Differential pulse voltammetric determination of methyldopa using MWCNTs modified glassy carbon decorated with NiFe2O4 nanoparticles

Abstract

A nanosensor was introduced for a sensitive determination of methyldopa using multiwall carbon nanotubes (MWCNTs) decorated with ferrite nickel nanoparticles (NiFe 2 O 4 ) on a glassy carbon electrode. The electrochemical activity of the modified electrode for the determination of methyldopa was investigated using differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy. The results showed that the modified electrode exhibits synergistic activity to the oxidation of methyldopa. The influence of several parameters that affect the response of the modified electrode was studied. A wide linear dynamic range of 0.5 to 900 μmol L −1 methyldopa with a detection limit of 0.08 μmol L −1 was achieved using differential pulse voltammetry. The interference of foreign substances on the selectivity of the electrochemical sensor was evaluated. Finally, the proposed method was successfully applied for the determination of methyldopa in real samples such as human urine, tablet, and plasma with satisfactory results.

Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa

“…Indeed, the low consumption of reagents, cheapness of electrochemical apparatus, combined with good sensibility, broad applicability, and suitable selectivity are some of the main attractive features of this method. Moreover, both sensibility and selectivity can be improved by changes in electrode matrix composition [12,13,14,15,16,17,18,19,20,21].…”

Electrochemical Sensor Based on Carbon Nanotubes Decorated with ZnFe2O4 Nanoparticles Incorporated Carbon Paste Electrode for Determination of Metoclopramide and Indomethacin

“…The result for carboxylated MWCNTs (curve a) includes peaks at 1640 and 1382 cm −1 reflecting the presence of C=O and C–O stretchings. Two weak signals at 2935 and 2840 cm −1 were attributed to the stretching mode of –CH, and the broad band at 3440 cm −1 was attributed to the stretching vibration of ‐OH band of the carboxylate groups on the surface of MWCNTs . In the case of ZnFe 2 O 4 /MWCNTs (curve b) the bands at 1385 cm −1 and 820 cm −1 correspond to the stretching of Zn‐O−Fe bonds in the tetrahedral building blocks of the spinel ferrite and the band at 590 cm −1 was assigned to the stretching of the Fe−O bond …”

“…Carbon nanotubes (CNTs), as an instance of such carbon matrices, is commonly used as templates in electrochemical and bioelectrochemical sensors, given their great surface area, electrical conductivity, the special whole structure, excellent chemical stability, and low cost . To tap into the potential advantages of both these ingredients, i. e. ferrite nanoparticles and CNTs, different modified CNTs have been decorated with nanoparticles such as CoFe 2 O 4 , NiFe 2 O 4 MnFe 2 O 4 , and ZnFe 2 O 4 . As opposed to other analytical tools, electrochemical sensors offer different advantages of simplicity, stability, reproducibility, reasonable analysis time, and costs …”

Efficient Catalytic Activity of Ionic Liquid-Supported NiFe2O4 Magnetic Nanoparticle Doped Titanium Dioxide Nano-Composite

“…The nickel ferrite magnetite nanoparticle was prepared according to the previous method [29], [30]. Briefly, 1.0 gram of nickel ferrite magnetic nanoparticle NiFe 2 O 4 and N-(2′, 3 ′ -epoxypropyl)-N-methyl-2-pyrrolidonium salicylate ionic liquid (IL) were taken separately.…”