Differential susceptibilities of spinal cord neurons to retinoic acid-induced survival and differentiation

Wuarin, L.; Sidell, Neil

doi:10.1016/0012-1606(91)90435-6

Cited by 65 publications

(35 citation statements)

References 20 publications

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“…The data presented here shows that the retinoid signalling pathway is critical for the survival of neurons of the adult CNS. This has been previously shown for the embryonic CNS, where in addition it is required for the differentiation of neurons (Wuarin and Sidell, 1991;Quinn and De Boni, 1991). Therefore, the role of the retinoid signalling pathway in neuron survival in the embryonic CNS is conserved in the adult CNS.…”

Section: Discussionsupporting

confidence: 59%

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Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients

Corcoran

Maden

2002

Journal of Cell Science

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We generated retinoid-deficient adult rats by the removal of retinoids from their diet. We show that their motoneurons undergo neurodegeneration and that there is an accumulation of neurofilaments and an increase in astrocytosis,which is associated with motoneuron disease. These effects are mediated through the retinoic acid receptor α. The same receptor deficit is found in motoneurons from patients suffering from spontaneous amyotrophic lateral sclerosis. Furthermore, we show that there is a loss of expression of the retinaldehyde dehydrogenase enzyme II in motoneurons. Therefore, we propose that a defect in the retinoid signalling pathway is in part be responsible for some types of motoneuron disease.

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Section: Discussionsupporting

confidence: 59%

“…RA is important for the birth, survival and function of neurons (Wuarin and Sidell, 1991;Quinn and De Boni, 1991). RA can stimulate both neurite number and length (Maden, 1998;Corcoran and Maden, 1999;Corcoran et al, 2000).…”

mentioning

confidence: 99%

Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients

Corcoran

Maden

2002

Journal of Cell Science

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“…If this is the case, one would expect every cervical and lumbar cell to be RA-activated. Alternately, RA signaling might contribute to establishing neuronal and glial diversity in these regions (Landmesser, 1978;Hunt, 1983;Honig et al, 1986;Oppenheim et al, 1989;Cabot, 1990;Wuarin and Sidell, 1991). If this is the case, one might expect to see only a subset of cells that respond to RA and express different RARs, RXRs, or binding proteins.…”

Section: Introductionmentioning

confidence: 99%

Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord

Colbert

Rubin

Linney

et al. 1995

Developmental Dynamics

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“…Probing into neurobiology and underlying signaling pathways regarding neural regeneration, stem cell proliferation and cell differentiation is one of the most promising area of research (Wuarin and Sidell, 1991;Wuarin et al, 1990;Zhelyaznik et al, 2003). However, complete molecular cross talking mechanisms remain ambiguous.…”

Section: Studies Carried Out By Mccollum and Davis In Early 19mentioning

confidence: 99%

Molecular mechanisms of reversing neural degeneration by retinoic acid, a major derivative of vitamin A

Ranaweera

Rajapakse

2017

Ceylon J. Sci.

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For the past hundred years since the discovery of vitamin A, the field of research associated with retinoids has been well evolved due to advances in molecular biology, chemistry, biochemistry and medicine. Vitamin A is an essential component in diet. Major derivatives of vitamin A such as retinol, retinaldehydes and retinoic acid are collectively considered as retinoids. Deficit of Vitamin A has a direct correlation with disease development in our body emphasizing the importance of retinol. Retinoic Acid is proclaimed as powerful mitogen acting in our body since the developmental embryonic stages where it is associated with many organ systems in body carrying out different functionalities. Retinoids carry out many functions of nervous systems. This review is mainly focused on contribution of Retinoic acid towards reversing the process of neural degeneration in pathological conditions achieved by neurodegenerative diseases and tumor inducing situations. Retinoids can act on neurons carrying morphogenesis of nerves by promoting stem cell differentiation. Activation of phospholipase A2 pathway can promote neural differentiation. Also by inactivating human Inhibitor of DNA binding 2 gene, retinols can suppress stem cell proliferation and initiate morphogenesis. This gene inactivation can be also used as a therapy to prevent malignant cell proliferation leading to tumors. Anti amyloidogenic activity is discussed in this review locates a significant importance in reversing neural degenerating process in diseased conditions. Moreover, Reactive Oxygen Species accumulation can be suppressed by Retinoic Acid where it can promote cell survival during pathological constrains. The revision of literature is carried out in depth revealing Retinoic Acid related putative drug target mechanisms, where we can use Retinoic Acid as a novel therapeutic drug in neurodegenerative diseases.

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Differential susceptibilities of spinal cord neurons to retinoic acid-induced survival and differentiation

Cited by 65 publications

References 20 publications

Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients

Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients

Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord

Molecular mechanisms of reversing neural degeneration by retinoic acid, a major derivative of vitamin A

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