Differential responses of the hypothalamo-pituitary-adrenocortical axis to acute restraint stress in Hatano high- and low-avoidance rats

Asai, Sayaka; Ohta, Ryo; Shirota, Mariko; Watanabe, Gen; Taya, Kazuyoshi

doi:10.1677/joe.0.1810515

Cited by 28 publications

(31 citation statements)

References 24 publications

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“…In accordance with the present results suggesting that direct adrenal effects of PRL may be important for steroidogenesis in the response to stress, there are observations from animal studies in which glucocorticoid levels can remain elevated during stress, despite de- clining CRH and/or ACTH concentrations [20,21,[40][41][42]. Previous studies have demonstrated that exercise stress induced an increase in circulating PRL in humans [43][44][45][46][47][48].…”

Section: Discussionsupporting

confidence: 91%

Physiological Roles of Prolactin in the Adrenocortical Response to Acute Restraint Stress

et al. 2007

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Abstract. The present study characterized the different hormonal responses to stress in the endocrine milieu with different circulating levels of prolactin (PRL) and examined the direct effects of PRL on adrenal steroidogenic responses to adrenocorticotropic hormone (ACTH) using experimentally induced hyperprolactinemia and hypoprolactinemia male rat models. Hyperprolactinemia was induced by transplantation of two adult female rat anterior pituitary glands under the kidney capsule for 2 weeks, and hypoprolactinemia was induced by daily subcutaneous injection of 2-Bromo-alphaErgocryptine (CB-154) for 2 weeks. Under stress conditions, the peak levels of ACTH were significantly higher in hypoprolactinemia than normal rats. Meanwhile, the peak levels of corticosterone and progesterone were significantly higher in hyperprolactinemia than in normal and hypoprolactinemia stressed rats. Results of in vitro experiments showed that adrenocortical cells in hyperprolactinemia exhibited higher basal levels of corticosterone and progesterone rats than normal and hypoprolactinemia rats. The stimulatory effect of ACTH on corticosterone and progesterone release was higher in hyperprolactinemia than hypoprolactinemia rats. In addition, PRL increased the stimulatory effect of ACTHinduced corticosterone secretion in all rat models. These results suggest that hypoprolactinemia and hyperprolactinemia rats exhibit marked differences in the response of their hypothalamic-pituitary-adrenal (HPA) axis during acute restrain stress. Additionally, these studies emphasize that the adrenal cortex might be more sensitive to ACTH stimulation in endocrine milieu with high levels of PRL resulting in high corticosterone and progesterone release.

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Section: Discussionsupporting

confidence: 91%

Physiological Roles of Prolactin in the Adrenocortical Response to Acute Restraint Stress

et al. 2007

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“…Selective breeding based on 'high/ low-avoidance' performance was suggested to relate to differences in 'emotional' factors (state/trait anxiety) that influenced performance (Brush, 2003). For example, the 'high-avoidance' and 'low-avoidance' Hatano rat strains did not differ in locomotion activity (Ohta et al, 1999), but the 'low-avoidance' strain had a higher adrenocorticotropin (ACTH)-induced adrenal CORT release response than the 'high-avoidance' strain (Asai et al, 2004). The increased rates of escape failure in the shuttle box that we found among adult juvenilestressed rats (Figure 3c) may also imply an emotional disruption.…”

Section: Exposure To Stress During Juvenility Alters Emotional Responmentioning

confidence: 99%

Exposure to Stressors during Juvenility Disrupts Development-Related Alterations in the PSA-NCAM to NCAM Expression Ratio: Potential Relevance for Mood and Anxiety Disorders

Tsoory

Guterman

Richter‐Levin

2007

Neuropsychopharmacol

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Childhood trauma is associated with higher rates of both mood and anxiety disorders in adulthood. The exposure of rats to stressors during juvenility has comparable effects, and was suggested as a model of induced predisposition for these disorders. The neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM are critically involved in neural development, activity-dependent synaptic plasticity, and learning processes. We examined the effects of exposure to stressors during juvenility on coping with stressors in adulthood and on NCAM and PSA-NCAM expression within the rat limbic system both soon after the exposure and in adulthood. Exposure to stressors during juvenility reduced novel-setting exploration and impaired two-way shuttle avoidance learning in adulthood. Among naive rats, a development-related decrease of about 50% was evident in the PSA-NCAM to NCAM expression ratio in the basolateral amygdala, in the CA1 and dentate gyrus regions of the hippocampus, and in the entorhinal cortex. In juvenile-stressed rats, we found no such decrease, but rather an increase in the polysialylation of NCAM (B50%), evident soon after the exposure to juvenile stress and also in adulthood. Our results suggest that exposure to stressors during juvenility alters the maturation of the limbic system, and potentially underlies the predisposition to exhibit stress-related symptoms in adulthood.

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“…Moreover, our previous reports demonstrated that Haa and Laa have strain differences in locomotor activity and endocrine stress response [2-4, 21, 28, 31]. in brief, Haa shows high activity in running wheel cage [28], high adrenocorticotropin (actH) and low prolactin in plasma during restraint stress compared with Laa [2,4]. but emotional characteristics of Hatano rats have not been investigated yet.…”

Section: Introductionmentioning

confidence: 99%

Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

et al. 2012

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Our prime objective was to establish an optimal model animal for studying avoidance learning and memory in rodents. The two-way rat inbred strains of Hatano high-(HAA) and lowavoidance (LAA) animals were originally selected and bred in accordance with their high or low performance respectively in the shuttle-box active avoidance task. Previous studies demonstrated that they have clear strain differences in endocrine stress response, which is related to acquisition of aversive learning and emotional reactivity. To evaluate the effect of selection by the shuttle-box task on avoidance performance and emotional reactivity, male Hatano rats underwent passive avoidance, open field and elevated plus maze tests. The present results show that the avoidance performance in the passive task was significantly greater in HAA rats than in LAA rats. Furthermore, HAA rats showed high anxiety-like behaviors compared with LAA rats in open field and elevated plus maze tests. Taken together, this study demonstrated that 1) selection and breeding of Hatano HAA and LAA strain rats by shuttle-box task had been properly carried out with the criterion of high and low avoidance performance respectively and that 2) HAA rats were predisposed to high anxiety compared with LAA rats. These results indicated that Hatano HAA and LAA rats can be useful models for studying avoidance learning and memory.

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Differential responses of the hypothalamo-pituitary-adrenocortical axis to acute restraint stress in Hatano high- and low-avoidance rats

Cited by 28 publications

References 24 publications

Physiological Roles of Prolactin in the Adrenocortical Response to Acute Restraint Stress

Physiological Roles of Prolactin in the Adrenocortical Response to Acute Restraint Stress

Exposure to Stressors during Juvenility Disrupts Development-Related Alterations in the PSA-NCAM to NCAM Expression Ratio: Potential Relevance for Mood and Anxiety Disorders

Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

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