Differential Transmission of Down's Syndrome (Mongolism) Through Male and Female Translocation Carriers

Hamerton, J.L.; Cowie, ValerieA.; Giannelli, F.; Briggs, SusanM.; Polani, P. E.

doi:10.1016/s0140-6736(61)90795-4

Cited by 64 publications

(8 citation statements)

References 12 publications

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“…(1965), where a satellite-like form was observed on the long arm of the abnormal chromosome. Hamerton et al (1961), Hamerton and Steinberg (1962), Lejeune (1964), Stalder et al (1965), Hecht (1965Hecht ( ), H amerton (1966 and Mikkelsen (1966) have shown that the offspring of a male translocation-21 carrier are more often euploid than those of a female carrier, for whom the probability of aneuploid offspring is greater. The ratio between euploid and aneuploid offspring is different from that expected if random segregation were involved.…”

Section: Discussionmentioning

confidence: 99%

Pericentric inversion in a family with a 21/22 translocation

Soudek¹,

Laxová²,

Adamek³

1968

Cytogenet Genome Res

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Section: Discussionmentioning

confidence: 99%

Pericentric inversion in a family with a 21/22 translocation

Soudek¹,

Laxová²,

Adamek³

1968

Cytogenet Genome Res

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“…In either case there was equivalence with the number of spontaneously aborted progeny in the first trimester. Initial evidence that segregation ratios in the offspring of male and female translocation carriers may be quite different was shown by Hamerton et al (1961). Equations applicable to the segregation ratios in t(D ;21) have been developed by Stene (1970a, b), and Stene (1970c) has calculated the risk rate for mongolism for female carriers as 0.10085 ± 0.01825.…”

Section: Segregationmentioning

confidence: 99%

Structure and inheritance of some heterozygous Robertsonian translocation in man.

Daniel¹,

Lam‐Po‐Tang²

1976

Journal of Medical Genetics

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Summary. Banding studies in 25 Robertsonian translocations showed that all could be interpreted as stable dicentrics. The mechanism for their stability is likely to be the proximity of their centromeres but centromeric suppression could also have a role. In many of these dicentric translocations, discontinuous centromeric suppression, as indicated by chromatid separation at one of the centromeric regions, was observed in C-banded preparations. A further observation of undefined relation to

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“…(See Sasaki, 1965;Hamerton et al, 1961;Kjessler, 1964. Careful analysis of pairs of second meiotic metaphase figures should yield an answer.…”

Section: Precocious Disjunctioumentioning

confidence: 99%