Differential Regulation of Basic Helix-Loop-Helix Factors Mash1 and Olig2 by β-Amyloid Accelerates Both Differentiation and Death of Cultured Neural Stem/Progenitor Cells

Uchida, Yuzo; Nakano, Shun-ichirou; Gomi, Fujiya; Takahashi, Hiroshi

doi:10.1074/jbc.m703099200

Cited by 34 publications

(28 citation statements)

References 36 publications

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“…It is therefore of special interest in investigating the changes of Aβ or phosphorylated Tau protein levels in the STZ-treated and RCE -protected rats. Studies have already indicated that Aβ might cause deterioration of the brain microenvironment which is important for neurogenesis of NSCs [63], [64]. A recent study also showed that salidroside has protective effects against Aβ-induced oxidative stress in SH-SY5Y human neuroblastoma cells [48].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat

et al. 2012

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Previously we have demonstrated that a Rhodiola crenulata extract (RCE), containing a potent antioxidant salidroside, promotes neurogenesis in the hippocampus of depressive rats. The current study was designed to further investigate the protective effect of the RCE on neurogenesis in a rat model of Alzheimer's disease (AD) induced by an intracerebroventricular injection of streptozotocin (STZ), and to determine whether this neuroprotective effect is induced by the antioxidative activity of salidroside. Our results showed that pretreatment with the RCE significantly improved the impaired neurogenesis and simultaneously reduced the oxidative stress in the hippocampus of AD rats. In vitro studies revealed that (1) exposure of neural stem cells (NSCs) from the hippocampus to STZ strikingly increased intracellular reactive oxygen species (ROS) levels, induced cell death and perturbed cell proliferation and differentiation, (2) hydrogen peroxide induced similar cellular activities as STZ, (3) pre-incubation of STZ-treated NSCs with catalase, an antioxidant, suppressed all these cellular activities induced by STZ, and (4) likewise, pre-incubation of STZ-treated NSCs with salidroside, also an antioxidant, suppressed all these activities as catalase: reduction of ROS levels and NSC death with simultaneous increases in proliferation and differentiation. Our findings indicated that the RCE improved the impaired hippocampal neurogenesis in the rat model of AD through protecting NSCs by its main ingredient salidroside which scavenged intracellular ROS.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat

et al. 2012

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“…In AD, soluble species of A␤42 are more strongly correlated with disease symptoms than with amyloid plaques (5)(6)(7)(8)(9). A␤42 was also reported to have an effect on differentiation and death of cultured neural stem or progenitor cells (10). Intraneuronal A␤ accumulation in brains of patients with AD, in animal models, and in cultured cells has suggested a pathophysiological role specific for A␤40 and A␤42 (11).…”

mentioning

confidence: 99%

Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription*

Barucker

Harmeier

Weiske

et al. 2014

Journal of Biological Chemistry

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Background: Biological activities of nontoxic A␤42 peptides remain unclear in Alzheimer disease. Results: A␤ species are taken up in the nucleus of cells by a nonregulated mechanism, but only A␤42 plays a role in gene transcription. Conclusion: A␤42 may act as a transcriptional regulator, similar to the cytoplasmic fragment AICD. Significance: Genes regulated by nuclear A␤42 could represent alternative targets for therapeutic approaches.

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“…Mash1 or ASC1 is one of the basic helix-loop-helix (bHLH) transcription factors that heterodimerizes with the ubiquitous Class I bHLH E proteins to form complexes that are crucial in neurogenesis and neural differentiation during development (43 found in the adult cerebral cortex and giving rise to the ganglionic eminence and olfactory epithelium (44,45). A study using Mash1 null mutant mice showed that Mash1 is required for the generation of an early population of oligodendrocyte precursors (OPCs), which is involved in the regulation of synaptic transmission and adult neurogenensis (46).…”

Section: Discussionmentioning

confidence: 99%

Angelman Syndrome: Proteomics Analysis of an UBE3A Knockout Mouse and Its Implications

Loon¹,

Chen²,

Chen³

et al. 2012

Advanced Topics in Neurological Disorders

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Differential Regulation of Basic Helix-Loop-Helix Factors Mash1 and Olig2 by β-Amyloid Accelerates Both Differentiation and Death of Cultured Neural Stem/Progenitor Cells

Cited by 34 publications

References 36 publications

Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat

Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat

Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription*

Angelman Syndrome: Proteomics Analysis of an UBE3A Knockout Mouse and Its Implications

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