“…Previous studies have demonstrated that melatonin stimulates the proliferation of avian astrocytes, dentate neurons and hippocampal neurons (17,18). The action of melatonin is mediated through a receptor-dependent signaling pathway (19). Additionally, melatonin has free radical scavenging and antioxidant properties, which can decrease malondialdehyde levels and may reverse the ischemia-reperfusion injury of the sciatic nerve (12).…”