Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages

Goodman, Adam R.; Levy, David E.; Reis, Luiz F. L.; Vilček, Ján

doi:10.1002/jlb.67.3.387

Cited by 59 publications

(44 citation statements)

References 45 publications

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“…The long pentraxin PTX3 is a soluble pattern recognition receptor produced by diverse cell types in response to primary inflammatory cytokines and microbial products [7][8][9][10][11][12][13] [25][26][27]. The results presented here demonstrate that DC of myelomonocytic origin are the most efficient producers of PTX3 among the cell types considered in the present study.…”

Section: Discussionmentioning

confidence: 82%

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Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells

et al. 2003

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PTX3 is a prototypic of long pentraxin consisting of an N-terminal portion coupled to a Cterminal pentraxin domain, the latter related to short pentraxins (C-reactive protein and serum amyloid P component). PTX3 is a soluble pattern recognition receptor, which plays a non-redundant role in resistance against selected pathogens and in female fertility. The present study was designed to analyze the production of PTX3 by human dendritic cells (DC) and to define the role of different innate immunity receptors in its induction. Human monocyte-derived DC produced copious amounts of PTX3 in response to microbial ligands engaging different members of the Toll-like receptor (TLR) family (TLR1 through TLR6), whereas engagement of the mannose receptor had no substantial effect. DC were better producers of PTX3 than monocytes and macrophages. Freshly isolated peripheral blood myeloid DC produced PTX3 in response to diverse microbial stimuli. In contrast, plasmacytoid DC exposed to influenza virus or to CpG oligodeoxynucleotides engaging TLR9, did not produce PTX3. PTX3-expressing DC were present in inflammatory lymph nodes from HIVinfected patients. These results suggest that DC of myelomonocytic origin are a major source of PTX3, a molecule which facilitates pathogen recognition and subsequent activation of innate and adaptive immunity.

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Section: Discussionmentioning

confidence: 82%

“…Previous studies had shown that mononuclear phagocytes are major producers of the prototypic long pentraxin PTX3 [25][26][27]. Here we wanted to examine how differentiation to DC affected their capacity to produce PTX3.…”

Section: Production Of Ptx3 By Modcmentioning

confidence: 99%

Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells

et al. 2003

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“…TNF␣ and IL-1, two major mediators of inflammation, have been reported to induce the transcriptional activation of the PTX3 gene (19,21,46). LPS, which raises PTX3 plasma levels after injection in mice, shows a direct effect by activating the PTX3 gene.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the long pentraxin PTX3 as a TNFα-induced secreted protein of adipose cells

Abderrahim-Ferkoune

Bézy

Chiellini

et al. 2003

Journal of Lipid Research

127

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Exposure of preadipocytes to long-chain fatty acids induces the expression of several markers of adipocyte differentiation. In an attempt to identify novel genes and proteins that are regulated by fatty acids in preadipocytes, we performed a substractive hybridization screening and identified PTX3, a protein of the pentraxin family. PTX3 mRNA expression is transient during adipocyte differentiation of clonal cell lines and is absent in fully differentiated cells. Stable overexpression of PTX3 in preadipocytes has no effect on adipocyte differentiation. In line with this, PTX3 mRNA is expressed in the stromal-vascular fraction of adipose tissue, but not in the adipocyte fraction; however, in 3T3-F442A adipocytes, the PTX3 gene can be reinduced by tumor necrosis factor ␣ (TNF ␣ ) in a dose-dependent manner. This effect is accompanied by PTX3 protein secretion from both 3T3-F442A adipocytes and explants of mouse adipose tissue. PTX3 mRNA levels are found to be higher in adipose tissue of genetically obese mice versus control mice, consistent with their increased TNF ␣ levels. In conclusion, PTX3 appears as a TNF ␣ -induced protein that provides a new link between chronic low-level inflammatory state and obesity. -Abderrahim-Ferkoune, A., O.

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“…8 Expression of various biologically active substances in the GCF in various periodontal diseases has been highlighted and well documented in the literature. Earlier studies have tried to assess the levels of PTX-3 in GCF in healthy periodontal tissue and during orthodontic treatment.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin-3 Levels in Gingival Crevicular Fluid during Canine Retraction with Nickel–Titanium Coil Spring and Active Tieback

Thukral

Mangat²,

Ganguly³

et al. 2017

The Journal of Contemporary Dental Practice

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Aim: Orthodontic treatment is routinely carried out in patients with the purpose of correcting various forms of dental malocclusions. Retraction of the canines can be achieved either individually or along with incisor. Pentraxin-3 (PTX-3) is regarded as the true independent indicator of disease activity. Hence, we undertook the present study to assess and compare the level of PTX-3 in patients undergoing canine retraction with active tieback and Nickel-Titanium (NiTi) coil spring. Materials and methods:The present study included assessment of 25 patients that underwent canine retraction as a part of fixed orthodontic treatment. In the maxillary right and left quadrant, active tieback and NiTi coil spring were used respectively. Gingival crevicular fluid samples were collected 1 hour prior to the commencement of orthodontic canine retraction procedure followed by collection at following time intervals: 1 hour, 1, 7, and 14 days after the start of canine retraction procedure. Enzyme-linked immunosorbent assay kit was used for analysis of the samples as per manufacturer's instructions. All the data were recorded and compiled. All the results were analyzed by Statistical Package for the Social Sciences software. Results Conclusion:In comparison to the active tieback, NiTi coil exhibited faster space closure rate. Clinical significance:In patients undergoing orthodontic treatment, PTX-3 is associated with periodontal remodeling under the effect of orthodontic forces.

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Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages

Cited by 59 publications

References 45 publications

Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells

Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells

Characterization of the long pentraxin PTX3 as a TNFα-induced secreted protein of adipose cells

Pentraxin-3 Levels in Gingival Crevicular Fluid during Canine Retraction with Nickel–Titanium Coil Spring and Active Tieback

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