Differential Satiating Effects of Fats in the Small Intestine of Obesity-Resistant and Obesity-Prone Rats

Greenberg, Danielle; McCaffery, Jeanne M.; Potack, Jonathan; Bray, George A.; York, David A.

doi:10.1016/s0031-9384(98)00336-9

Cited by 39 publications

(34 citation statements)

References 16 publications

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“…Other data also suggest a difference in the response to fatty acids in the two strains. The OM rat has an attenuated activity of the fatty acid-sensitive K ϩ rectifier channel in the taste buds compared with the S5B/Pl rat (7) and an attenuated anorectic response when oleic acid is infused into the duodenum (8). The data suggest that differences in the oxidation of fatty acids or the response to fatty acid signals may account for the difference in susceptibility to obesity between these strains when eating a HF diet.…”

Section: Introductionmentioning

confidence: 87%

Effects of a High‐Fat Diet and Strain on Hypothalamic Gene Expression in Rats

et al. 2002

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Effects of a high-fat diet and strain on hypothalamic gene expression in rats. Obes Res. 2002;10:1188 -1196. Objective: This study was designed to investigate whether dietary fat and genetic background might differentially alter the expression of hypothalamic genes involved in food intake. Research Methods and Procedures: Three-month-old Osborne-Mendel (OM) and S5B/Pl rats were fed either a high-fat or a low-fat diet for 14 days. mRNA for neuropeptide Y (NPY), corticotrophin-releasing hormone, NPY Y-1 receptor and Y-5 receptor, and serotonin 2c (5-HT2c) receptors were measured using Northern blotting or ribonuclease protection assays. Results: OM rats showed an increased expression of NPY and corticotrophin-releasing hormone compared with S5B/Pl rats. The expression of NPY-Y1 and -Y5 receptor mRNA was significantly higher in the hypothalamus of OM rats compared with S5B/Pl rats. The expression of 5HT-2c receptor mRNA was significantly reduced in both strains of rats eating a high-fat diet when compared with the animals eating the low-fat diet. Discussion: These data suggest that over activity of the NPY system may contribute to the development of obesity in OM rats and that expression of the 5HT-2c receptor gene may be modulated by dietary fat.

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Section: Introductionmentioning

confidence: 87%

Effects of a High‐Fat Diet and Strain on Hypothalamic Gene Expression in Rats

et al. 2002

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“…As such, obesity is often associated with reduced responsiveness to intraintestinal nutrients, especially fats. For example, obese Zucker (130), Otsuka Long Evans Tokushima Fatty (OLETF) (47,193), Osborne-Mendel (OM) (87), and high-calorie-fed obese rats (210) have all been reported to be less sensitive to reduction of food intake by fats. Reduced sensitivity to the satiating effects of fats is also manifest in animals maintained on an HF, nonobesogenic diet.…”

Section: Hf Diets Diminish Appetite Responses To Lipidsmentioning

confidence: 99%

“…These animals have numerous differences in feeding behavior involving orexigenic and anorexigenic signals, as well as GI and central systems (13,87,125,197,233). The OM rat is hyperphagic and obese relative to S5B controls after introduction to an HF diet.…”

Section: Dio and Dietary-resistant Ratsmentioning

confidence: 99%

Deficits in gastrointestinal responses controlling food intake and body weight

Covașă

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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The gastrointestinal tract serves as a portal sensing incoming nutrients and relays mechanical and chemosensory signals of a meal to higher brain centers. Prolonged consumption of dietary fat causes adaptive changes within the alimentary, metabolic, and humoral systems that promote a more efficient process for energy metabolism from this rich source, leading to storage of energy in the form of adipose tissue. Furthermore, prolonged ingestion of dietary fats exerts profound effects on responses to signals involved in termination of a meal. This article reviews the effects of ingested fat on gastrointestinal motility, hormone release, and neuronal substrates. It focuses on changes in sensitivity to satiation signals resulting from chronic ingestion of high-fat diet, which may lead to disordered appetite and dysregulation of body weight.

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“…A alta palatabilidade da dieta hiperlipídica é considerada um dos fatores desencadeadores da hiperfagia dos animais tratados com esse tipo de ração 11 . No entanto, existem diferenças na preferência alimentar entre ratos propensos e resistentes à obesidade.…”

Section: N T R O D U ç ã Ounclassified

Dieta hiperlipídica com farinha de soja como fonte proteica: utilização na seleção de ratos propensos e resistentes à obesidade

et al. 2010

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OBJETIVO: Desenvolver uma dieta hiperlipídica de baixo custo, tendo farinha de soja como fonte proteica, que seja eficiente na seleção de ratos propensos e resistentes à obesidade e que permita alcançar fenótipo obeso nos animais propensos. Além desses requisitos, a dieta deve ser palatável e não rejeitada a curto prazo pelo animal. MÉTODOS: A dieta proposta foi obtida misturando-se leite condensado (15,5%), amendoim (18,5%), farinha de soja (20,0%), óleo de milho (6,0%), ração Bio Tec (30,0%) e bolacha wafer de chocolate (10,0%). A mistura foi peletizada e submetida à análise bromatológica. A dieta foi ofertada a ratos Wistar durante uma semana; posteriormente, os animais foram divididos em três grupos, de acordo com o ganho de peso. O terço superior foi considerado propenso à obesidade e o terço inferior, resistente à obesidade. Após 80 dias de oferta da dieta, os animais foram sacrificados e foram quantificados o peso corpóreo, consumo alimentar, gorduras retroperitoneal, periepididimal, de carcaça e gorduras totais. RESULTADOS: Verificou-se que a dieta apresentava 5,31kcal/g, com a seguinte composição: 22,3% de gordura, 22,2% de proteína, 15,9% de fibra, estimando-se 35,7% de carboidrato. Ratos propensos à obesidade, alimentados por 87 dias com a dieta hipercalórica, apresentaram peso corpóreo, gorduras retroperitoneal, periepididimal e totais significativamente maiores do que animais resistentes à obesidade (p<0,05). O consumo de alimentos também foi maior em animais propensos (p<0,05). Verificou-se também que a substituição da caseína pela farinha de soja, como componente proteico da ração, levou à diminuição de 96,0% no custo do estudo. CONCLUSÃO: A dieta formulada com farinha de soja apresentou custo reduzido e foi capaz de desenvolver o fenótipo obeso em ratos propensos, à semelhança do observado na literatura com outras dietas.

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Differential Satiating Effects of Fats in the Small Intestine of Obesity-Resistant and Obesity-Prone Rats

Cited by 39 publications

References 16 publications

Effects of a High‐Fat Diet and Strain on Hypothalamic Gene Expression in Rats

Effects of a High‐Fat Diet and Strain on Hypothalamic Gene Expression in Rats

Deficits in gastrointestinal responses controlling food intake and body weight

Dieta hiperlipídica com farinha de soja como fonte proteica: utilização na seleção de ratos propensos e resistentes à obesidade

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