Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages
See Jie Yow,
Safwah Nasuha Rosli,
Paul E. Hutchinson
et al.
Abstract:TLR4 and TNFR1 signalling promotes potent proinflammatory signal transduction events, thus, are often hijacked by pathogenic microorganisms. We recently reported that myeloid cells retaliate Yersinia blockade of TAK1/IKK signalling by triggering RIPK1-dependent caspase-8 activation that promotes downstream GSDMD and GSDME-mediated pyroptosis in macrophages and neutrophils respectively. However, the upstream signalling events for RIPK1 activation in these cells are not well defined. Here, we demonstrate that un… Show more
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