Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling
Steven A Cincotta,
Nainoa Richardson,
Mariko H Foecke
et al.
Abstract:While physiologic stress has long been known to impair mammalian reproductive capacity through hormonal dysregulation, mounting evidence now suggests that stress experienced prior to or during gestation may also negatively impact the health of future offspring. Rodent models of gestational physiologic stress can induce neurologic and behavioral phenotypes that persist for up to three generations, suggesting that stress signals can induce lasting epigenetic changes in the germline. Treatment with glucocorticoid… Show more
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