Differential status and significance of non-enzymatic antioxidants (reactive oxygen species scavengers) in malaria and dengue patients

Aqeel, Sana; Naheda, Ansari; Raza, Adil; Khan, Kamran A.; Khan, Wajihullah

doi:10.1016/j.actatropica.2019.04.033

Cited by 12 publications

(21 citation statements)

References 45 publications

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“…This led to the exclusion of 317 records for various reasons, including being in vitro/in vivo studies, review articles, or conference abstracts, as well as lacking GSH information, the absence of malaria cases, not specifying GSH type, or analyzing post-treatment GSH levels. Eventually, 18 studies meeting the criteria were included in the review 14 – 20 , 31 – 41 : 12 from the primary database search 15 – 17 , 20 , 31 – 37 , 39 , five from Google Scholar 14 , 18 , 19 , 38 , 41 , and one from a reference list 40 (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis

Kotepui,

Mahittikorn

et al. 2023

Sci Rep

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Reduced glutathione (GSH) is a crucial antioxidant with recognized roles in malaria pathogenesis and host response. Despite its importance, reports on the association of GSH with malaria are inconsistent. Therefore, this systematic review and meta-analysis investigated the differences in GSH levels in relation to Plasmodium infection. A comprehensive literature search of six electronic databases (Embase, MEDLINE, Ovid, PubMed, Scopus, and ProQuest) was conducted. Of the 2158 initially identified records, 18 met the eligibility criteria. The majority of studies reported a significant decrease in GSH levels in malaria patients compared with uninfected controls, and this was confirmed by meta-analysis (P < 0.01, Hedges g: − 1.47, 95% confidence interval [CI] − 2.48 to − 0.46, I2: 99.12%, 17 studies). Additionally, there was no significant difference in GSH levels between Plasmodium falciparum malaria and P. vivax malaria (P = 0.80, Hedges g: 0.11, 95% CI − 0.76 to 0.98, I2: 93.23%, three studies). Similarly, no significant variation was observed between symptomatic and asymptomatic malaria cases (P = 0.78, Hedges g: 0.06, 95% CI − 0.34 to 0.46, I2: 48.07%, two studies). In conclusion, although GSH levels appear to be generally lower in malaria patients, further detailed studies are necessary to fully elucidate this complex relationship.

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Section: Resultsmentioning

confidence: 99%

Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis

Kotepui,

Mahittikorn

et al. 2023

Sci Rep

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“…The glutathione cycle is associated with the antioxidant metabolites and constitutes one of the core systems for preventing the adverse reaction of free radicals. Under physiological state, free radicals and other ROS namely, superoxide radicals, hydroxyl radicals and hydrogen peroxides are generated during normal metabolic processes and performs bene cial role in the body, however at elevated concentration can lead to oxidative damage and several comorbidities of chronic in ammatory and immune system dysregulation most especially during Plasmodium parasite infection in animal and clinical trial (Aqeel et al, 2019). Interestingly, the combination of black seed supplemented diet and chloroquine (CQ) caused a notable suppression of free radicals production via the elevation of antioxidant enzyme, glutathione peroxidase (Gpx) in the plasma and liver of P.berghei infected mice.…”

Section: Discussionmentioning

confidence: 99%

Effect of black seeds ( Nigella sativa ) on inflammatory and immunomodulatory markers in Plasmodium berghei ‐infected mice

Ojueromi

Oboh

Ademosun

2022

Journal of Food Biochemistry

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N.sativa, a core dietary supplement and food additive in folklore is one of the most broadly studied seed plants in the global nutraceutical sector. Malaria infection impairs the ability of principal cells of the immune system to trigger an e cient in ammatory and immune response. Ninety-six mice weighing (20-25g) were grouped into twelve consisting of eight animals each. The mice were infected with standard inoculum of the strain NK65 P.berghei (chloroquine sensitive) and the percentage parasitemia suppression were evaluated. The individual effect of black seed supplemented diet and its combinatory effect with chloroquine (CQ) were investigated on the glutathione peroxidase(GPx), reduced glutathione(GSH), glutathione-S-transferase (GST), serum immunoglobulins (IgG and IgM), and the hematological parameters (haemoglobin, packed cell volume and red blood cell count) in P.berghei infected mice. The in ammatory cytokines; Tumor necrosis factor (TNF-α), C-reactive protein (CRP), Interleukin (IL-6 and IL-10) as well as IgG and IgM were assayed in the serum. The mice temperature and behavioural changes were observed. Infected mice treated with the dietary supplementation of black seed with a percentage inclusion (2.5%, 5% and 10%) showed signi cantly decreased parasitemia levels (p<0.05) compared with the untreated mice. The result demonstrated a signi cant suppression in the proin ammatory cytokines (TNF-α, CRP, IL-6) levels and a notable elevation in the anti-in ammatory cytokine (IL-10), antioxidant markers as well as the immunoglobulin levels of the P.berghei-infected mice treated with black seed. The study revealed that black seed enhanced host antioxidant status, modulated in ammatory and immune response by regulating some in ammatory cytokines and immunomodulatory mediators. Pratical ApplicationBlack seed (N.sativa) has been a dietary supplement and natural remedy for many ailments for many centuries. In ammatory and immune diseases are the most notable cause of mortality in the world and more than fty percent of deaths have been attributed to it. However, there's paucity of information on the effect of N.sativa on anti-in ammatory and immunomodulatory ability of N.sativa. The result suggests that N.sativa induced antioxidant, anti-in ammatory and immunomodulatory effect in P.bergheiinfected mice via the participation of glutathione antioxidant system, serum antibodies and some in ammatory cytokines.2.7 Grouping of Experimental Animals. Group 1: Normal control (Mice fed with basal diet) Group 2: Plasmodium berghei-infected mice (PBIM) Group 3: PBIM + chloroquine (CQ) (10 mg/kg)

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“…The levels of non-enzymatic antioxidants and the total antioxidant status (TAS) in patients with malaria and dengue were evaluated, and an increase in GSH levels was observed in dengue and P. falciparum malaria; however, there was a reduction in ascorbate levels in both cases [ 139 ]. In another study, the levels of GSH and ascorbic acid were reduced, being associated with increased MDA in patients with uncomplicated P. falciparum malaria [ 34 ].…”

Section: Oxidative Stress In the Host Induced By Plasmodiummentioning

confidence: 99%

Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy

Gomes

Cunha

Varela

et al. 2022

IJMS

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Malaria is an infectious disease and a serious public health problem in the world, with 3.3 billion people in endemic areas in 100 countries and about 200 million new cases each year, resulting in almost 1 million deaths in 2018. Although studies look for strategies to eradicate malaria, it is necessary to know more about its pathophysiology to understand the underlying mechanisms involved, particularly the redox balance, to guarantee success in combating this disease. In this review, we addressed the involvement of oxidative stress in malaria and the potential benefits of antioxidant supplementation as an adjuvant antimalarial therapy.

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Differential status and significance of non-enzymatic antioxidants (reactive oxygen species scavengers) in malaria and dengue patients

Cited by 12 publications

References 45 publications

Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis

Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis

Effect of black seeds ( Nigella sativa ) on inflammatory and immunomodulatory markers in Plasmodium berghei ‐infected mice

Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy

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