Differential scanning calorimetry study of early and advanced stages in Parkinson’s disease using human blood serum

Modification of blood serum DSC profiles by sauna treatments in cross-country skiers during the exercise cycle

“…The thermal denaturation of the proteins contained in the blood sera is observed in serum DSC profile as complex endothermic transition. At first sight, at least two or three peaks can be distinguished in this transition for healthy people, depending on the serum proteome and the solvent used [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Mean DSC curves of aqueous solutions of human blood sera samples collected from participants of our study at three time points (before sauna treatments, after 1 sauna treatment and after 10 sauna treatments) are shown in Fig.…”

“…Differential scanning calorimetry (DSC) has found wide application in medical and biological sciences [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Attempts to use the DSC method for clinical purposes have been made for several years [15][16][17][18][19][20][21][22][23][24][25][26][27]. DSC profiles of blood serum, plasma, synovial fluid, cerebrospinal fluid are very useful because they can be a valuable source of information about alterations in these physiological fluids caused by different diseases or treatments.…”

Whole-body cryostimulation impact on blood serum thermal denaturation profiles of cross-country skiers

“…This transition is irreversible. Usually, two or three main peaks can be distinguished in the DSC profile of healthy human blood serum, depending on the solvent used [14][15][16][17][18][19][20][21][22][23][24][25][26].…”

“…DSC profiles of biological fluids can be a source of valuable information about the health of patients as well as athletes [15][16][17][18][19][20][21][22][23][24][25][26][27]. The DSC method was used in patients with multiple disease entities [15][16][17][18][19][20][21][22][23][24]. The branch of research among athletes is just developing [25][26][27].…”

Comparison of human blood serum DSC profiles in aqueous and PBS buffer solutions

“…Recently, it has been recognized as having potential in diagnostics and monitoring of diseases. DSC has been used to characterize thermal denaturation transitions in various biological fluids, in particular, blood plasma [1][2][3][4][5][6][7][8][9], serum [10][11][12][13][14][15][16], synovial fluid [17][18][19], cerebrospinal fluid [20,21]. This highly sensitive method allows detecting, registering and analysis the changes taking place in various diseases, during treatment, after high-intensity exercise or because of other efforts and stressors .…”