Differential Susceptibilities of
 Anopheles albimanus
 and
 Anopheles pseudopunctipennis
 to Infections with Coindigenous
 Plasmodium vivax
 Variants VK210 and VK247 in Southern Mexico

González-Cerón, Lilia; Rodrı́guez, Mario H.; Nettel, Jose C.; Villarreal, Cuauhtémoc Calderón; Kain, Kevin C.; Hernandez, Juan E.

doi:10.1128/iai.67.1.410-412.1999

Cited by 76 publications

(35 citation statements)

References 23 publications

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“…This methodology allowed for the modeling of clustered data from different experiments, taking into consideration the correlation within each parasite sample (experiment), but used the pooled data in the model. Pooling data on different experiments (parasite samples) is a common statistical approach in the analysis of differential infection susceptibility (Gonzalez-Ceron et al, 1999;Rodriguez et al, 2000;Gonzalez-Ceron et al, 2007;Gonzalez-Ceron et al, 2010;Gonzalez-Ceron et al, 2019). Supplementary Table S2 shows the proportion of infected mosquitoes and the intensity of infection in each parasite sample.…”

Section: Discussionmentioning

confidence: 99%

“…Between 2001 and 2005, patients with at least 500 P. vivax parasites/µL of blood (7,000 white blood cells/µl was used as reference) were asked to donate five ml of venous blood. Infected blood samples were collected in heparin and centrifuged, and nonimmune human plasma was used to substitute the donor's plasma (Gonzalez-Ceron et al, 1999). To determine the infectivity of P. vivax in each blood sample, batches of female white-striped Ny.…”

Section: Plasmodium Vivax Parasites and Mosquito Infectionsmentioning

confidence: 99%

“…pseudopunctipennis (P/TAP-R) from insectary colonies held at CRISP were simultaneously offered infected blood in artificial feeders (Gonzalez-Ceron et al, 2019). Only engorged mosquitoes were maintained under insectary conditions (Gonzalez-Ceron et al, 1999). Seven days post blood feeding, the proportion of infected mosquitoes and oocyst numbers in the midgut were recorded.…”

Section: Plasmodium Vivax Parasites and Mosquito Infectionsmentioning

confidence: 99%

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Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

González-Cerón¹,

Rodrı́guez²,

Ovilla-Muñoz³

et al. 2020

Front. Genet.

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In the southern Pacific coast of Chiapas, Mexico (SM), the two most abundant vector species, Nyssorhynchus albimanus and Anopheles pseudopunctipennis, were susceptible to different Plasmodium vivax Pvs25/28 haplotypes. To broaden our understanding of the existing P. vivax in the area, genes encoding proteins relevant for ookinete development and the 18S rRNA were studied. P. vivax infectivity (percentage of infected mosquitoes and oocyst numbers) was evaluated by simultaneously feeding infected blood samples from patients to Ny. albimanus and An. pseudopunctipennis female mosquitoes. Three infectivity patterns were identified: one group of parasites were more infective to An. pseudopunctipennis than to Ny. albimanus, another group was more infective to Ny. albimanus, while a third group infected both vectors similarly. In 29 parasite isolates, the molecular variations of ookinete-specific genes and the 18S rRNA-type S were analyzed. Using concatenated sequences, phylogenetic trees, and Structure analysis, parasite clustering within SM isolates and between these and those from other geographical origins were investigated. A ML phylogenetic tree resolved two parasite lineages: PvSM-A and PvSM-B. They were associated to a different 18S rRNA variant. PvSM-A parasites had 18S rRNA variant rV2 and correspond to parasites causing high oocyst infection in Ny. albimanus. A new ML tree and Structure analysis, both comprising global sequences, showed PvSM-A clustered with Latin American parasites. Meanwhile, all isolates of PvSM-B had 18S rRNA variant rV1 and remained as unique genetic cluster comprising two subgroups: PvSM-Ba, producing high infection in An. pseudopunctipennis, and PvSM-Bb, causing similar oocyst infection in both vector species. PvSM-A parasites were genetically similar to parasites from South America.Meanwhile, PvSM-B were exclusive to southern Mexico and share ancestry with Asian parasites. The results suggest that these lineages evolved separately, likely by geographic and vector restriction.

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Section: Discussionmentioning

confidence: 99%

Section: Plasmodium Vivax Parasites and Mosquito Infectionsmentioning

confidence: 99%

Section: Plasmodium Vivax Parasites and Mosquito Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

González-Cerón¹,

Rodrı́guez²,

Ovilla-Muñoz³

et al. 2020

Front. Genet.

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“…In total, 15 distinct VK210 types were recorded and three of the more frequent variants (210A, 210B and 210E) were found in both sets of isolates, while of the remaining 12 minor variants, three were only detected in northern isolates (210C, 210D and 210F) and nine only in the south-eastern isolates. The geographical differences in distribution of the two repeat types may be related to the susceptibility of different species of anopheline vectors to infections by VK210 and VK247 variants (Gonzalez-Ceron et al 1999) and thus the prevalence of two parasite types may be correlated with the distribution of the vector species in each malaria endemic areas (Rodriguez et al 2000). The rarity of the VK247 types in the north of Iran is consistent with a study of Pvcsp diversity in 36 parasite isolates obtained from Azerbaijan, a country bordering northern Iran (Leclerc et al 2004), where only VK210 type parasites were detected.…”

Section: Discussionmentioning

confidence: 99%

Circumsporozoite protein gene diversity among temperate and tropical Plasmodium vivax isolates from Iran

Zakeri

Mehrizi

Djadid

et al. 2006

Tropical Med Int Health

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SummaryTo date, there is no information on the genetic diversity of the circumsporozoite protein (CSP), a leading vaccine candidate, in Plasmodium vivax populations circulating in Iran. The gene for this protein, Pvcsp, was amplified from 374 P. vivax isolates collected in the temperate northern, and in the tropical southern endemic areas. PCR-RFLP analysis of the repeated central region revealed that the parasites collected in the northern area were almost exclusively of the VK210 type. Parasites collected in the south-eastern areas were of both VK210 and VK247 types. We detected VK210 parasite in 70.5% of the samples, VK247 parasites in 17.5% and mixed type infections in 12% of the isolates. Sequence analysis of 137 isolates obtained from both areas identified a total of 25 distinct genotypes. The degree of genetic diversity was generally higher for the tropical (21 genotypes) than the temperate (7 genotypes) P. vivax populations, a difference possibly reflecting the high cross-border exchanges between Afghanistan and Pakistan and southern Iran. Interestingly, all but two VK210 type isolates sequenced harboured a 36-bp post-repeat insert previously only observed in North Korea and China. This large-scale survey of parasite diversity in the Eastern Mediterranean Region provides a set of baseline data suitable for future molecular epidemiological studies of P. vivax.

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“…It has been reported that VK210 is associated with higher parasitemia and chloroquine resistance (Kain et al, 1993; but see Machado and Povoa, 2000) and that year-to-year changes in the relative prevalence of VK210 and VK247 may be because of immune selection (Burkot et al, 1992). Their relative prevalence may also vary with the season (Suwanabun et al, 1994), and different sympatric species of Anopheles may be more susceptible to each (Gonzalez-Ceron et al, 1999). These contrasting characteristics seem to correspond in part to those of the "strains" discussed in the classic literature, in part to those of "strains" discussed in the recent literature (Gupta et al, 1996), and in part to neither.…”

Section: Refers Explicitly Tomentioning

confidence: 99%

Plasmodium Vivax Blood-Stage Dynamics

McKenzie¹,

Jeffery²,

Collins³

2002

Journal of Parasitology

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We examine the dynamics of parasitemia and gametocytemia reflected in the preintervention charts of 221 malaria-naive U.S. neurosyphilis patients infected with the St. Elizabeth strain of Plasmodium vivax, for malariatherapy, focusing on the 109 charts for which 15 or more days of patency preceded intervention and daily records encompassed an average 98% of the duration of each infection. Our approximations of merogony cycles (via "local peaks" in parasitemia) seldom fit patterns that correspond to "textbook" tertian brood structures. Peak parasitemia was higher in trophozoite-induced infections than in sporozoite-induced ones. Relative densities of male and female gametocytes appeared to alternate, though without a discernably regular period. Successful transmission to mosquitoes did not depend on detectable gametocytemia or on absence of fever. When gametocytes were detected, transmission success depended on densities of only male gametocytes. Successful feeds occurred on average 4.7 days later in an infection than did failures. Parasitemia was lower in homologous reinfection, gametocytemia lower or absent.

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Differential Susceptibilities of Anopheles albimanus and Anopheles pseudopunctipennis to Infections with Coindigenous Plasmodium vivax Variants VK210 and VK247 in Southern Mexico

Cited by 76 publications

References 23 publications

Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

Ookinete-Specific Genes and 18S SSU rRNA Evidenced in Plasmodium vivax Selection and Adaptation by Sympatric Vectors

Circumsporozoite protein gene diversity among temperate and tropical Plasmodium vivax isolates from Iran

Plasmodium Vivax Blood-Stage Dynamics

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