2002
DOI: 10.1076/ceyr.24.4.245.8412
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Differential retinal angiogenic response to sustained intravitreal release of VEGF and bFGF in different pigmented rabbit breeds

Abstract: These studies indicate that two different breeds of pigmented rabbits exhibit different angiogenic responses to the same amount of both VEGF and bFGF. Florid retinal NV leading to hemorrhage, fibrovascular membrane formation, and traction retinal detachment occurred in the Dutch belt rabbits while tortuosity and dilatation of existing blood vessels with subsequent regression occurred in the NZW/Black satin cross animals. Such differences in the angio-genic response may be due to differences in the genetic back… Show more

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Cited by 8 publications
(6 citation statements)
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“…In addition, hemorrhage from the new vessels and even total traction retinal detachment were also observed. Moreover, differential retinal angiogenic response to VEGF/bFGF was reported in different rabbit strains, where Dutch belt rabbits are more susceptible than the NZW/Black satin cross rabbit [ 215 ].…”
Section: Animal Modelsmentioning
confidence: 99%
“…In addition, hemorrhage from the new vessels and even total traction retinal detachment were also observed. Moreover, differential retinal angiogenic response to VEGF/bFGF was reported in different rabbit strains, where Dutch belt rabbits are more susceptible than the NZW/Black satin cross rabbit [ 215 ].…”
Section: Animal Modelsmentioning
confidence: 99%
“…In addition to these well-known factors, a number of novel angiogenic proteins have recently been described. [1][2][3][4][5] Leptin, an antiobesity hormone, is a 167 aminoacid protein synthesized in the pituitary gland, adipose tissue, and fibroblasts in the setting of high intracellular triglycerides. Serum leptin concentrations are proportional to the body's adipose mass.…”
Section: Introductionmentioning
confidence: 99%
“…We initially reported strain-specific differences in responsiveness to these growth factors in mice (1,2). Differential angiogenic responsiveness among strains has been confirmed in additional species and anatomical locations with FGF2 and VEGF (3,4). Earlier we mapped the location of VEGF response loci in BXD recombinant inbred mice (1).…”
mentioning
confidence: 99%