Differential scanning calorimetric examination of the human hyaline cartilage

Than, Péter; Vermes, Cs; Schäffer, B.; Lőrinczy, D.

doi:10.1016/s0040-6031(99)00392-5

Cited by 34 publications

(11 citation statements)

References 8 publications

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“…The reported data on the calorimetric enthalpy changes proved to be inconsistent. In severely affected osteoarthritis, the ΔH has increased almost twofold, while in an earlier study, enthalpy changes in the intact hyaline cartilage altered from higher to lower levels in some cases [Than et al, 2000;Than et al, 2004]. The aim of these studies was to further characterize the altered metabolisms in OA that promotes disease progression.…”

Section: Introductionmentioning

confidence: 98%

“…enthalpy changes for reactions (ΔH) and for phase changes Than & Lőrinczy, 2003]. The usefulness of calorimetric examination in the characterization of biological samples has been demonstrated by previous studies [Than et al, 2000;Wiegand et al, 2009]. Prior studies have demonstrated the usefulness of calorimetric examination in the characterization of cartilage degeneration [Wiegand et al, 2010].…”

Section: Introductionmentioning

confidence: 99%

“…An increasing number of papers have been published with the use of calorimetric techniques in the examination of degenerative [Mécs et al, 2009], rheumatoid arthritis , and healthy human hyaline cartilage . P. Than et al investigated first animal hyaline cartilage using differential scanning calorimetric method [Than et al, 2000]. They have concluded that structural manifestation of OA causes a remarkable change of thermal stability of hyaline cartilage.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of Live and Experimentally Degenerated Hyaline Cartilage with Thermal Analysis

Sohár¹,

Szabó‐Révész²,

Tóth³

et al. 2012

Osteoarthritis - Diagnosis, Treatment and Surgery

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of Live and Experimentally Degenerated Hyaline Cartilage with Thermal Analysis

Sohár¹,

Szabó‐Révész²,

Tóth³

et al. 2012

Osteoarthritis - Diagnosis, Treatment and Surgery

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“…Previously differential scanning calorimetry (DSC) was used for the investigation of normal and degenerative human meniscus cartilage, and water content has not been measured [11][12][13][14]. A significant paper from this field was the study of Than et al [15], further studies measured the difference between primary osteoarthritis and septic arthritis [16]. Most of the known changes in the extracellular matrix in OA come from animal models, because human samples are only available for experiment to a limited extent.…”

Section: Introductionmentioning

confidence: 99%

Thermogravimetric Investigation of Normal and Pathological Human Meniscus

Gálity¹,

Aigner²

2015

J Thermodyn Catal

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“…The con cept of the re search pro gram has been set up in co op er a tion be tween the In sti tutes of Bio phys ics, Pa thol ogy and the De part ment of Or tho pe dics of the Med i cal School of the Uni ver sity of Pécs [10][11][12][13].…”

Section: Dsc Of the Hyaline Cartilage In Rabbitsmentioning

confidence: 99%

DSC examination of the musculosceletal system

Than

Domán

Lőrinczy

Hot Topics in Thermal Analysis and Calorimetry

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DSC examination of the hyaline cartilage THE HYALINE CARTILAGE Characteristic features of the normal hyaline cartilageCon nec tive and sup port ive tis sues of the hu man body are char ac ter ized by the large amount of ba sic sub stances fill ing the gap be tween cells and sig nif i cantly in flu enc ing the me chan i cal prop er ties of the tis sue. In op po site to the con nec tive tis sues -where the ground sub stance is mainly formed by fi bers -in case of support ive tis sues, like for ex am ple car ti lage, other or ganic and in or ganic ma te ri als are typ i cal for the ba sic sub stance.Car ti lage it self is a tis sue where a rel a tively lit tle num ber of bub ble-like cells is bed ded in an elas tic but also strong ba sic sub stance. Be cause of this struc ture car ti lage is very re sis tant against com pres sion forces, but hardly withstands shear ing stresses. The most rigid form is the hyaline type cartilage, covering the ar tic u lat ing sur faces of bones. This car ti lage type has a ho mog enous ba sic sub stance, which sur rounds groups of 2-4 cells hav ing a very char acter is tic form. The plasma of these cells con tains a large amount of gly co gen and lit tle fat bub bles. The ground sub stance has a fi brous frame built of II-type colla gen. Within this frame com plex pro teins (proteoglycan) are placed, which con tain a large amount of chondroitin sul fate, later be ing the most typ i cal compo nent of hyaline car ti lage. The rest of the ground sub stance is com posed of inor ganic ma te ri als and in 70-80% of wa ter.The col la gen-proteoglycan ma trix serves as the me chan i cal frame of the car ti lage and si mul ta neously de ter mines its me chan i cal prop er ties [1]. The colla gen fi bers hav ing a tri ple he lix form are re spon si ble for ten sile strength while proteoglycans are re spon si ble for com press ibil ity. Hyaline car ti lage is a tis sue hav ing a com plex and ac tive me tab o lism from the bio chem i cal point of view.

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Differential scanning calorimetric examination of the human hyaline cartilage

Cited by 34 publications

References 8 publications

Characterization of Live and Experimentally Degenerated Hyaline Cartilage with Thermal Analysis

Characterization of Live and Experimentally Degenerated Hyaline Cartilage with Thermal Analysis

Thermogravimetric Investigation of Normal and Pathological Human Meniscus

DSC examination of the musculosceletal system

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