Differential Treatment Effects of Subgroup Analyses in Phase 3 Oncology Trials From 2004 to 2020
Alexander D. Sherry,
Andrew W. Hahn,
Zachary R. McCaw
et al.
Abstract:ImportanceSubgroup analyses are often performed in oncology to investigate differential treatment effects and may even constitute the basis for regulatory approvals. Current understanding of the features, results, and quality of subgroup analyses is limited.ObjectiveTo evaluate forest plot interpretability and credibility of differential treatment effect claims among oncology trials.Design, Setting, and ParticipantsThis cross-sectional study included randomized phase 3 clinical oncology trials published prior … Show more
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