Differential responses to mental stress in high and low anxious normal humans assessed by frontal midline theta activity

Mizuki, Yasushi; Kajimura, Naofumi; Shi, Kai; Suetsugi, Masatomo; Ushijima, Itsuko; Yamada, Masakazu

doi:10.1016/0167-8760(92)90008-y

Cited by 52 publications

(23 citation statements)

References 25 publications

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“…Tryptophan depletion causes a depletion of 5-HT levels in the entire brain (Phillips et al, 2000). Buspirone treatment, at doses similar to those used in the present study, reduces plasma 5-HT and its metabolite concentrations (Mizuki et al, 1994). An acute dose of buspirone in the rat significantly reduces 5-HT synthesis in the brain (Okazawa et al, 1999) and completely inhibits dorsal raphe nucleus firing (VanderMaelen et al, 1986), most likely by its action at presynaptic 5-HT 1A receptors.…”

Section: Discussionmentioning

confidence: 50%

“…This dose of estradiol produces physiological concentrations of 17b-estradiol (Fink and Christensen, 1981;Furuhjelm et al, 1984). The dose of buspirone has been shown to exert pharmacodynamic effects in humans (Hellewell et al, 1999;Mizuki et al, 1994). Time of testing after drug administration was chosen to coincide with peak pharmacokinetic effects of both buspirone (ie 60-90 min) and estradiol (ie 4-6 h).…”

Section: Methodsmentioning

confidence: 99%

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Estrogen Prevents 5-HT1A Receptor-Induced Disruptions of Prepulse Inhibition in Healthy Women

Gogos

Nathan

Guille

et al. 2005

Neuropsychopharmacol

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The sex steroid hormone, estrogen, has been proposed to be protective against schizophrenia. This study examined the effects of estrogen treatment on modulation of prepulse inhibition (PPI) by the serotonin-1A (5-HT 1A ) receptor partial agonist, buspirone. PPI is a model of sensorimotor gating, which is deficient in schizophrenia and other mental illnesses. A total of 11 healthy women were tested following four acute treatment conditions: placebo, buspirone (Buspar; 5 mg), estradiol (Estrofem; 2 mg), and combined buspirone and estradiol. Electromyogram activity was measured across three interstimulus intervals (ISI): 30, 60, and 120 ms. There was no significant effect of either drug treatment on startle amplitude or habituation. At 120 ms ISI, buspirone caused a significant disruption of PPI and pretreatment with estrogen prevented this disruption. Estrogen treatment, administered in the appropriate experimental conditions, prevented PPI deficits induced by 5-HT 1A receptor activation and may therefore also play a protective role in sensorimotor gating deficits in schizophrenia.

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Section: Discussionmentioning

confidence: 50%

Section: Methodsmentioning

confidence: 99%

Estrogen Prevents 5-HT1A Receptor-Induced Disruptions of Prepulse Inhibition in Healthy Women

Gogos

Nathan

Guille

et al. 2005

Neuropsychopharmacol

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“…Specifically, Fm is more marked in subjects who are more extroverted, less neurotic and less anxious, while subjects who are more introverted, more neurotic and more anxious show either a smaller amount of Fm or none at all. Using centrally acting drugs such as diazepam, amobarbital, methylphenidate, yohimbine, clonidine, sulpiride, bromocriptine, clomipramine, buspirone and placebo in normal humans, we also detected a significant correlation between the appearance of Fm and a decrease in state anxiety for all drugs [3][4][5][6][7][8]. Anxiety is a major problem in the field of clinical psychiatry, because most psychiatric diseases are accompanied by various types and levels of anxiety [9].…”

Section: Introductionmentioning

confidence: 67%

Appearance of Frontal Midline Theta Activity in Patients with Generalized Anxiety Disorder

et al. 2000

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The appearance of frontal midline theta activity (Fmθ), recognized as distinct EEG theta rhythm in the frontal midline area during performance of a mental task, reflects feelings of relief from anxiety in humans. In the present study, EEGs were recorded, and the Hamilton Rating Scale for Anxiety and the state anxiety scale of Spielberger’s State-Trait Anxiety Inventory were evaluated once a week in 28 patients with generalized anxiety disorder. The Taylor Manifest Anxiety Scale and the trait anxiety scale of Spielberger’s State-Trait Anxiety Inventory were used to assess anxiety before and after the tests. The present results suggest that the appearance of Fmθ might be closely related to an improvement in the anxiety symptoms associated with generalized anxiety disorder.

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“…Theta oscillations are seen in human electroencephalograms, and, although the precise anatomical origins of these oscillations are still debated, they are thought to arise from corticolimbic interactions, perhaps driven by hippocampal theta (Basar et al, 2001;Kahana et al, 2001;Cantero et al, 2003). Conflicting reports differ on the relationship between theta in human electroencephalograms and anxiety traits or disorders (Mizuki et al, 1992(Mizuki et al, , 1994SaletuZyhlarz et al, 1997;Romano-Torres et al, 2002;Aftanas et al, 2003;Sachs et al, 2004). A drawback to many of these studies is that EEG recordings were obtained at rest or during cognitive tasks; the results reported here would suggest that symptom provocation studies might be an effective way to look for disorder-related increases in theta power in humans with anxiety disorders.…”

Section: Resultsmentioning

confidence: 97%

State-Dependent Alterations in Hippocampal Oscillations in Serotonin 1A Receptor-Deficient Mice

Gordon

Lacefield²,

Kentros³

et al. 2005

J. Neurosci.

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Mice lacking the serotonin 1A receptor (5-HT 1A R) show increased levels of anxiety-related behavior across multiple tests and background strains. Tissue-specific rescue experiments, lesion studies, and neurophysiological findings all point toward the hippocampus as a potential mediator of the phenotype. Serotonin, acting through 5-HT 1A Rs, can suppress hippocampal theta-frequency oscillations, suggesting that theta oscillations might be increased in the knock-outs. To test this hypothesis, local field potential recordings were obtained from the hippocampus of awake, behaving knock-outs and wild-type littermates. The magnitude of theta oscillations was increased in the knock-outs, specifically in the anxiety-provoking elevated plus maze and not in a familiar environment or during rapid eye movement sleep. Theta power correlated with the fraction of time spent in the open arms, an anxiety-related behavioral variable. These results suggest a possible role for the hippocampus, and theta oscillations in particular, in the expression of anxiety in 5-HT 1A Rdeficient mice.

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Differential responses to mental stress in high and low anxious normal humans assessed by frontal midline theta activity

Cited by 52 publications

References 25 publications

Estrogen Prevents 5-HT1A Receptor-Induced Disruptions of Prepulse Inhibition in Healthy Women

Estrogen Prevents 5-HT1A Receptor-Induced Disruptions of Prepulse Inhibition in Healthy Women

Appearance of Frontal Midline Theta Activity in Patients with Generalized Anxiety Disorder

State-Dependent Alterations in Hippocampal Oscillations in Serotonin 1A Receptor-Deficient Mice

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