Abstract:Compared to αβT cells, γδT cells are more innate-like and preferentially function as the first line of defense in barrier tissues. Certain populations of γδT cells possess adaptive immune cell properties but their regulation is not well understood. We herein report that while innate-like γδT17 cells dominated in the skin of WT mice, Vγ1.1 + γδT cells with adaptive T cell-like properties predominantly expanded in the skin of TCRβ -/and B2m -/mice. Commensal bacteria drove expansion of Vγ1.1 + skin γδT cells, fu… Show more
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