Differential Pulse Voltammetric Studies on Lamivudine: An Antiretroviral Drug

Leandro, Kátia Christina; Moreira, Josino Costa; Farias, Pércio Augusto Mardini

doi:10.4236/ajac.2013.46a007

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…Based on their medicinal and pharmacological significance, evaluating appropriate levels of 3TC in biological fluids and pharmaceutical preparations is tremendously essential. The analytical methods for assessing 3TC levels have been repeatedly reported, such as spectrophotometry [6, 7], chromatography [8], electrochemistry [9][10][11][12], etc. The chromatography and spectrophotometry methods have presented good selectivity and detection limits.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Ariyanta

Roji

Apriandanu

2022

Micro and Nano Syst Lett

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The phytosynthesis method was used to prepare ZnO nanoparticles (ZnO NPs) via Senna alata L. leaf extract (SALE) by involving alkaloids, which play an essential role as a source of weak bases during the formation reaction of NPs. ZnO NPs on glassy carbon electrodes (GCE/ZnO NP) have been introduced to investigate its electrochemical activity towards the antiretroviral drug, lamivudine (3TC). Several characterization techniques, such as Fourier Transform Infra-Red (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDS), and Dynamic Light Scattering (DLS) techniques were employed to analyze the properties of GCE/ZnO NPs. As a result, ZnO NPs in spherical shape showed a high purity crystalline hexagonal wurtzite structure with a particle diameter of 40–60 nm. A Cyclic Voltammetry (CV) measurement confirmed that the electrochemical reduction of 3TC on GCE/ZnO NPs exhibited an excellent linear range of 10–300 µM with a detection limit of 1.902 µM, quantitation limit of 6.330 µM, and sensitivity of 0.0278 µA/µM. Thus, this research suggests a facile method for the preparation of material-based ZnO NPs as a promising antiretroviral drug sensors due to their excellent electrochemical properties.

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Section: Introductionmentioning

confidence: 99%

Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Ariyanta

Roji

Apriandanu

2022

Micro and Nano Syst Lett

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“…Paracetamol generally suffers from the interferences such as p-aminophenol, caffeine, ascorbic acid, uric acid and glucose [23,24]. Hence, in this study a systematic study of interference due to the presence of uric acid only [12,32,36]. The interference uric acid was examined on activated glassy carbon electrode on the determination of paracetamol.…”

Section: Interference Study On the Behaviour Of Paracetamolmentioning

confidence: 99%

Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode

Ayalew¹,

Ayitegeb²

2021

AJPC

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The electrochemical property of paracetamol was investigated at a glassy carbon electrode and activated glassy carbon electrode. Differential pulse voltammetry and cyclic voltammetry were used as diagnostic techniques in the determination of paracetamol. The activated glassy carbon electrode exhibited excellent electro-catalytic behaviour for the oxidation of PAR as evidenced by the enhancement of the oxidation peak current and the shift in the oxidation peak potential to less positive values by (13mv) in comparison with a bare GCE. In the present work the activated glassy carbon electrode was prepared by activating 200 s in a time base technique at a potential of 1750 mV. The electrode process of paracetamol was studied and some the experimental parameters which affect the response paracetamol, such as pH, effect of PAR concentration and scan rate on AGC electrode. The analysis of cyclic voltammogram gave fundamental electrochemical parameters including the electroactive surface coverage, the electron transfer coefficient and the heterogeneous rate constant (k s ). The variation of scan rate study shows that the system undergoes adsorption controlled process. The equation of the calibration curve was found to be: I p =0.429C + 6.43, R 2 =0.993. The LOD and LOQ for the developed method were determined to be 8×10 -8 mol L -1 and 2.6×10 -7 mol L -1 respectively. Phosphate buffer pH 7.0 was selected for analytical purpose.

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Highly dispersed Cu and Ni nano cluster sensor for ultrasensitive electrochemical detection of antiviral drug lamivudine

Wei

Yifeng

et al. 2023

Microchim Acta

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Differential Pulse Voltammetric Studies on Lamivudine: An Antiretroviral Drug

Cited by 7 publications

References 12 publications

Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode

Highly dispersed Cu and Ni nano cluster sensor for ultrasensitive electrochemical detection of antiviral drug lamivudine

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