Differential White Matter Regional Alterations in Motor Subtypes of Early Drug-Naive Parkinson’s Disease Patients

Wen, Ming‐Ching; Heng, Hannah S. E.; Lu, Zejun; Xu, Zheyu; Chan, Ling‐Ling; Tan, Eng King; Tan, Louis C.S.

doi:10.1177/1545968317753075

Cited by 42 publications

(67 citation statements)

References 55 publications

(77 reference statements)

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“…Zhang et al (2015) showed that patients with PD had higher global and local efficiency compared to HCs, which did not correlate with respective clinical scores. In addition, there was no difference between PD and HC subjects in the graph parameters in two other separate studies by Wen et al (2017, 2018). However, a recent study by Mishra et al (2019) found a significantly impaired global information network transfer in patients with PD indicated by lower normalized clustering coefficient, small worldness, and modularity.…”

Section: Resultsmentioning

confidence: 61%

“…Other association fibers with possible compensatory alterations included internal capsule (IC), external capsule (EC), fornix, forceps minor, and uncinate fasciculus (UF). Using TBSS, Wen et al (2018) showed that TD‐PD patients have lower RD in fornix compared to HCs. In agreement, fornix and also UF as WM fibers were introduced with higher connectivity in proPD, in comparison to PD subjects (Sanjari Moghaddam et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…As CC is the main WM tract connecting two hemispheres of the brain, increased structural connectivity of CC in the early stages of PD might improve information transfer and, thereby, counterbalancing the consequences of pathological changes in one hemisphere. Furthermore, association fibers such as cingulum, ILF, and IFOF, which connect the anterior and posterior cortical regions, had increased FA or decreased MD/RD in PD subjects and correlated with better olfaction and lower motor severity (Sanjari Moghaddam et al, 2019; Taylor et al, 2018; Wen et al, 2016, 2018). The increased connectivity in these WM structures might facilitate efficient information transfer between different regions of the brain and, thus, could act as a powerful compensatory mechanism.…”

Section: Discussionmentioning

confidence: 99%

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Structural white matter alterations as compensatory mechanisms in Parkinson's disease: A systematic review of diffusion tensor imaging studies

Moghaddam

Dolatshahi

Mohebi

et al. 2020

J of Neuroscience Research

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Compensation is described as normal or near to normal performance in Parkinson's disease (PD), despite the ongoing neural loss. Functional compensation typically proceeds in an inverse U-shaped manner: compensation initiates in the prodromal phase, followed by an increasing episode until plateauing and diminishes in the advanced stages of the disease. The first evidence of the structural compensation was reported by functional magnetic resonance imaging studies. Recent studies, which have used diffusion tensor imaging (DTI) as the basis for their investigation, have shown improved white matter diffusional properties both in motor-and non-motorrelated structures in association with improved clinical scores in patients with PD.The majority of DTI studies have demonstrated microstructural compensation in the prodromal/early stages of PD at the regional scale. However, there have been reports of compensation in later stages of the disease and the whole-brain/network scale that are probably due to the heterogeneous nature of PD. Although serving as a promising beginning to characterize compensation, lots remain to be clarified in understanding the underlying mechanisms of compensation and its structural pattern in PD. The existing knowledge gap necessitates studies that their main research questions are focused on structural compensation. This requirement becomes more apparent because structural compensation evidence has mostly emerged from the post hoc analysis of data and incidental findings of studies. Thus, future studies are required to investigate compensatory microstructural changes in PD to clarify the exact underlying mechanisms. These studies would also provide a basis to develop clinical improvements in the early diagnosis and management of PD. K E Y W O R D S compensation, diffusion tensor imaging, FA, MD, Parkinson's disease, white matter | 1399 SANJARI MOGHADDAM et Al.

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Section: Resultsmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Structural white matter alterations as compensatory mechanisms in Parkinson's disease: A systematic review of diffusion tensor imaging studies

Moghaddam

Dolatshahi

Mohebi

et al. 2020

J of Neuroscience Research

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“…Previous studies have attempted to delineate different WM changes in PD motor subtypes. Changes in mean diffusivity and axial diffusivity in the cerebral peduncles, thalamus, internal capsule, superior corona radiata, and increases in FA in the left anterior thalamic radiation, left IFOF, left/right SLF, left/right ILF, and right corticospinal tract, were specifically seen in tremor‐dominant PD subjects.…”

Section: Discussionmentioning

confidence: 91%

White matter myelin profiles linked to clinical subtypes of Parkinson's disease

Baumeister

Kim

Zhu

et al. 2018

Magnetic Resonance Imaging

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Background White matter (WM) microstructural integrity is important for effective brain functioning and alterations have been shown in many neurodegenerative diseases. Purpose To investigate WM myelin profiles and their relation to clinical features of Parkinson's disease (PD). Study Type Retrospective cross‐sectional. Population In all, 29 PD subjects and 15 healthy controls. Field Strength/Sequence Multiecho GRASE with 10 msec echo spacing and echo planar imaging (EPI) diffusion‐weighted (b‐value = 700 with 32 gradient directions) on a 3T scanner. Assessment Myelin water fraction (MWF) and fractional anisotropy (FA) across 20 WM regions of interest (ROIs) were compared between groups. Partial least squares (PLS) was used to associate MWF and FA with clinical and behavioral measures. Statistical Tests Group comparisons were done using two‐sample t‐tests. PLS was assessed with permutation tests. Bootstrapping was used to investigate the robustness of imaging features. Results No group differences in myelin content could be detected with univariate tests. A three‐component PLS model linked MWF profiles to clinical phenotypes but no FA profiles. The three components appeared to follow along broad motor/nonmotor subtypes of “akinetic‐rigid,” “tremor‐predominant,” and “depression/apathy” subtypes, respectively. The first component showed associations between overall motor scores (r = –0.43, P = 0.0196) and cognitive performance (r = 0.44, P = 0.0171) with interhemispheric and long‐range association fibers. A second component linked overall motor scores (r = –0.58, P = 0.0009) and tremor scores (r = –0.48, P = 0.0091) to predominantly projection fibers. The last component related depression (r = –0.60, P = 0.0006) and apathy scores (r = –0.66, P = 0.0001 and r = –49, P = 0.0072) to a mixture of association and projection fibers. Data Conclusion MWF was robustly linked to distinct clinical subtypes of PD and may serve as an additional tool to characterize the disease. Level of Evidence: 4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:164–174.

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“…The authors have discussed this finding as a neural compensation for nigrostriatal dopaminergic loss leading to more benign disease course in TD subtype. Additionally, White matter alterations were also more significantly related to severity of symptoms in PIGD than that of TD (Wen et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Association between peripheral inflammation and DATSCAN data of the striatal nuclei in different motor subtypes of Parkinson Disease

Moghaddam

Sherbaf

Zadeh

et al. 2018

Preprint

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Purpose: The etiopathology of Parkinson disease (PD) and several other neurodegenerative diseases is inseparable from inflammatory processes. Peripheral neuroinflammation has been postulated to be involved in the initiation and progression of PD.Method: DATSCAN was applied to assess the dopaminergic loss in the brain of 391 PD patients and 151 healthy controls. Once the blood sample was collected, neutrophil to lymphocyte ratio (NLR) was calculated by autoanalyzer device on participants' whole blood samples.Results: NLR was significantly correlated with caudal SBR in individuals with PD, even after adjustment for age and disease duration. NLR could not predict putaminal SBR in PD patients after adjusting for age or age and disease duration.Conclusion: based on our findings, it is believed that peripheral inflammatory processes play a notable role in the pathogenesis of PD. NLR as an excellent representative for peripheral neuroinflammation could be considered a potential candidate biomarker for PD.

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Differential White Matter Regional Alterations in Motor Subtypes of Early Drug-Naive Parkinson’s Disease Patients

Cited by 42 publications

References 55 publications

Structural white matter alterations as compensatory mechanisms in Parkinson's disease: A systematic review of diffusion tensor imaging studies

Structural white matter alterations as compensatory mechanisms in Parkinson's disease: A systematic review of diffusion tensor imaging studies

White matter myelin profiles linked to clinical subtypes of Parkinson's disease

Association between peripheral inflammation and DATSCAN data of the striatal nuclei in different motor subtypes of Parkinson Disease

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