Differential Roles of Endogenous Nitric Oxide on Neural Regulation of Basal Exocrine Pancreatic Secretion in Intact and Denervated Pancreas

Zoucas, Evita; Nilsson, Carina; Ihse, Ingemar

doi:10.1159/000055800

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Both these effects were believed to be Ca 2ϩ dependent and possibly mediated by cyclic guanosine monophosphate (cGMP) (38). This dual effect on isolated, extrinsically denervated rat pancreata was also observed by Zoucas et al (220) suggesting that intrapancreatic nitric oxide release was regulated by extrapancreatic nerves.…”

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 64%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

103

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Although the role of the islets in the regulation of acinar cell function seemed a mystery to investigators who observed their dispersion among pancreatic acini, over time an appreciation for this intricate and unique structural arrangement has developed. The last three decades have witnessed a steadily growing understanding of the interrelationship of the endocrine and the exocrine pancreas. The islet innervation and vascular anatomy have been more fully characterized and provide an appropriate background for our current understanding. The interrelationship between the endocrine and exocrine pancreas is mediated by islet-derived hormones such as insulin and somatostatin, other humoral factors including pancreastatin and ghrelin, and also neurotransmitters (nitric oxide, peptide YY, substance P, and galanin) released by the nerves innervating the pancreas. Although considerable progress has been achieved, further work is required to fully delineate the complex interplay of the numerous mechanisms involved. This review aims to provide a comprehensive update of the current literature available, bringing together data gleaned from studies addressing the actions of individual hormones, humoral factors, and neurotransmitters on the regulation of amylase secretion from the acinar cell. This comprehensive view of the islet-acinar axis of the pancreas while acknowledging the dominant role played by insulin and somatostatin on exocrine secretion sheds light on the influence of the various neuropeptides on amylase secretion.

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Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 64%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

103

View full text Add to dashboard Cite

show abstract

“…This may include vasculature, nervous, endocrine cells and other NO producers/targets. The effects of NO were shown to be influenced by the site of NO generation, the amount of NO produced, and depended on the specific NOS isoforms involved in NO synthesis (Vaquero et al 1998;Zoucas et al 2001;DiMagno et al 2004a).…”

Section: No and Pancreatic Acinar Cell Functionmentioning

confidence: 99%

“…Studies in vivo suggest a positive influence of NO upon pancreatic secretion. Inhibition of endogenous NO synthesis decreased stimulated secretion of pancreatic enzymes in rats (Konturek et al 1994;Molero et al 1995;Vaquero et al 1998;Jyotheeswaran et al 2000;Zoucas et al 2001), mice (DiMagno et al 2004a, pigs (Holst et al 1994), humans (Konturek et al 1997), cats (Patel et al 1995) and dogs (Konturek et al 1993). NOS blockade was also shown to suppress basal zymogen secretion in fasting dogs (Maczka et al 1994) and rats (Vaquero et al 1998), although no effect was observed in mice (DiMagno et al 2004a) and fed dogs (Konturek et al 1993).…”

Section: No and Pancreatic Acinar Cell Functionmentioning

confidence: 99%

Free radicals and the pancreatic acinar cells: role in physiology and pathology

Chvanov

Petersen

Tepikin

2005

Phil. Trans. R. Soc. B

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Reactive oxygen and nitrogen species (ROS and RNS) play an important role in signal transduction and cell injury processes. Nitric oxide synthase (NOS)-the key enzyme producing nitric oxide (NO)-is found in neuronal structures, vascular endothelium and, possibly, in acinar and ductal epithelial cells in the pancreas. NO is known to regulate cell homeostasis, and its effects on the acinar cells are reviewed here. ROS are implicated in the early events within the acinar cells, leading to the development of acute pancreatitis. The available data on ROS/RNS involvement in the apoptotic and necrotic death of pancreatic acinar cells will be discussed.

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Pancreatic Development

Eisses¹,

Husain²

2021

Pediatric Gastrointestinal and Liver Disease

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Differential Roles of Endogenous Nitric Oxide on Neural Regulation of Basal Exocrine Pancreatic Secretion in Intact and Denervated Pancreas

Cited by 6 publications

References 26 publications

The islet-acinar axis of the pancreas: more than just insulin

The islet-acinar axis of the pancreas: more than just insulin

Free radicals and the pancreatic acinar cells: role in physiology and pathology

Pancreatic Development

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