Differentially Expressed Coding and Noncoding RNAs in CoCl
            <sub>2</sub>
            -Induced Cytotoxicity of C2C12 Cells

Chen, Rui; She, Yanling; Fu, Qiang; Chen, Xiaodan; Shi, Huacai; Liu, Si; Zhou, Shanyao; Ou, Jun; Liu, Yulin

doi:10.2217/epi-2018-0087

Cited by 6 publications

(5 citation statements)

References 43 publications

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“…Except starvation and fasting, multiple physiological and pathological conditions, including immobilization, mechanical unloading, cancer and chronic disease, can also trigger muscle atrophy (3,4). Our previous studies demonstrated that decreases in actin fiber size resulted in reduced expression of myogenin, and elevated expression of atrogin-1 induced by cobalt dichloride mimicking hypoxia, which subsequently led to skeletal muscle atrophy (5,6).…”

Section: Introductionmentioning

confidence: 99%

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

et al. 2019

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Starvation or severe deprivation of nutrients, which is commonly seen in surgical patients, can result in catabolic changes in skeletal muscles, such as muscle atrophy. Therefore, it is important to elucidate the underlying molecular regulatory mechanisms during skeletal muscle atrophy. In the present study, muscular atrophy was induced by starvation and the results demonstrated that myosin heavy chain was decreased, whereas muscle RING finger protein 1 and atrogin-1 were increased, both in vitro and in vivo. The impact of starvation on the expression patterns of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) was next determined. The expression patterns of miR-23a, miR-206 and miR-27b in the starved mice exhibited similar trends as those in starved C2C12 cells in vitro, whereas the expression patterns of six other miRNAs (miR-18a, miR-133a, miR-133b, miR-186, miR-1a and miR-29b) differed between the in vivo and the in vitro starvation models. The present study indicated that in vitro expression of the selected miRNAs was not completely consistent with that in vivo. By contrast, lncRNAs showed excellent consistency in their expression patterns in both the in vitro and in vivo starvation models; six of the lncRNAs (Atrolnc-1, long intergenic non-protein coding RNA of muscle differentiation 1, Myolinc, lncRNA myogenic differentiation 1, Dum and muscle anabolic regulator 1) were significantly elevated in starved tissues and cells, while lnc-mg was significantly decreased, compared with the control groups. Thus, lncRNAs involved in muscle atrophy have the potential to be developed as diagnostic tools.

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Section: Introductionmentioning

confidence: 99%

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

et al. 2019

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“…102 circFGFR4 binding to miR-107 promotes cell differentiation by targeting Wnt3a in bovine primary myoblasts. 95 Our research group has identified the coding potentials and known functional domains of 75 circRNAs during mouse C2C12 myoblast differentiation, 30 as well as 71 circRNAs with coding potential and known functional domains during pathological conditions of Co (II) ion-induced myocytotoxicity in mouse skeletal 108 In the future, other circRNAs encoding proteins involved in muscle development may be discovered. 104 Moreover, circSNX29 sponges miR-744 to facilitate bovine myoblasts differentiation and inhibit cell proliferation by activating the Wnt5a/Ca 2+ signalling pathway.…”

Section: Muscle Developmentmentioning

confidence: 99%

“…107 In addition to promoting proliferation, circ-ZNF609 is translated into a protein, but the function of the flagged protein is unknown in human myoblasts. 95 Our research group has identified the coding potentials and known functional domains of 75 circRNAs during mouse C2C12 myoblast differentiation, 30 as well as 71 circRNAs with coding potential and known functional domains during pathological conditions of Co (II) ion-induced myocytotoxicity in mouse skeletal 108 In the future, other circRNAs encoding proteins involved in muscle development may be discovered.…”

Section: Muscle Developmentmentioning

confidence: 99%

Roles of lncRNAs and circRNAs in regulating skeletal muscle development

et al. 2019

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The multistep biological process of myogenesis is regulated by a variety of myoblast regulators, such as myogenic differentiation antigen, myogenin, myogenic regulatory factor, myocyte enhancer factor2A-D and myosin heavy chain. Proliferation and differentiation during skeletal muscle myogenesis contribute to the physiological function of muscles. Certain non-coding RNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are involved in the regulation of muscle development, and the aberrant expressions of lncRNAs and circRNAs are associated with muscular diseases. In this review, we summarize the recent advances concerning the roles of lncRNAs and circRNAs in regulating the developmental aspects of myogenesis. These findings have remarkably broadened our understanding of the gene regulation mechanisms governing muscle proliferation and differentiation, which makes it more feasible to design novel preventive, diagnostic and therapeutic strategies for muscle disorders. K E Y W O R D ScircRNAs, development, differentiation, lncRNAs, proliferation, skeletal muscle

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“…A systematic review of our groups provided a summary of the known functions and mechanisms of lncRNAs in skeletal muscle development ( Chen et al, 2020 ). However, 4,409 lncRNAs are differentially regulated by CoCl 2 ( Chen et al, 2019 ), which triggers atrophy in skeletal C2C12 myotubes ( Chen et al, 2017 ), indicating the potential involvement of lncRNAs in muscle wasting.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs

Chen

Liu

Jiang

et al. 2020

Front. Cell Dev. Biol.

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Skeletal muscle atrophy is a common complication of cachexia, characterized by progressive bodyweight loss and decreased muscle strength, and it significantly increases the risks of morbidity and mortality in the population with atrophy. Numerous complications associated with decreased muscle function can activate catabolism, reduce anabolism, and impair muscle regeneration, leading to muscle wasting. microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), types of non-coding RNAs, are important for regulation of skeletal muscle development. Few studies have specifically identified the roles of miRNAs and lncRNAs in cellular or animal models of muscular atrophy during cachexia, and the pathogenesis of skeletal muscle wasting in cachexia is not entirely understood. To develop potential approaches to improve skeletal muscle mass, strength, and function, a more comprehensive understanding of the known key pathophysiological processes leading to muscular atrophy is needed. In this review, we summarize the known miRNAs, lncRNAs, and corresponding signaling pathways involved in regulating skeletal muscle atrophy in cachexia and other diseases. A comprehensive understanding of the functions and mechanisms of miRNAs and lncRNAs during skeletal muscle wasting in cachexia and other diseases will, therefore, promote therapeutic treatments for muscle atrophy.

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Differentially Expressed Coding and Noncoding RNAs in CoCl ₂ -Induced Cytotoxicity of C2C12 Cells

Cited by 6 publications

References 43 publications

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

Roles of lncRNAs and circRNAs in regulating skeletal muscle development

Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs

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Differentially Expressed Coding and Noncoding RNAs in CoCl 2 -Induced Cytotoxicity of C2C12 Cells

Cited by 6 publications

References 43 publications

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

Roles of lncRNAs and circRNAs in regulating skeletal muscle development

Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs

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Product

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Differentially Expressed Coding and Noncoding RNAs in CoCl ₂ -Induced Cytotoxicity of C2C12 Cells