Differential roles of prelimbic and infralimbic cholinergic neurotransmissions in control of cardiovascular responses to restraint stress in rats

Role of cortical–brainstem circuitry in physiological responses to stress: perspectives for non‐invasive brain stimulation

“…Similarly, Oliveira et al. (2022) showed that cholinergic neurotransmission within vPL is involved in stress‐evoked tachycardia, while the local cholinergic activation within PL mediates the pressor response and cutaneous vasoconstriction triggered by acute restraint stress, without affecting the tachycardia response. Based on these lines of evidence, it could have been beneficial for the authors to also have limited viral injection solely into these vPL and IL regions of PFC, and compared their role in regulating the physiological responses to stress.…”

“…It has been suggested that subdivisions of vmPFC may play different roles in mediating the expression of physiological responses to stress. For example, microinjection of a non-specific synaptic inhibitor into PL increased while synaptic blockade within IL attenuated the tachycardia response induced by acute stress, suggesting that the vPL cortex would exert an inhibitory influence in the regulation of the cardiovascular and HPA systems during exposure to acute stress, whereas the IL cortex would enhance the expression of these responses (Oliveira et al, 2022;Tavares et al, 2009). Similarly, Oliveira et al (2022) showed that cholinergic neurotransmission within vPL is involved in stress-evoked tachycardia, while the local cholinergic activation within PL mediates the pressor response and cutaneous vasoconstriction triggered by acute restraint stress, without affecting the tachycardia response.…”

“…It has been suggested that subdivisions of vmPFC may play different roles in mediating the expression of physiological responses to stress. For example, microinjection of a non‐specific synaptic inhibitor into PL increased while synaptic blockade within IL attenuated the tachycardia response induced by acute stress, suggesting that the vPL cortex would exert an inhibitory influence in the regulation of the cardiovascular and HPA systems during exposure to acute stress, whereas the IL cortex would enhance the expression of these responses (Oliveira et al., 2022; Tavares et al., 2009). Similarly, Oliveira et al.…”

“…For example, microinjection of a non-specific synaptic inhibitor into PL increased while synaptic blockade within IL attenuated the tachycardia response induced by acute stress, suggesting that the vPL cortex would exert an inhibitory influence in the regulation of the cardiovascular and HPA systems during exposure to acute stress, whereas the IL cortex would enhance the expression of these responses (Oliveira et al, 2022;Tavares et al, 2009). Similarly, Oliveira et al (2022) showed that cholinergic neurotransmission within vPL is involved in stress-evoked tachycardia, while the local cholinergic activation within PL mediates the pressor response and cutaneous vasoconstriction triggered by acute restraint stress, without affecting the tachycardia response. Based on these lines of evidence, it could have been beneficial for the authors to also have limited viral injection solely into these vPL and IL regions of PFC, and compared their role in regulating the physiological responses to stress.…”