Differential Roles of Ventral and Dorsal Streams for Conceptual and Production-Related Components of Tool Use in Acute Stroke Patients

Martin, Markus; Beume, Lena-Alexandra; Kümmerer, Dorothee; Schmidt, Corina; Bormann, Tobias; Dreßing, Andrea; Ludwig, Vera M.; Umarova, Roza; Mader, Irina; Rijntjes, Michel; Kaller, Christoph P.; Weiller, Cornelius

doi:10.1093/cercor/bhv179

Cited by 63 publications

(58 citation statements)

References 134 publications

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“…Another possibility is that the pantomime is subserved by a widely distributed network in the left hemisphere, including premotor and parietal cortices together with 15 connecting fiber tracts, which could not be analyzed by MVPA. More recent studies with a larger sample of acute stroke patients showed that the IPL is responsible for pantomime integrity (Hoeren et al 2014;Martin et al 2015;Martin et al 2016), which is in accordance with the present finding.…”

Section: Iplsupporting

confidence: 92%

Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Ogawa

Imai

2016

Exp Brain Res

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Previous neuropsychological studies of ideomotor apraxia (IMA) indicated impairments in pantomime actions for tool use for both right and left hands following lesions of parieto-premotor cortices in the left hemisphere. Using functional magnetic resonance imaging (fMRI) with multi-voxel pattern analysis (MVPA), we tested the hypothesis that 5 the left parieto-premotor cortices are involved in the storage or retrieval of hand-independent representation of tool use actions. In the fMRI scanner, one of three kinds of tools was displayed in pictures or letters, and the participants made pantomimes of the use of these tools using the right hand for the picture stimuli or with the left hand for the letters. We then used MVPA to classify which kind of tool the subjects were pantomiming. 10Whole-brain searchlight analysis revealed successful decoding using the activities largely in the contralateral primary sensorimotor region, ipsilateral cerebellum, and bilateral early visual area, which may reflect differences in low-level sensorimotor components for three types of pantomimes. Furthermore, a successful cross-classification between the right and left hands was possible using the activities of the left inferior parietal lobule (IPL) near the 15 junction of the anterior intraparietal sulcus. Our finding indicates that the left anterior intraparietal cortex plays an important role in the production of tool-use pantomimes in a hand-independent manner, and independent of stimuli modality.

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Section: Iplsupporting

confidence: 92%

Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Ogawa

Imai

2016

Exp Brain Res

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“…Other studies reported the involvement of the left ventral premotor cortex (Chao & Martin, ; Grafton, Fadiga, Arbib, & Rizzolatti, ; Kroliczak & Frey, ), the left inferior frontal gyrus (IFG) bordering pars opercularis (e.g., see Johnson‐Frey et al, ), and the left insula (Brandi et al, ) when participants viewed tool images or were instructed to process the appropriate manner with which to grasp or manipulate objects. Neuropsychological evidence consistent with those fMRI findings suggests that lesions to the left IFG and adjacent structures in the insula impair the ability to select the appropriate manner with which to grasp or use an object (e.g., see Watson & Buxbaum, ; see also Goldenberg, Hermsdorfer, Glindemann, Rorden, & Karnath, ; Martin et al, ).…”

Section: Introductionmentioning

confidence: 68%

Gesturing tool use and tool transport actions modulates inferior parietal functional connectivity with the dorsal and ventral object processing pathways

Garcea

Buxbaum

2019

Human Brain Mapping

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Interacting with manipulable objects (tools) requires the integration of diverse computations supported by anatomically remote regions. Previous functional neuroimaging research has demonstrated the left supramarginal (SMG) exhibits functional connectivity to both ventral and dorsal pathways, supporting the integration of ventrally‐mediated tool properties and conceptual knowledge with dorsally‐computed volumetric and structural representations of tools. This architecture affords us the opportunity to test whether interactions between the left SMG, ventral visual pathway, and dorsal visual pathway are differentially modulated when participants plan and generate tool‐directed gestures emphasizing functional manipulation (tool use gesturing) or structure‐based grasping (tool transport gesturing). We found that functional connectivity between the left SMG, ventral temporal cortex (bilateral fusiform gyri), and dorsal visual pathway (left superior parietal lobule/posterior intraparietal sulcus) was maximal for tool transport planning and gesturing, whereas functional connectivity between the left SMG, left ventral anterior temporal lobe, and left frontal operculum was maximal for tool use planning and gesturing. These results demonstrate that functional connectivity to the left SMG is differentially modulated by tool use and tool transport gesturing, suggesting that distinct tool features computed by the two object processing pathways are integrated in the parietal lobe in the service of tool‐directed action.

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“…However, the lesions associated with gesture deficits included lesions associated with imitation deficits, including slightly ventral areas (orbital part of the IFG and temporal pole of the superior temporal gyrus). Imitation is possible with simple visual-motor conversion, whereas gesture from verbal instruction requires semantic processing, and the ventral regions are more involved (100, 117). The current findings were consistent with the results of these previous studies and showed that the visuo-motor conversion region and semantic processing region overlap, but do not completely match.…”

Section: Discussionmentioning

confidence: 99%

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

et al. 2018

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Limb apraxia is a higher brain dysfunction that typically occurs after left hemispheric stroke and its cause cannot be explained by sensory disturbance or motor paralysis. The comparison of motor signals and visual feedback to generate errors, i.e., visuo-motor integration, is important in motor control and motor learning, which may be impaired in apraxia. However, in apraxia after stroke, it is unknown whether there is a specific deficit in visuo-motor temporal integration compared to visuo-tactile and visuo-proprioceptive temporal integration. We examined the precision of visuo-motor temporal integration and sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration in apraxia after stroke by using a delayed visual feedback detection task with three different conditions (tactile, passive movement, and active movement). The delay detection threshold and the probability curve for delay detection obtained in this task were quantitative indicators of the respective temporal integration functions. In addition, we performed subtraction and voxel-based lesion-symptom mapping to identify the brain lesions responsible for apraxia and deficits in visuo-motor temporal integration. The behavioral experiments showed that the delay detection threshold was extended and that the probability curve for delay detection was less steep in apraxic patients compared to controls (pseudo-apraxic patients and unaffected patients), only for the active movement condition, and not for the tactile and passive movement conditions. Furthermore, the severity of apraxia was significantly correlated with the delay detection threshold and the steepness of the probability curve in the active movement condition. These results indicated that multisensory (i.e., visual, tactile, and proprioception) feedback was normally temporally integrated, but motor prediction and visual feedback were not correctly temporally integrated in apraxic patients. That is, apraxic patients had difficulties with visuo-motor temporal integration. Lesion analyses revealed that both apraxia and the distortion of visuo-motor temporal integration were associated with lesions in the fronto-parietal motor network, including the left inferior parietal lobule and left inferior frontal gyrus. We suppose that damage to the left inferior fronto-parietal network could cause deficits in motor prediction for visuo-motor temporal integration, but not for sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration, leading to the distortion of visuo-motor temporal integration in patients with apraxia.

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Differential Roles of Ventral and Dorsal Streams for Conceptual and Production-Related Components of Tool Use in Acute Stroke Patients

Cited by 63 publications

References 134 publications

Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Gesturing tool use and tool transport actions modulates inferior parietal functional connectivity with the dorsal and ventral object processing pathways

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

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