Differential relationships of impulsivity or antisocial symptoms on P50, N100, or P200 auditory sensory gating in controls and antisocial personality disorder

Abstract

Limited information is available on the relationship between antisocial personality disorder (ASPD) and early filtering, or gating, of information, even though this could contribute to the repeatedly reported impairment in ASPD of higher-order information processing. In order to investigate early filtering in ASPD, we compared electrophysiological measures of auditory sensory gating assessed by the paired-click paradigm in males with ASPD (n = 37) to healthy controls (n = 28). Stimulus encoding was measured by P50, N100, and P200 auditory evoked potentials; auditory sensory gating (ASG) was measured by a reduction in amplitude of evoked potentials following click repetition. Effects were studied of co-existing past alcohol or drug use disorders, ASPD symptom counts, and trait impulsivity. Controls and ASPD did not differ in P50, N100, or P200 amplitude or ASG. Past alcohol or drug use disorders had no effect. In controls, impulsivity related to improved P50 and P200 gating. In ASPD, P50 or N100 gating was impaired with more symptoms or increased impulsivity, respectively, suggesting impaired early filtering of irrelevant information. In controls the relationship between P50 and P200 gating and impulsivity was reversed, suggesting better gating with higher impulsivity scores. This could reflect different roles of ASG in behavioral regulation in controls versus ASPD.

The association between psychosis proneness and sensory gating in cocaine-dependent patients and healthy controls

“…We based this hypothesis on the assumption that the different MLAER components reflect different, albeit related, underlying mechanisms and functions (Boutros et al, 2004a; Brockhaus-Dumke et al, 2008; Crowley and Colrain, 2004; Lijffijt et al, 2012; Lijffijt et al, 2009). Sensory gating is a multistage process, and the different MLAER gating indices are not redundant measures of sensory gating mechanisms.…”

“…Sensory gating is a multistage process, and the different MLAER gating indices are not redundant measures of sensory gating mechanisms. Indeed, P50 is thought to reflect pre-attentional processes, N100 is associated with attentional triggering, particularly to irrelevant information, and P200 is associated with orienting and allocation of attention (Lijffijt et al, 2012; Náátánen, 1992). We found that the correlates of P50 gating were not the same as the correlates of N100 and P200 gating.…”

Learning processes underlying avoidance of negative outcomes

“…Once the stimulus is detected, attention may (or may not) be allocated to it, and this process has been related to P200 amplitude. Furthermore, impulsivity (Lijffijt et al, ) as well as expression style of angry feelings (measured by the Anger Expression Inventory, Stewart et al, ), positively correlated with N100 amplitude. Moreover, findings have shown that frontocentral P200 was larger for wins (indicated by positive feedback), compared to losses (indicated by negative feedback).…”

A Proof-of-Mechanism Study to Test Effects of the NMDA Receptor Antagonist Lanicemine on Behavioral Sensitization in Individuals With Symptoms of PTSD

“…P50 auditory sensory gating measures P50 amplitude suppression following presentation of the same auditory stimulus in short temporal proximity, reflecting pre-attentional information filtering (95)(96)(97)(98). P50 gating is impaired in PTSD compared to trauma controls (99), and after acute stress in healthy individuals (100,101).…”