Differential regulation of gap junctions by proinflammatory mediators in vitro.

Abstract

The development of inflammation is an important component of host defense against infection. The cellular and molecular processes underlying inflammation are well-studied, and it is known that cells

Inhibition of Endothelial Cell Migration, Intercellular Communication, and Vascular Tube Formation by Thromboxane A2

“…Indeed, endothelial cell migration and angiogenesis are sensitive to inhibition of gap junction-mediated intercellular communication, and antiangiogenic cytokines, such as interleukin-1␤, potently inhibit intercellular communication in endothelium (37)(38)(39). Inhibition of junctional communication alone is not sufficient to explain the loss of EC function, however, since many proangiogenic G-proteinlinked receptor ligands also decrease junctional communication (40,41).…”

Regulation of Gap Junctional Communication by a Pro-Inflammatory Cytokine in Cystic Fibrosis Transmembrane Conductance Regulator-Expressing but Not Cystic Fibrosis Airway Cells

“…18 However, little is known about the role of gap junctional communication in the inflammatory process. Some studies have documented alteration in gap junction protein connexin (Cx) expression and intercellular communication by pro-inflammatory mediators in endothelial, 19,20 hepatic, 21,22 cardiac, 23 and Schwann cells. 24 Whether gap junctional communication is affected in human airway cells during the inflammatory process remains to be established.…”

Closing the Gap at Hot Spots

“…9 An inhibition was reported for inflammatory mediators, which selectively attenuated the permeability of myoendothelial junctions in vitro. 10 Sepsis also reduced electrical intercellular coupling and the propagation of conducted constrictions in vivo, 11 possibly in an NO-dependent fashion. 12 Such an inhibition of the propagation of constrictions can also be exerted by the physiologically released amounts of NO most likely reflecting inhibition of homocellular smooth muscle coupling.…”