups of Brazilian diagnosed with type 1 (T1DM), type 2 (T2DM) diabetes with good and poor glycemic control and the non-diabetic group denominated control group (CG). Methods Patients with T1DM and T2DM were subdivided according to their glycated haemoglobin (HbA 1c ) level: ≥ 53 mmol/ mol and < 53 mmol/mol. Each subgroup was composed of ten subjects (n = 10). The plasma from each subgroup was pooled and depleted of albumin and IgG. The reminiscent proteins were quantified and separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The relative volume of protein bands was determined by densitometry analysis, and those with differential abundance were identified by MALDI-TOF mass spectrometry. Results Alpha 2 -Macroglobulin (AMG) was 1.3-fold more abundant in T1DM with HbA 1c ≥ 53 mmol/mol and < 53 mmol/mol and 1.4-fold more abundant in T2DM with HbA 1c ≥ 53 mmol/mol compared to CG. Ceruloplasmin (Cp) and Haptoglobin (Hp) were overexpressed above 1.5-fold in all DM subgroups. Cp in T1DM and Hp in both types of DM were more expressed in HbA 1c ≥ 53 mmol/mol than <53 mmol/mol. Apolipoprotein A-I (Apo A-I) was upregulated only in T2DM subgroups. Conclusion In summary, three positive acute-phase proteins, AMG, Cp and Hp were more abundant in diabetic individuals regardless of the diabetes type. The highest Hp abundance in both types of DM with HbA 1c ≥ 53 mmol/mol, reinforces Hp as a possible biomarker associated with diabetic complications.

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“…36 A recent study done in Hispanics shows that subjects with the Hp2 allele may have a higher risk for the occurrence of T2DM. 37 As such, the current data show conflicting results and the association of the Hp genotypes with diabetes mellitus remains undetermined. In one Japanese cross-sectional analysis of >300 patients, an association was seen for fatty liver disease and non-alcoholic fatty liver disease in Hp2 carriers and this was associated with ferritin concentrations.…”

Section: Introductionmentioning

confidence: 84%

The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus

Dalan

Ling

2018

Eur J Prev Cardiolog

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Introduction and background Haptoglobin (Hp) is considered to be an antioxidant and protective against cardiovascular complications. Polymorphisms in the Hp gene interact with diabetes mellitus to affect the risk of vascular complications. Methods We review the updated literature about the protean role of Hp and Hp genotypes spanning genomics, molecular, translational and clinical studies. We searched Pubmed, SCOPUS and Google Scholar for all articles using the keywords: haptoglobin and/or haptoglobin polymorphism and diabetes. We review the diverse Hp genotypes, phenotypes and the impact on diabetes complications, including lessons from animal models and in vitro models. We describe the clinical studies on the associations of Hp genotypes with vascular complications in type 1 and type 2 diabetes comprehensively. We review the studies looking at vitamin E supplementation in a personalized manner in Hp2-2 diabetes individuals. Results and conclusion Hp genotypes have evolved as a result of deletions in the traditional Hp genes. The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. A preferential benefit of vitamin E and other antioxidants in the Hp2-2 genotype for cardiovascular complications in type 2 diabetes has been seen presumably secondary to interaction with high-density lipoprotein function. Hence, the Hp genotype can be used to personalize antioxidant therapeutics in diabetes patients. These results need to be corroborated in large, global, pragmatic, prospective, cardiovascular outcome trials in type 2 diabetes patients.

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Differentially expressed haptoglobin as a potential biomarker for type 2 diabetic mellitus in Hispanic population

Cited by 6 publications

References 52 publications

Hp1-1 as a Genetic Marker Regulating Inflammation and the Possibility of Developing Diabetic Complications in Patients with Type 2 Diabetes—Cohort Studies

Hp1-1 as a Genetic Marker Regulating Inflammation and the Possibility of Developing Diabetic Complications in Patients with Type 2 Diabetes—Cohort Studies

Prospection of plasma proteins as biomarkers for diabetes mellitus monitoring

The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus

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