Differential sympathetic activation in muscle and skin neural districts in the metabolic syndrome

Quartı-Trevano, Fosca; Seravalle, Gino; Dubini, A.; Mancia, Giuseppe

doi:10.1016/j.metabol.2009.04.028

Cited by 19 publications

(15 citation statements)

References 26 publications

(57 reference statements)

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“…Our findings were in line with most other cross-sectional studies investigating the association between metabolic abnormalities and ANS functioning (3,13,14). Elevated sympathetic nervous system activity and diminished parasympathetic nervous system activity were found in subjects with metabolic syndrome (15)(16)(17)(18)(19). As far as we know, only one longitudinal study has been performed that investigated the predictive value of metabolic syndrome factors for changes in HR variability (20).…”

supporting

confidence: 91%

Dysregulation of the Autonomic Nervous System Predicts the Development of the Metabolic Syndrome

Licht

Geus

Penninx

2013

The Journal of Clinical Endocrinology &Amp; Metabolism

119

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Context:Stress is suggested to lead to metabolic dysregulations as clustered in the metabolic syndrome. Although dysregulation of the autonomic nervous system is found to associate with the metabolic syndrome and its dysregulations, no longitudinal study has been performed to date to examine the predictive value of this stress system in the development of the metabolic syndrome.Objective: We examined whether autonomic nervous system functioning predicts 2-year development of metabolic abnormalities that constitute the metabolic syndrome.Design: Data of the baseline and 2-year follow-up assessment of a prospective cohort: the Netherlands Study of Depression and Anxiety was used.Setting: Participants were recruited in the general community, primary care, and specialized mental health care organizations.Participants: A group of 1933 participants aged 18 -65 years. Main outcome measures:The autonomic nervous system measures included heart rate (HR), respiratory sinus arrhythmia (RSA; high RSA reflecting high parasympathetic activity), pre-ejection period (PEP; high PEP reflecting low sympathetic activity), cardiac autonomic balance (CAB), and cardiac autonomic regulation (CAR). Metabolic syndrome was based on the updated Adult Treatment Panel III criteria and included high waist circumference, serum triglycerides, blood pressure, serum glucose, and low high-density lipoprotein (HDL) cholesterol.Results: Baseline short PEP, low CAB, high HR, and CAR were predictors of an increase in the number of components of the metabolic syndrome during follow-up. High HR and low CAB were predictors of a 2-year decrease in HDL cholesterol, and 2-year increase in diastolic and systolic blood pressure. Short PEP and high CAR also predicted a 2-year increase in systolic blood pressure, and short PEP additionally predicted 2-year increase in diastolic blood pressure. Finally, a low baseline RSA was predictive for subsequent decreases in HDL cholesterol. Conclusion:Increased sympathetic activity predicts an increase in metabolic abnormalities over time. These findings suggest that a dysregulation of the autonomic nervous system is an important predictor of cardiovascular diseases and diabetes through dysregulating lipid metabolism and blood pressure over time.

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supporting

confidence: 91%

Dysregulation of the Autonomic Nervous System Predicts the Development of the Metabolic Syndrome

Licht

Geus

Penninx

2013

The Journal of Clinical Endocrinology &Amp; Metabolism

119

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“…Multiunit recordings revealed increased muscle sympathetic nerve activity in obese individuals and in patients with metabolic syndrome compared with control subjects. In contrast, skin sympathetic nerve activity did not differ among the groups (12). Plasma norepinephrine levels were associated with muscle sympathetic nerve activity but not with skin sympathetic nerve activity.…”

mentioning

confidence: 56%

“…Plasma norepinephrine levels were associated with muscle sympathetic nerve activity but not with skin sympathetic nerve activity. These data suggested that sympathetic overactivity observed in patients with metabolic syndrome is not distributed uniformly, and these authors speculate that insulin-induced sympathetic activation could be one of the mechanisms behind the differential regulation of sympathetic outflow (12). Furthermore, hypoglycemia leads to increase in sympathetic outflow to the liver and adrenal glands, whereas renal and cardiac sympa-thetic outflow are unaffected (4,7,33,34).…”

mentioning

confidence: 97%

“…Single-unit muscle sympathetic nerve activity was significantly greater in subjects with metabolic syndrome with or without hypertension compared with control subjects, whereas the multiunit discharges showed a similar trend (14). Another study investigated whether during metabolic syndrome the sympathetic activation is generalized to the whole cardiovascular system or is compartmentalized by comparing muscle and skin sympathetic nerve activity (12). Multiunit recordings revealed increased muscle sympathetic nerve activity in obese individuals and in patients with metabolic syndrome compared with control subjects.…”

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confidence: 99%

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Brain-liver connections: role of the preautonomic PVN neurons

O’Hare

Zsombok

2016

American Journal of Physiology-Endocrinology and Metabolism

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O'Hare JD, Zsombok A. Brain-liver connections: role of the preautonomic PVN neurons. Am J Physiol Endocrinol Metab 310: E183-E189, 2016. First published December 8, 2015; doi:10.1152/ajpendo.00302.2015.-Diabetes mellitus and the coexisting conditions and complications, including hypo-and hyperglycemic events, obesity, high cholesterol levels, and many more, are devastating problems. Undoubtedly, there is a huge demand for treatment and prevention of these conditions that justifies the search for new approaches and concepts for better management of whole body metabolism. Emerging evidence demonstrates that the autonomic nervous system is largely involved in the regulation of glucose homeostasis; however, the underlying mechanisms are still under investigation. Within the hypothalamus, the paraventricular nucleus (PVN) is in a unique position to integrate neural and hormonal signals to command both the autonomic and neuroendocrine outflow. This minireview will provide a brief overview on the role of preautonomic PVN neurons and the importance of the PVN-liver pathway in the regulation of glucose homeostasis. paraventricular nucleus; liver-related neurons; glucose homeostasis DIABETES MELLITUS is the most common metabolic disorder. The National Diabetes Statistics Report from 2014 published by the Centers for Disease Control and Prevention (8a) estimated that 29.1 million people, which is 9.3% of the US population, suffer from diabetes mellitus. Even more alarming information is that the number of new diabetes cases showed an increase of 1.7 million within 2 yr, and in 2010 diabetes mellitus was listed as the seventh leading cause of death. The coexisting conditions and complications of diabetes mellitus are severe, including hypo-and hyperglycemic events, high blood pressure, obesity, high cholesterol levels, and many more. Undoubtedly, there is a huge demand for treatment and prevention of these conditions that justifies the search for new approaches and solutions for better management of whole body metabolism. One possibility, which has recently attracted more interest, is the role of the brain in the regulation of metabolism (46, 50), particularly the contribution of the autonomic nervous system (ANS) to metabolic control (51,69,73,75).The hypothalamus has been known as one of the critical brain structures that is involved in the regulation and coordination of homeostatic functions. Traditionally, the hypothalamus was appreciated for its neuroendocrine control system; however, its control over the ANS has also been recognized (17,46,51,69,75

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“…Une telle altération avec augmentation de l'activité sympathique a aussi été rapportée chez les sujets ayant une intolérance au glucose [6] ou un syndrome métabolique [7][8][9].…”

Section: Introductionunclassified

Relation entre pression artérielle, fréquence cardiaque et dysfonction autonome cardiaque chez les obèses non diabétiques

Banu

Nguyen

Hamo-Tchatchouang

et al. 2015

Annales de Cardiologie et d'Angéiologie

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Differential sympathetic activation in muscle and skin neural districts in the metabolic syndrome

Cited by 19 publications

References 26 publications

Dysregulation of the Autonomic Nervous System Predicts the Development of the Metabolic Syndrome

Dysregulation of the Autonomic Nervous System Predicts the Development of the Metabolic Syndrome

Brain-liver connections: role of the preautonomic PVN neurons

Relation entre pression artérielle, fréquence cardiaque et dysfonction autonome cardiaque chez les obèses non diabétiques

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