Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia

Berman, Ileana; Viegner, Barbara; Merson, Amalia; Allan, Edward; Pappas, Demetra M.; Green, Alan I.

doi:10.1016/s0920-9964(96)00098-9

Cited by 189 publications

(105 citation statements)

References 34 publications

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“…None of the schizotypy measures was associated with performance on discrimination learning before the target shift. These results are consistent with past evidence that shift learning, as assessed by the WCST, is primarily related to the severity of negative symptoms in schizophrenic patients (e.g., Berman et al, 1997;Butler et al, 1992;Voruganti et al, 1997), and negative schizotypy in non-clinical participants (Daneluzzo et al, 1998;Laurent et al, 2001;Raine et al, 1992;Suhr & Spitznagel, 2001).…”

Section: Discussionsupporting

confidence: 92%

Dimensional approaches to experimental psychopathology of schizophrenia: shift learning and report of psychotic-like experiences in college students

Tsakanikos

Reed

2005

Journal of Behavior Therapy and Experimental Psychiatry

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Adopting a dimensional approach to experimental psychopathology, and taking into account inconsistencies in the previous literature, we examined whether reports of psychoticlike experiences in undergraduate students were associated with shift-learning deficits, akin to those seen in schizophrenia. The participants (N ¼ 72) were tested on a new compound stimulus discrimination task before and after a target shift, and were administered a multidimensional schizotypy inventory (O-LIFE). Performance impairment following a target shift was associated with the negative (introvertive anhedonia) and the impulsive (impulsive nonconformity) dimension of schizotypy, but not with the positive (unusual experiences), nor the disorganised (cognitive disorganisation) dimension. None of the schizotypy measures were associated with performance on discrimination learning before the target shift. The obtained results are in line with past evidence that shift learning is associated with the severity of the negative symptomatology of schizophrenia. The possibility that psychotic-like features may

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Section: Discussionsupporting

confidence: 92%

Dimensional approaches to experimental psychopathology of schizophrenia: shift learning and report of psychotic-like experiences in college students

Tsakanikos

Reed

2005

Journal of Behavior Therapy and Experimental Psychiatry

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“…Second, impaired cognition as measured in various psychological and neuropsychological test procedures, is now viewed as central to the early manifestations of schizophrenia and critically related to functional outcomes. The impaired cognitive pathology is not significantly associated with the symptom domains (Gold and Harvey, 1993;Berman et al, 1997;Harvey et al, 2006;Cohen et al, 2007) but is comprised of seven independent areas of impairment, which were identified by the academic/pharmaceutical/governmental MATRICS initiative (Table 1). The specificity of these concepts should facilitate developing animal and human experimental models.…”

Section: A Paradigm Shift To Facilitate Drug Discoverymentioning

confidence: 99%

The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities

Carpenter

Koenig

2007

Neuropsychopharmacol

185

128

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“…Similarly, dysfunctional neural responses to errors in other clinical groups have also shown to relate to their general symptom profile. For example, patients with schizophrenia have diminished levels of ACC activity in response to errors (Kerns et al, 2005;Mathalon et al, 2002), with the level of dysfunction relating to the severity of disorganization symptoms (ie, formal thought disorder, inappropriate affect, and bizarre behavior) (Bates et al, 2002;Berman et al, 1997;Frith and Done, 1989;Liddle et al, 1992). Alzheimer's disease has also been associated with a progressive deterioration in error awareness (Cahn et al, 1997;Neils-Strunjas et al, 1998) and the neural response to errors (Mathalon et al, 2003).…”

Section: Post-error Adaptationmentioning

confidence: 99%

Post-Error Behavior in Active Cocaine Users: Poor Awareness of Errors in the Presence of Intact Performance Adjustments

Hester

Simões‐Franklin

Garavan

2007

Neuropsychopharmacol

107

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Active cocaine abusers have a diminished neural response to errors, particularly in the anterior cingulate cortex thought critical to error processing. The inability to detect, or adjust performance following errors has been linked to clinical symptoms including the loss of insight and perseverative behavior. We investigated the cognitive implications of this diminished error-related activity, using response inhibition tasks that required error awareness and performance adaptation. Twenty-one active cocaine users (six female subjects, mean age ¼ 40.3) and 22 non-drug using adults (six female subjects, mean ¼ 39.9) participated. The results indicated that cocaine users consistently demonstrated poorer inhibitory control, a deficit accompanied by reduced awareness of errors. Adaptation of post-error reaction times did not differ between groups, although a different measure of adaptive behavior: exerting inhibitory control on the trial immediately after failing to inhibit, was significantly poorer in the cocaine using sample. In summary, cocaine users demonstrated a diminished capacity for monitoring their behavior, but were able to perform post-error adjustment to processes not already suffering an underlying deficit. These difficulties are consistent with previous reports of cocaine-related hypoactivity in the neural system underlying cognitive control, and highlight the potential for cognitive dysfunction to manifest as behavioral deficits that likely contribute to the maintenance of drug dependence.

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Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia

Cited by 189 publications

References 34 publications

Dimensional approaches to experimental psychopathology of schizophrenia: shift learning and report of psychotic-like experiences in college students

Dimensional approaches to experimental psychopathology of schizophrenia: shift learning and report of psychotic-like experiences in college students

The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities

Post-Error Behavior in Active Cocaine Users: Poor Awareness of Errors in the Presence of Intact Performance Adjustments

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