Differential suppression of endometrial prostaglandin F2alpha by the equine conceptus

Sissener, T.R.; Squires, E.L.; Clay, Colin M.

doi:10.1016/0093-691x(95)00401-s

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Culturing tissue explants, where a small piece of endometrium would be used without isolating individual cell types, was expected to overcome some of the limitations of monocultures by maintaining three-dimensional tissue architecture and thus, secretory activity of the endometrial glands. Indeed, several key studies establishing the role of PGF 2α secretion and its modulation by the presence of conceptus tissues were performed using such explants ( Vernon et al 1981 , Berglund et al 1982 , Sissener et al 1996 ). However, explants suffer from the distinct disadvantage of requiring a primary source of tissue and short lifespan.…”

Section: Enlisting New Tools: In Vitro Strategies For Endometrial Studiesmentioning

confidence: 99%

Maternal recognition of pregnancy in the mare: does it exist and why do we care?

Swegen

2021

Reproduction

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Maternal recognition of pregnancy (MRP) is a process by which an early conceptus signals its presence to the maternal system and prevents the lysis of the corpus luteum, thus ensuring a maternal milieu supportive of pregnancy continuation. It is a fundamental aspect of reproductive biology, yet in the horse, the mechanism underlying MRP remains unknown. This review seeks to address some of the controversies surrounding the evidence and theories of MRP in the equine species, such as the idea that the horse does not conform to the MRP paradigm established in other species or that equine MRP involves a mechanical, rather than chemical, signal. The review examines the challenges of studying this particularly clandestine phenomenon along with the new tools in scientific research that will drive this quest forward in coming years, and discuss the value of knowledge gleaned along this path in the context of clinical applications for improving breeding outcomes in the horse industry.

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Section: Enlisting New Tools: In Vitro Strategies For Endometrial Studiesmentioning

confidence: 99%

Maternal recognition of pregnancy in the mare: does it exist and why do we care?

Swegen

2021

Reproduction

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“…The factors contributing to this occurrence are very heterogeneous and can be as simple as the age of the mare, malnutrition, toxicosis of the maternal organism or improper timing of mating or artificial insemination (Van Niekerk 1965, Ball 1988, Darenius 1992, Brendemuehl et al 1994, Blodgett 2001). This disorder also occurs due to other numerous noninfectious causes, such as: corpus luteum insufficiency (Ball 1988, Sharp 2000, failure of maternal recognition of pregnancy as a consequence of insufficient embryonic vesicle movement (Ginther 1983, Leith andGinther 1984) or insufficient embryonal production of hormones (Weber et al 1991, 1991a, Sissener et al 1995, Herrler et al 2000. Moreover, abnormalities in the histological structure of the endometrium, e.g.…”

Section: Introductionmentioning

confidence: 99%

Polish Journal of Veterinary Sciences

Długołęcka

Tobolski

Janowski

2019

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Early embryonic death (EED) is one of the causes of infertility in the mare. We compared endometrial environment in 9 mares with EED and 13 mares in diestrus phase. Cotton swab (CS), cytobrush (CB) and uterine biopsy (B) samples were obtained for the cytological, bacteriological and histopathological examinations. In the first step we compared CS and CB methods to biopsy as a reference method, as B revealed the highest number of positive results in cytological and bacteriological examinations in both groups. In turn, we also compared cytological, bacteriological and histopathological findings between EED and control animals using the B sampling. Although the differences between these groups were not statistically significant (p≥0.05), there was a tendency to a higher prevalence of subclinical endometritis in the control group, than in the EED group (62% vs 22%). In general, positive bacteriological results were similar in both groups (62% vs 55%), whereas positive cytological results were higher in the control group (62% vs 22%; p≥0.05). In histopathological examination in EED mares endometrial degeneration was better expressed (all mares were with grades IIB and III on the Kenney-Doig scale); however, the differences between both groups were not statistically significant (p≥0.05). We could not confirm a clear difference in uterine environment between the two groups. Moreover, the uterine biopsy seemed to be the most reasonable sampling method for diagnosis of endometrial state.

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“…It is likely that PGF2a produced by the conceptus does not enter the systemic circulation but remains within the uterine lumen where it acts locally stimulating the uterine contractions necessary for embryo mobility. On the other hand, cytosol prepared from pregnant endometrium (Watson 1991), day 9 to 16 conceptuses (Sissener et al 1996), and co-incubation of endometrial explants with conceptus membranes suppressed PGF2a in vitro. Later, on days 18 and 20 of pregnancy, PGF2a concentrations in uterine flushings were similar to in non-pregnant mares on day 14.…”

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confidence: 99%

Maternal recognition of pregnancy in the horse

Katila¹

2011

PHK

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Differential suppression of endometrial prostaglandin F2alpha by the equine conceptus

Cited by 6 publications

References 14 publications

Maternal recognition of pregnancy in the mare: does it exist and why do we care?

Maternal recognition of pregnancy in the mare: does it exist and why do we care?

Polish Journal of Veterinary Sciences

Maternal recognition of pregnancy in the horse

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