Differential replication of male and female X-chromosomes in Drosophila

Berendes, H. D.

doi:10.1007/bf00331896

Cited by 63 publications

(26 citation statements)

References 18 publications

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“…8). The sex-specific early replication of the X had first been noted >50 yr ago using tritium-labeled metaphase chromosome spreads (Berendes 1966;Meer 1976) and more recently was rediscovered by our group and others (Schwaiger et al 2009) in the genomic era.…”

Section: Male-specific Early Replication Of the X Chromosomementioning

confidence: 91%

“…These results suggest that the replication program for static early and late replicating domains is primarily established by origin selection (ORC binding) and that origin activation modulates the plasticity of the DNA replication program between cell lines. Finally, we show that the X chromosome and male-specific patterns of early replication (Berendes 1966;Lakhotia and Mukherjee 1970;Meer 1976;Schwaiger et al 2009) are dependent on the dosage compensation complex (DCC) and that a single histone modification is sufficient to alter the replication timing of an entire chromosome.…”

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confidence: 98%

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DNA replication and transcription programs respond to the same chromatin cues

et al. 2014

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DNA replication is a dynamic process that occurs in a temporal order along each of the chromosomes. A consequence of the temporally coordinated activation of replication origins is the establishment of broad domains (>100 kb) that replicate either early or late in S phase. This partitioning of the genome into early and late replication domains is important for maintaining genome stability, gene dosage, and epigenetic inheritance; however, the molecular mechanisms that define and establish these domains are poorly understood. The modENCODE Project provided an opportunity to investigate the chromatin features that define the Drosophila replication timing program in multiple cell lines. The majority of early and late replicating domains in the Drosophila genome were static across all cell lines; however, a small subset of domains was dynamic and exhibited differences in replication timing between the cell lines. Both origin selection and activation contribute to defining the DNA replication program. Our results suggest that static early and late replicating domains were defined at the level of origin selection (ORC binding) and likely mediated by chromatin accessibility. In contrast, dynamic domains exhibited low ORC densities in both cell types, suggesting that origin activation and not origin selection governs the plasticity of the DNA replication program. Finally, we show that the male-specific early replication of the X chromosome is dependent on the dosage compensation complex (DCC), suggesting that the transcription and replication programs respond to the same chromatin cues. Specifically, MOF-mediated hyperacetylation of H4K16 on the X chromosome promotes both the up-regulation of male-specific transcription and origin activation.

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Section: Male-specific Early Replication Of the X Chromosomementioning

confidence: 91%

mentioning

confidence: 98%

DNA replication and transcription programs respond to the same chromatin cues

et al. 2014

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“…This necessitates the need to increase gene expression from the single X chromosome, a process termed dosage compensation. Early experiments analyzing the replication patterns of Drosophila salivary gland polytene chromosomes by tritium labeling revealed that the X chromosomes of males completed replication earlier than the female X chromosomes, whereas autosomes replicated with similar kinetics (Berendes, 1966). Consistent with these observations, analysis of the dosage-compensated X chromosome from a male-derived cell line revealed that the male X replicates almost entirely in early S phase, whereas the X chromosomes from a female-derived cell line have early and late replication profiles similar to those of autosomes (Schwaiger et al, 2009).…”

Section: Comparative Genomic Hybridization (Acghmentioning

confidence: 99%

Regulation of DNA replication during development

2012

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SummaryAs development unfolds, DNA replication is not only coordinated with cell proliferation, but is regulated uniquely in specific cell types and organs. This differential regulation of DNA synthesis requires crosstalk between DNA replication and differentiation. This dynamic aspect of DNA replication is highlighted by the finding that the distribution of replication origins varies between differentiated cell types and changes with differentiation. Moreover, differential DNA replication in some cell types can lead to increases or decreases in gene copy number along chromosomes. This review highlights the recent advances and technologies that have provided us with new insights into the developmental regulation of DNA replication.

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“…(Keyl and Pelling, 1963;Gabrusewycz-Garcia, 1964;Fujita, 1965;Plaut et al, 1966;Berendes, 1966;Nash and Bell, 1968;Rodman, 1968). There is not general agreement, however, concerning the pattern of initiation of DNA synthesis in these chromosomes.…”

Section: Dna Synthesismentioning

confidence: 99%

“…Berendes (1966) has proposed that certain bands in the male polytene X-chromosomes of Drosophila melanogaster replicate faster than their homologues in female X-chromosomes. However, the sequence of synthesis is thought to be the same.…”

Section: Dna Synthesismentioning

confidence: 99%

CHROMOSOMAL DNA SYNTHESIS IN DROSOPHILA MELANOGASTER

Howard

Plaut

1968

The Journal of Cell Biology

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Analysis of labeling patterns in three chromosome segments of Drosophila rnelanogaster has shown that the replicative activity within chromosomes is temporally ordered. Moreover, specific labeling patterns on one chromosome occur with specific patterns on another chromosome with a very high degree of correlation. This circumstance leads to the conclusion that DNA synthesis among all the regions in the three chromosome segments studied is coordinated. The various labeling patterns observed in any one chromosome and the combinations of labeling patterns observed in all three chromosome segments can be arranged in ordered arrays, if one assumes that the DNA synthesis in each chromosome region will go to completion without stopping once it has started. Such arrays can serve as models for the temporal order of DNA synthesis among chromosome regions. They predict that in any one chromosome DNA rcplication begins and ends at very few loci and that synthesis at a larger number of points occurs at an intermediate time.

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Differential replication of male and female X-chromosomes in Drosophila

Cited by 63 publications

References 18 publications

DNA replication and transcription programs respond to the same chromatin cues

DNA replication and transcription programs respond to the same chromatin cues

Regulation of DNA replication during development

CHROMOSOMAL DNA SYNTHESIS IN DROSOPHILA MELANOGASTER

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