Differential regulation of right and left ventricular beta-adrenergic receptors in newborn lambs with experimental cyanotic heart disease.

Bernstein, Daniel; Voss, Ellen M.; Huang, Shiew Mei; Doshi, Rajkumar; Crane, Charles M.

doi:10.1172/jci114435

Cited by 29 publications

(18 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 One possible explanation is a higher density of -adrenergic receptors in the LV than in the RV. 9 Interestingly, in the present study, a significant differential response to -adrenergic stimulation was found between LV and RV in both experimental groups and between the normal and volume-loaded RV. Teitel et al 10 reported a limited ability to increase myocardial contractility in the newborn lamb.…”

Section: Discussionsupporting

confidence: 50%

Effects of Pulmonary Insufficiency on Biventricular Function in the Developing Heart of Growing Swine

et al. 2003

View full text Add to dashboard Cite

Background-This study was conducted to determine the effects of chronic pulmonary insufficiency (PI) on right (RV) and left (LV) ventricular function in young growing swine. Methods and Results-Six PI and 5 control animals were studied. PI was induced by transcatheter placement of stents across the pulmonary valve. Indices of systolic function (ejection fraction, cardiac output, and cardiac functional reserve), diastolic function (compliance), and myocardial contractility (the slope of the relationship of end-systolic pressure versus end-systolic volume [E max ] and the slope of the dP/dt max -end-diastolic volume relationship [M dP/dt ]) were assessed within 2 days of intervention and 3 months later. MRI was used to quantify PI and ventricular volumes. Conductance catheter techniques were used to obtain indices of contractility and diastolic compliance from pressure-volume relations at rest and under dobutamine infusion. In the PI group, pulmonary regurgitant fraction was 49.2Ϯ5.9% at 3-month follow-up. RV cardiac functional reserve was limited, diastolic function was preserved, and myocardial contractility was altered (E max ϭ2.6Ϯ0.3 mm Hg/mL for the PI group versus 3.5Ϯ0.4 mm Hg/mL for control; PϽ0.01). LV cardiac functional reserve was limited, ventricular compliance decreased, and myocardial contractility was preserved. Conclusions-In the young developing heart, chronic PI alters biventricular systolic function, RV myocardial contractility, and LV diastolic performance.

show abstract

Section: Discussionsupporting

confidence: 50%

Effects of Pulmonary Insufficiency on Biventricular Function in the Developing Heart of Growing Swine

et al. 2003

View full text Add to dashboard Cite

show abstract

“…However, the results have not been very consistent. Although some investigators have reported a chamber-specific attenuation in the cardiac P-adrenoceptor density (17)(18)(19), others have observed differential regulation (6), no change (22), or even an increase under chronic hypoxic experimental conditions (23). Nonetheless, some of these findings deserve some comment with respect to our present findings.…”

Section: Discussioncontrasting

confidence: 47%

“…Nonetheless, some of these findings deserve some comment with respect to our present findings. First, Bernstein et al (6) have argued that desensitization of P-adrenoceptors during chronic hypoxia is due to a decrease in total cell receptor number and is not associated with receptor sequestration from sarcolemmal membrane to cytosolic sites, implying therefore that the changes in the P-adrenoceptor activity was a result of their down-regulation. In the present study, we observed a parallel increase in the a-adrenoceptor, and a parallel decrease in P-adrenoceptor responsiveness to ligand binding with receptor density.…”

Section: Discussionmentioning

confidence: 99%

“…In congenital heart diseases, cyanosis has been associated with various alterations in cardiac sympathetic activity (1)(2)(3)(4)(5)(6). In acute hypoxemia, for example, stimulation of the sympathetic activity results in increased heart rate and cardiac output as a compensatory mechanism to maintain adequate oxygen supply (7,8), whereas in chronic situations, such as in cyanotic congenital heart disease, several complex events probably contribute toward the mechanism(s) to sustain adequate oxygen supply (9).…”

mentioning

confidence: 99%

“…In acute hypoxemia, for example, stimulation of the sympathetic activity results in increased heart rate and cardiac output as a compensatory mechanism to maintain adequate oxygen supply (7,8), whereas in chronic situations, such as in cyanotic congenital heart disease, several complex events probably contribute toward the mechanism(s) to sustain adequate oxygen supply (9). In animal models of chronic congenital cardiac disorders, the cardiac output returns to normal, but the sympathetic tone remains elevated (5,6). Such a persistently elevated sympathetic tone may be a result of chronic stimulation of adrenoceptors by catecholamines and can ultimately lead to down-regulation of especially P-adrenoceptor density (10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Regulation of Sympathetic Activity in Children with Various Congenital Heart Diseases

Dzimiri¹,

Galal

Moorji³

et al. 1995

Pediatr Res

View full text Add to dashboard Cite

We studied the a-and P-adrenoceptor activity and catecholamine and cAMP levels in 112 children and infants admitted to the hospital for diagnostic or inte~entional catheterization of tetralogy of Fallot, ventricular septa1 defects with or without hypertension, pulmonary stenosis, coarctation of the aorta, and various complex cyanotic congenital cardiac diseases and compared them with 14 children undergoing transcatheter occlusion of patent ductus arteriosus with insignificant left-to-right-shunts. The mean total platelet a-adrenoceptor density of the study population was elevated by 73%. Both the increases in acyanotic ( p < 0.05) and cyanotic ( p < 0.005) patients as well as the difference between the two groups ( p < 0.01) were significant.Based on the congenital disease classification, the elevation in receptor density was also significant in all groups of patients, except coarctation of the aorta. On the other hand, the mean lymphocyte P-adrenoceptor density was attenuated by 27%, showing significant difference between the acyanotic and the patent ductus arteriosus groups, but none between acyanotic and cyanotic or cyanotic and the patent ductus arteriosus groups. Among the congenital groups, only the left-to-right shunts and the pulmonary stenosis group showed significant ( p < 0.05) decrease in P-adrenoceptor density, whereas the affinity of all the groups toward [125~]iodocyanopindolol was hardly influenced. The plasma levels of all three catecholamines, norepinephrine, epinephrine, and dopamine, were elevated, but cAMP remained unchanged. It seems that the sympathetic nervous system responds to changes triggered by some congenital heart diseases by stimulating a-adrenoceptors, which may be further increased by cyanosis and an attenuation of P-adrenoceptors associated with an increase in plasma catecholamine levels. (Pediatr Res 38: 55-60, 1995) Abbreviations ACY, acyanotic group CYN, cyanotic group TOF, tetralogy of Fallot LRS, left-to-right shunts PST, pulmonary stenosis COA, coarctation of the aorta CPL, complex cyanotic heart diseases PDA, patent ductus arteriosus QpIQs ratio, ratio of pulmonary blood flow to systemic blood flow

show abstract

Cardiopulmonary Bypass

Anesthesiologist

2009

Anesthesia for Congenital Heart Disease

View full text Add to dashboard Cite

Differential regulation of right and left ventricular beta-adrenergic receptors in newborn lambs with experimental cyanotic heart disease.

Cited by 29 publications

References 37 publications

Effects of Pulmonary Insufficiency on Biventricular Function in the Developing Heart of Growing Swine

Effects of Pulmonary Insufficiency on Biventricular Function in the Developing Heart of Growing Swine

Regulation of Sympathetic Activity in Children with Various Congenital Heart Diseases

Cardiopulmonary Bypass

Contact Info

Product

Resources

About