Differential sensitivity of the caudal and rostral nucleus accumbens to the rewarding effects of a H1-histaminergic receptor blocker as measured with place-preference and self-stimulation behavior

Zimmermann, Petra K; Privou, Caroline; Huston, Joseph P.

doi:10.1016/s0306-4522(99)00309-7

Cited by 44 publications

(20 citation statements)

References 54 publications

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“…However, the appetitive opioid eating site of Peciña and Berridge (ϩ1.0 to ϩ2.2 mm anterior to bregma) also extended posteriorly into our caudal shell region in which GABAergic muscimol elicited negative defensive burying. An overlap between positive and negative motivational systems in caudal shell is also consistent with our previous finding using a pure conditioned incentive paradigm that amphetamine microinjection in this same caudal shell site increases appetitive cue-triggered bar pressing for a sucrose reward (Wyvell and Berridge, 2000) and with findings of greatest reward effects in place preference and brain self-stimulation paradigms after histamine receptor blockade in the caudal shell (Zimmermann et al, 1999). These comparisons indicate that positivenegative function is determined interactively by neurochemical receptor activation, as well as by neuroanatomical localization of function within the nucleus accumbens shell.…”

Section: Functional Interaction Between Neuroanatomical and Neurochemsupporting

confidence: 77%

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

2001

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This study examined localization of positive versus negative motivational functions mediated by GABA circuits within the accumbens shell. Microinjections of a GABA A agonist (0, 25, 75, and 225 ng/0.5 l muscimol) in rostral shell sites elicited appetitive increases in eating behavior. In contrast, microinjections in caudal shell sites elicited defensive burying or pawtreading behavior. Rats whose microinjections landed bilaterally outside of the accumbens shell did not display either behavior. Defensive treading elicited by caudal shell muscimol microinjection appeared to be a negative motivated response to threat (similar in parameters and orientation to normal defensive burying of a threatening electrified shock prod). The nucleus accumbens shell thus appears functionally heterogeneous in coding motivational valence. The demonstration that muscimol elicits positive eating behavior from rostral shell versus negative defensive behavior from caudal shell suggests in particular that GABAergic substrates of positive and negative types of motivated behavior in the nucleus accumbens shell are segregated along a rostrocaudal gradient.Key words: accumbens shell; GABA; food intake; reward; appetite; motivation; glutamate; dopamine; fear; defense; aggression; mesolimbic; microinjection GABAergic medium spiny neurons in the nucleus accumbens shell are implicated in the control of appetitive behavior and reward. Regarding eating behavior specifically, robust increases in food intake by rats are elicited by microinjection in the medial accumbens shell of either GABA A or GABA B receptor agonists (or non-NMDA glutamate antagonists) (Maldonado-Irizarry et al., 1995;Stratford and Kelley, 1997;Basso and Kelley, 1999).Aside from its role in positive appetitive behavior, the accumbens shell has also been implicated in negative motivational states, such as stress, fear, and defensive behavioral responses elicited by noxious or threatening stimuli (Inoue et al

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Section: Functional Interaction Between Neuroanatomical and Neurochemsupporting

confidence: 77%

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

2001

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“…The relative lack of an effect of lesions of the NAcc shell region on heroin self-administration may appear unexpected, given the suggestion of a direct or indirect role for the shell in mediating the reinforcing and some other effects of drugs of abuse (Robledo and Koob 1993;Carlezon et al 1995;Johnson et al 1995;Carlezon and Wise 1996;Nisell et al 1997;Hedou et al 1999;Parkinson et al 1999a;Zimmerman et al 1999). Increased DA levels and glucose metabolism in the shell of NAcc, as compared with the core, are seen following morphine administration (Pontieri et al 1995;Orzi et al 1996), and this has been taken to indicate that the nucleus accumbens shell is involved in heroin reinforcement.…”

Section: Discussionmentioning

confidence: 90%

The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats

et al. 2000

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“…Thus, the present analysis also appears to identify both striatopallidal and extended amygdaloid properties within the caudomedial accumbens shell and thus neither strongly confirms nor refutes the point of view that the AcbS is a transition zone. Nonetheless, the overall neurochemical and hodological complexion of the AcbS is sufficiently distinct that it seems quite reasonable to regard it as a unique processing region, particularly because this assessment is supported by studies of emotional and motivational behaviors (Zimmermann et al, 1999;Reynolds and Berridge, 2002).…”

Section: Acbs As a Transition Zonementioning

confidence: 99%

Specificity in the Projections of Prefrontal and Insular Cortex to Ventral Striatopallidum and the Extended Amygdala

2005

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The basal forebrain functional-anatomical macrosystems, ventral striatopallidum, and extended amygdala are innervated by substantially coextensive distributions of neurons in the prefrontal and insular cortex. This suggests two alternative organizational schemes: convergent, in which a given cortical area projects exclusively to only one of these macrosystems and divergent, in which a given cortical area innervates both forebrain macrosystems. To examine the underlying organization and possibly discriminate between these alternatives, rats were injected with two retrograde tracers in different parts of ventral striatopallidum or extended amygdala (homotypic injection pairs) or with one tracer in each macrosystem (heterotypic). The prefrontal and insular cortex was evaluated microscopically for overlap of retrograde labeling and double labeling of neurons. Homotypic injection pairs in the ventral striatum and extended amygdala produced extensive overlap of retrogradely labeled neurons and significant double labeling, suggesting that cortical projections spread broadly within macrosystems. In contrast, heterotypic injection pairs produced significant overlap of retrograde labeling but negligible double labeling, indicating that ventral striatopallidum and extended amygdala receive inputs from separate sets of prefronto-and insular cortical neurons. The caudomedial shell of the nucleus accumbens, a supposed "transition" zone between striatopallidum and extended amygdala, had extended amygdala-like afferents but produced few double-labeled neurons and these only when paired with ventral striatopallidum. The data suggest that a modular organization of the basal forebrain, with postulated independent information processing by the ventral striatopallidal and extended amygdala macrosystems, is reflected in a corresponding segregation of output neurons in the prefrontal and insular cortices.

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Differential sensitivity of the caudal and rostral nucleus accumbens to the rewarding effects of a H1-histaminergic receptor blocker as measured with place-preference and self-stimulation behavior

Cited by 44 publications

References 54 publications

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats

Specificity in the Projections of Prefrontal and Insular Cortex to Ventral Striatopallidum and the Extended Amygdala

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