Differential retinal angiogenic response to sustained intravitreal release of VEGF and bFGF in different pigmented rabbit breeds

Erb, Melanie H.; Sioulis, Christos; Kuppermann, B. D.; Osann, Kathryn; Wong, Carolyn F.

doi:10.1076/ceyr.24.4.245.8412

Cited by 8 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, hemorrhage from the new vessels and even total traction retinal detachment were also observed. Moreover, differential retinal angiogenic response to VEGF/bFGF was reported in different rabbit strains, where Dutch belt rabbits are more susceptible than the NZW/Black satin cross rabbit [ 215 ].…”

Section: Animal Modelsmentioning

confidence: 99%

Animal Models of Diabetic Retinopathy: Summary and Comparison

Lai

2013

Journal of Diabetes Research

174

176

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure to hyperglycemia and is a major cause of blindness worldwide. Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). In this review, we summarize the existing protocols to induce diabetes using STZ. We also describe and compare the pathological presentations, in both morphological and functional aspects, of the currently available DR animal models. The advantages and disadvantages of using different animals, ranging from zebrafish, rodents to other higher-order mammals, are also discussed. Until now, there is no single model that displays all the clinical features of DR as seen in human. Yet, with the understanding of the pathological findings in these animal models, researchers can select the most suitable models for mechanistic studies or drug screening.

show abstract

Section: Animal Modelsmentioning

confidence: 99%

Animal Models of Diabetic Retinopathy: Summary and Comparison

Lai

2013

Journal of Diabetes Research

174

176

View full text Add to dashboard Cite

show abstract

“…In addition to these well-known factors, a number of novel angiogenic proteins have recently been described. [1][2][3][4][5] Leptin, an antiobesity hormone, is a 167 aminoacid protein synthesized in the pituitary gland, adipose tissue, and fibroblasts in the setting of high intracellular triglycerides. Serum leptin concentrations are proportional to the body's adipose mass.…”

Section: Introductionmentioning

confidence: 99%

Vitreous leptin levels in retinal disease

Maberley

Cui

Matsubara

2005

Eye

View full text Add to dashboard Cite

Background/aims The purpose of this study was to investigate the relationship between vitreous leptin levels and retinal diseases. Methods Levels of vitreous leptin were evaluated in proliferative diabetic retinopathy (PDR) and a variety of other retinopathies including: macular disease, neovascular maculopathies, primary retinal detachments, and vascular occlusive disease. Results In patients with PDR (N ¼ 7), the average vitreous level of leptin (37.4 ng/ml) was significantly higher than that in patients with PVR (o1.0 ng/ml, Po0.05). Vitreous leptin level in patients with PVR or macular disease (N ¼ 18), with or without diabetes, was not significantly different from the control subjects who had retinal detachment only (N ¼ 7). Conclusion The results show that the leptin level in vitreous taps is elevated in PDR. We suggest that leptin plays an active role in PDR.

show abstract

“…We initially reported strain-specific differences in responsiveness to these growth factors in mice (1,2). Differential angiogenic responsiveness among strains has been confirmed in additional species and anatomical locations with FGF2 and VEGF (3,4). Earlier we mapped the location of VEGF response loci in BXD recombinant inbred mice (1).…”

mentioning

confidence: 99%

Genetic loci that control the angiogenic response to basic response to basic fibroblast growth factor

et al. 2004

View full text Add to dashboard Cite

Angiogenesis is controlled by a balance between stimulatory growth factors and endogenous inhibitors. We propose that the balance of stimulators and inhibitors, as well as the general sensitivity of the endothelium to these factors, varies from individual to individual. Indeed, we have found that individual mouse strains have dramatically different responses to growth factor-induced neovascularization. Quantitative trait loci (QTLs), which influence the extent of angiogenesis induced by vascular endothelial growth factor (VEGF), were previously identified by our laboratory. Since genetic susceptibility may vary according to the angiogenic stimulator, we have undertaken a similar mapping approach to identify QTLs that influence basic fibroblast growth factor (FGF2) induced neovascularization in the BXD series of recombinant inbred mouse strains. Composite and multiple interval mapping identified areas of chromosomes 4, 13, 15, and 18. These new angiogenesis QTLs, named AngFq1 through AngFq4 (for angiogenesis due to FGF2), are different from previously identified VEGF QTLs. The mapped regions contain several genes involved in the angiogenic process including matrix metalloproteinase 16, eph receptor A7, angiopoetin 1, endothelial lipase, and autotaxin. Differences in these regions may influence individual susceptibility to angiogenesis related diseases such as cancer, macular degeneration, atherosclerosis, and arthritis.

show abstract

Differential retinal angiogenic response to sustained intravitreal release of VEGF and bFGF in different pigmented rabbit breeds

Cited by 8 publications

References 13 publications

Animal Models of Diabetic Retinopathy: Summary and Comparison

Animal Models of Diabetic Retinopathy: Summary and Comparison

Vitreous leptin levels in retinal disease

Genetic loci that control the angiogenic response to basic response to basic fibroblast growth factor

Contact Info

Product

Resources

About