Differential time courses of c-fos mRNA expression in hippocampal subfields following acquisition and recall testing in mice

Bertaina, Valérie; Destrade, Claude

doi:10.1016/0926-6410(95)90018-7

Cited by 43 publications

(29 citation statements)

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“…The expression of this gene is rapidly and transiently induced in the central nervous system by a variety of stimuli (for recent review, see Hughes and Dragunow 1995). Moreover, numerous reports have shown increased c-fos expression after learning experiments in chicken and rodents Campeau et al 1991;Bialy et al 1992;Brennan et al 1992;Irwin et al 1992;Nikolaev et al 1992a,b;Ambalavanar et al 1993;Heurteaux et al 1993;McCabe and Horn 1993;Pezzone et al 1993;Houpt et al 1994;Bertaina and Destrade 1995;Hess et al 1995). Thus, it has been suggested that c-Fos is involved in processes of long-term memory formation, by coupling transient extracellular stimuli to long-lasting cellular responses at the level of transcription (Goelet et al 1986;Morgan and Curran 1989).…”

Section: Introductionmentioning

confidence: 99%

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Grimm¹,

Schicknick²,

Riede³

et al. 1997

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IntroductionRecently, the induction of transcription factor-encoding immediate-early genes such as c-fos was observed in distinct brain regions of rats trained to acquire a footshock-motivated brightness discrimination in a Y-maze. The functional relevance of inducible transcription factors for learning and memory formation is, however, not clear. To address this question in the present study, we have used a synthetic antisense phosphorothioate oligodeoxynucleotide to suppress in vivo the expression of c-fos in rat brain.

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Section: Introductionmentioning

confidence: 99%

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Grimm¹,

Schicknick²,

Riede³

et al. 1997

Learn. Mem.

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“…Lesion studies in rats tend to confirm a lack of hippocampal involvement in social recognition memory (Bannerman et al, 2001(Bannerman et al, , 2002Squires et al, 2006). In contrast, c-Fos activation is clearly increased in the hippocampus of mice and rats after tasks that rely on spatial navigation (Bertaina and Destrade, 1995;Vann et al, 2000;Guzowski et al, 2001;Shires and Aggleton, 2008). Therefore, the underlying mechanisms of social recognition memory and spatial memory are likely different.…”

Section: Mapping the Brain Regions Involved In Social Recognitionmentioning

confidence: 98%

Social memories in rodents: Methods, mechanisms and modulation by stress

Kooij

Sandi

2012

Neuroscience & Biobehavioral Reviews

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a b s t r a c tIntact social memory forms the basis of meaningful interactions between individuals. Many factors can modulate the quality of social memory, and these have been studied in detail in rodents. Social memory, however, cannot be considered a single entity. The term social memory reflects different processes, such as social recognition of a novel conspecific individual and social learning (or 'learning from others'). This review summarizes the findings obtained with behavioral paradigms that were developed for the study of memory formation by social recognition and social learning. In particular, we focus on studies that include tests for social habituation/discrimination paradigms, tests for memory of a previously established social hierarchy and the social transmission of the food preference test. The role of individual differences and the main neurobiological mechanisms (i.e., the brain regions and neurochemical systems involved) that have been implicated in each of these types of social-related memories are reviewed. In addition, we address the key modulatory influence of stress on the formation of these types of memories; discussing the contribution of central (corticotropin-releasing factor, CRF) and peripheral (glucocorticoids) stress systems and their interactions with the social neuropeptide systems. Overall, we present here a general overview of the current state of a thriving research area within the field of social neuroscience.

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“…As CA3 pyramidal cells have numerous recurrent collaterals, this area is considered in some computational models as an auto-associative network for storage and retrieval of information in memory processes (Treves and Rolls 1992). Bertaina and Destrade (1995), using in situ hybridization of c-fos mRNA and an appetitive conditioning paradigm, further reported an involvement of the CA3 after memory retrieval.…”

Section: Learning and Memory 313mentioning

confidence: 99%

“…Those authors assumed that it might be due to the reactivation which was not of sufficient amplitude or duration, since the rats received only a single reinforced retrieval trial. On the other hand, in a c-fos mapping study, Bertaina and Destrade (1995) assessed memory retrieval of an appetitive conditioning by submitting mice to five reinforced trials, and they observed modifications in Fos expression. In conditioning procedures based on getting a reward, it seems that the retrieval session should consist of several trials.…”

Section: Learning and Memory 311mentioning

confidence: 99%

“…Beside its involvement in olfactory information processing, the role of the hippocampus in consolidation and reactivation of memory has been studied extensively (Eichenbaum 2001;Debiec et al 2002), and this area could have a time-limited role in memory storage (Bontempi et al 1999). Lastly, a differential spatiotemporal pattern of c-fos mRNA expression was described in hippocampal subfields after either acquisition or recall of an appetitive conditioning task in mice (Bertaina and Destrade 1995). The PCx is also interconnected to the medial and orbital frontal cortices (Datiche and Cattarelli 1996).…”

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Fos protein expression in olfactory-related brain areas after learning and after reactivation of a slowly acquired olfactory discrimination task in the rat

Roullet¹

2005

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Fos protein immunodetection was used to investigate the neuronal activation elicited in some olfactory-related areas after either learning of an olfactory discrimination task or its reactivation 10 d later. Trained rats (T) progressively acquired the association between one odor of a pair and water-reward in a four-arm maze. Two groups of pseudotrained rats were used: PO rats were not water restricted and were submitted to the olfactory stimuli in the maze without any reinforcement, whereas PW rats were water-deprived and systematically received water in the maze without any odorous stimulation. When the discrimination task was well mastered, a significantly lower Fos immunoreactivity was observed in T rats compared to PW and PO rats in most of the analyzed brain areas, which could reflect the post-acquisition consolidation process. Following memory reactivation, differences in Fos immunoreactivity between trained and some pseudotrained rats were found in the anterior part of piriform cortex, CA3, and orbitofrontal cortex. We also observed that Fos labeling was significantly higher in trained rats after memory reactivation than after acquisition of the olfactory task in most of the brain areas examined. Our results support the assumption of a differential involvement of neuronal networks after either learning or reactivation of an olfactory discrimination task.

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Differential time courses of c-fos mRNA expression in hippocampal subfields following acquisition and recall testing in mice

Cited by 43 publications

References 30 publications

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Suppression of c-fos induction in rat brain impairs retention of a brightness discrimination reaction.

Social memories in rodents: Methods, mechanisms and modulation by stress

Fos protein expression in olfactory-related brain areas after learning and after reactivation of a slowly acquired olfactory discrimination task in the rat

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