1998
DOI: 10.1002/(sici)1097-4695(19980205)34:2<164::aid-neu6>3.0.co;2-0
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Differential regulation of levels of nicotinic receptor subunit transcripts in adult sympathetic neurons after axotomy

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Cited by 48 publications
(53 citation statements)
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“…The transcript levels of ␣ 3 -, ␣ 5 -, ␣ 7 -and ␤ 4 -but not ␤ 2 -subunits in the SCG neurons have been shown to decrease in chronically denervated, but not decentralized, rat SCGs (11,48,51,52), suggesting that ␣ 3 ␤ 2 -nAChR and other subunits including ␣ 3 ␤ 4 -and ␣ 7 -nAChRs are located mainly on the postganglionic neurons of the SCGs. This finding allows a reasonable prediction that ␣ 3 ␤ 2 -nAChRs are present on the sympathetic nerve terminals on the arterial wall, mediating nicotine-induced cerebral neurogenic nitrergic vasodilation.…”
Section: Discussionmentioning
confidence: 98%
“…The transcript levels of ␣ 3 -, ␣ 5 -, ␣ 7 -and ␤ 4 -but not ␤ 2 -subunits in the SCG neurons have been shown to decrease in chronically denervated, but not decentralized, rat SCGs (11,48,51,52), suggesting that ␣ 3 ␤ 2 -nAChR and other subunits including ␣ 3 ␤ 4 -and ␣ 7 -nAChRs are located mainly on the postganglionic neurons of the SCGs. This finding allows a reasonable prediction that ␣ 3 ␤ 2 -nAChRs are present on the sympathetic nerve terminals on the arterial wall, mediating nicotine-induced cerebral neurogenic nitrergic vasodilation.…”
Section: Discussionmentioning
confidence: 98%
“…For example, denervation of neonatal rat superior cervical ganglion (SCG) neurons decreases all nAChR subunit mRNAs, but not ACh-induced current densities (Mandelzys et al, 1994). At later adult stages, however, the maintenance of mature nAChR subunit transcript levels may be less dependent on preganglionic tissue interactions (Fumagalli et al, 1978;Zhou et al, 1998). Studies of frog sympathetic and parasympathetic ganglia also show that whole-cell ACh-sensitivity is not altered by deafferentation (Dunn and Marshall, 1985;Streichert and Sargent, 1992).…”
Section: Maintenance Of Nachr Expression Requires Innervationmentioning
confidence: 99%
“…The large declines in AChinduced currents caused by axotomy are in sharp contrast to the lack of change after denervation. Similarly, postganglionic axotomy or nerve crush of the adult rodent SCG causes large reductions in synaptic transmission and expression of nAChR subunits (Purves, 1975;Fumagalli and De Renzis, 1980;Zhou et al, 1998Zhou et al, , 2001Yeh et al, 2001;Zaccaria et al, 2001).…”
Section: Maintenance Of Nachrs Also Requires Target Tissue Interactionsmentioning
confidence: 99%
“…Postganglionic nerve transection of the adult rat SCG leads to a decrease in the transcript levels of ␤4 subunits in SCG neurons. In contrast, ␤2 transcripts remain almost at the control level and may even slightly increase 3 days after postganglionic axotomy (Zhou et al, 1998). ␤ subunits contribute to the nAChR channels and ACh-binding sites, which are believed to be at interfaces between ␣ and ␤ subunits.…”
mentioning
confidence: 97%
“…However, only 5 of the 12 nAChR subunits (␣3, ␣5, ␣7, ␤2, and ␤4) are known to exist in autonomic ganglia (Mandelzys et al, 1994;Zhou et al, 1998;Devay et al, 1999;Nelson and Lindstrom, 1999;Erkman et al, 2000), and they are not distributed homogenously (Covernton et al, 1994;Klimaschewski et al, 1994;Poth et al, 1997;Sivilotti et al, 1997). Different nAChR subunit combinations are spatially segregated from each other in discrete membrane microregions relative to synapses (Horch and Sargent, 1995;Poth et al, 1997;Shoop et al, 1999).…”
mentioning
confidence: 99%