Differential synovial Th1 cell reactivity towards<i>Escherichia coli</i>antigens in patients with ankylosing spondylitis and rheumatoid arthritis

Syrbe, Uta; Scheer, Rebecca; Wu, Peng; Sieper, Joachim

doi:10.1136/annrheumdis-2012-201404

Cited by 21 publications

(7 citation statements)

References 16 publications

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“…Similarly, P. gingivalis was shown to be the potential initiator, causing RA to form ACPAs [84]. Recent studies have shown a close relationship between microbiota and RA, including Mycoplasma [86] , Proteus [87], Escherichia [88], Haemophilusspp, Lactobacillussalivarius , etc. [89].…”

Section: Effects Of Gut Microbiome and Mucosal Immunity In Autoimmunementioning

confidence: 99%

Interaction between the gut microbiome and mucosal immune system

Shi¹,

et al. 2017

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The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.

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Section: Effects Of Gut Microbiome and Mucosal Immunity In Autoimmunementioning

confidence: 99%

Interaction between the gut microbiome and mucosal immune system

Shi¹,

et al. 2017

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“…found that the E. coli-specific Th1 response was significantly reduced in Crohn’s patients and to a lower extent also in AS patients ( 32 ), and Syrbe et al. found that the high frequency and enrichment of E coli-specific CD4 T cells in the inflamed joints of patients with AS ( 33 ), which suggested that the “Pathogenic Escherichia coli infection” might be relevant to AS. For the “Pathogenic Escherichia coli infection” pathway, the study recognized some important inflammatory factors, such as TNF-α, IL‐1β, IL‐1, IL‐8, and NF‐κb, which were associated with different signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Peptidomics analysis of plasma in patients with ankylosing spondylitis

Guo-ning

Xu²,

Jin³

2023

Front. Immunol.

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BackgroundThis study aimed to explore the differential expression of peptides associated with ankylosing spondylitis (AS) patients, enabling identification of potential functional peptides to provide the basis for the novel intervention targets for AS.Material and Methods3 AS patients and 3 healthy volunteers were enrolled in this study. The expression profiles for peptides present in the plasma of AS patients and the healthy individual were analyzed by liquid chromatography-tandem mass spectrometry (LC‐MS/MS). The physicochemical properties and biological functions of identified peptides were further analyzed by bioinformatics. The results of peptide identification were verified by cell viability analysis, using CCK8 and Edu staining assay, and the differential peptides relevant to the disease were screened.Results52 differential peptides were successfully identified using mass spectrometry. 44 peptides were up-regulated, while eight were down-regulated. FGA-peptide (sequences: DSGEGDFLAEGGGVRGPR), C4A-peptide (sequences: NGFKSHAL), and TUBB-peptide (sequences: ISEQFTAMFR) were screened out that could significantly promote the proliferation of fibroblasts in AS patients. Bioinformatics analysis showed these differentially expressed peptides might be associated with “MHC class I protein binding” and “pathogenic Escherichia coli infection” pathways, which might further affect the progression of AS.ConclusionThis pilot study shows 3 differentially expressed peptides may have the potential function for the occurrence and development of AS, may provide novel insights into the underlying molecular mechanisms of AS based on peptide omics.

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“… 20 Environmental factors such as Escherichia coli have also been proven to aggravate autoimmunity in AS and NMOSD (however, body fluid cultures for Escherichia coli , performed in our patient, showed similar association, and they were found negative two times). 21 , 22 Although large-scale epidemiological studies investigating the underlying pathogenesis related to these diseases are lacking, studies have demonstrated an increased incidence of optic neuritis among patients with AS. 23 Systemic sclerosis and mixed and undifferentiated connective tissue diseases were excluded after expert opinions (from two board-certified rheumatologists and two dermatologists) because of the lack of suggestive clinical findings (e.g., absence of skin thickening, salt-and-pepper appearance, nail changes, Mauskopf facies, sclerodactyly, calcinosis cutis, Raynaud’s phenomenon, other cutaneous manifestations, pulmonary arterial hypertension/interstitial lung disease, dysphagia, muscular pain/weakness renal impairments, absence of ANA, anti-centromere antibodies, anti-Scl-70, PM-Scl antibodies, anti-ds DNA, PCNA, CENP-B, anti-nucleosomes, anti-Smith, anti-U1-RNP, anti-Jo1, anti-Mi2, anti-Ro52, anti-La antibodies, and normal C3 and C4 complement levels) (The European League Against Rheumatism and the American College of Rheumatology classification criteria 2019).…”

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confidence: 99%

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confidence: 99%

Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum

Ghosh

Roy

León-Ruiz

et al. 2022

Qatar Medical Journal

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Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels. Patients with NMOSD tend to have other coexisting autoimmune/connective tissue diseases. However, AQP-4-antibody-positive NMOSD coexisting with ankylosing spondylitis (AS) is rare. AS is an immune-mediated disorder, a subset of axial spondyloarthropathies, which commonly manifests as chronic inflammatory back pain in young people, and it has a strong association with HLA-B27. In this study, a 35-year-old Indian man with an undiagnosed progressive axial spondyloarthropathy (i.e., AS) is reported presenting with acute-onset longitudinally extensive transverse myelitis, a clinical subset of NMOSD. Neuromyelitis optica spectrum disorder (NMOSD), a primary demyelinating disorder of the central nervous system (CNS), is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels, which manifests with optic neuritis, longitudinally extensive transverse myelitis (LETM), area-postrema syndrome, brainstem syndrome diencephalic syndrome, and cerebral syndrome. 1 – 4 Ankylosing spondylitis (AS) is an immune-mediated disorder, a subset of axial spondyloarthropathies, which commonly manifests as chronic inflammatory back pain in young people, and it has a strong association with HLA-B27. 5 , 6 AS characteristically targets the axial skeleton, peripheral joints, entheses (connective tissues between tendons/ligaments and bones), and gut. 5 , 6 Patients with NMOSD tend to have other coexisting autoimmune/connective tissue diseases. 7 For example, cases with NMOSD and multiple sclerosis, which are other autoimmune primary demyelinating disorders of the CNS, have been reported. 8 , 9 However, concurrent existence of AS and NMOSD in the same patient even over years of disease course is rare. 10 , 11 In addition, studies describing neurological manifestations of AS are limited, 12 and they focus on joint inflammation and long-standing bony pathology (ankylosis) related to compressive myelopathy, myelo-radiculopathy, and cauda equina syndromes. 12 , 13 The authors present a case of a young Indian man with an undiagnosed progressive AS (misdiagnosed and mismanaged by an indigenous medical practitioner) presenting with acute-onset LETM variant of AQP4-positive NMOSD. A 35-year-old healthy, non-comorbid man from rural India came to the outpatient department with complaints of persistent tingling, numbness, and weakness of both lower limbs (right more than left) for 10 days. The clinical picture showed acute-onset urinary retention, which was relieved by urinary cathete...

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Differential synovial Th1 cell reactivity towardsEscherichia coliantigens in patients with ankylosing spondylitis and rheumatoid arthritis

Abstract: The high frequency and enrichment of E coli-specific CD4 T cells in the inflamed joints of patients with AS but not those with RA suggests that commensal bacteria are relevant antigens in AS that might trigger the disease.

Cited by 21 publications

References 16 publications

Interaction between the gut microbiome and mucosal immune system

Interaction between the gut microbiome and mucosal immune system

Peptidomics analysis of plasma in patients with ankylosing spondylitis

Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum

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