2010
DOI: 10.4161/cc.9.22.13680
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Differential role of CD133 and CXCR4 in renal cell carcinoma

Abstract: The chemokine receptor CXCR4 and CD133, putative stem cell markers, were previously described in renal cancer (RCC). To evaluate the biological and prognostic role of CD133 and CXCR4 in RCC the expression was evaluated through qPCR and immunoblotting in human renal cancer cell lines (786-O, A498, ACHN, CAKI-1, SN12C, TK10, UO31) and patients biopsies. Renal cancer cells and surgical biopsies expressed functional CXCR4 while CD133 was not detectable. CXCR4 and CD133 expression was then evaluated in 240 renal ca… Show more

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Cited by 63 publications
(61 citation statements)
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“…13,14 Distinct immunostaining pattern of CXCR4 in cytomembrane and/or nucleus is associated with high tumor stage of liver carcinoma and metastasis of ranal cancer. 15,16 In the light of this report our results indicate that high expression of CXCR4 may be correlated with symptomatic and advanced stages of disease and suggesting their definitive role in prognosis of the disease.…”
Section: Discussionsupporting
confidence: 49%
“…13,14 Distinct immunostaining pattern of CXCR4 in cytomembrane and/or nucleus is associated with high tumor stage of liver carcinoma and metastasis of ranal cancer. 15,16 In the light of this report our results indicate that high expression of CXCR4 may be correlated with symptomatic and advanced stages of disease and suggesting their definitive role in prognosis of the disease.…”
Section: Discussionsupporting
confidence: 49%
“…Interestingly, high expression of MMP9 in primary RCC has been demonstrated to be associated with poor prognosis of RCC patients [50]. The properties of CXCR4 þ CSCs also seem to be relevant in RCC patients, since high levels of CXCR4 mRNA or higher content of CXCR4 þ cells were associated with a poor prognosis ( [36,51] and this work). Interestingly, only M0 patients with high CXCR4 mRNA content in their primary tumors, indicating a higher number of CSCs, were more likely to succumb to metastasis, accompanied by a shorter survival time.…”
Section: Discussionmentioning
confidence: 55%
“…For example, chemokine receptor CXCR4 was reported to be 2.01-fold upregulated in the Caki-1 cell line; this was previously reported as a cancer stem cell marker, and CXCR4-positive cells exhibit great resistance to tyrosine kinase inhibitors (27,42,47). In addition, CXCR4 expression has significant prognostic value and therapeutic importance in RCC patients (13). IL-6 expression, meanwhile, was 19.88-fold upregulated in the Caki-1 cell line.…”
Section: Discussionmentioning
confidence: 82%