Differential-Pulse Polarographic Determination of Some N-Substituted Phenothiazine Derivatives in Dosage Forms and Urine Through Treatment with Nitrous Acid

Belal, F.; El‐Ashry, Saadia M.; Shehata, Ihsan M.; El‐Sherbeny, Magda A.; El-Sherbeny, Dina T.

doi:10.1007/s006040070004

Cited by 48 publications

(25 citation statements)

References 1 publication

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“…The following formulas were applied: On the basis of the data included in Table 1, it can be said that the developed SWV and DPV methods have good sensitivity, which is proved by the obtained LOD and LOQ values. This also shows that procedures using the BDD electrode are more sensitive than those using the GC electrode 20,21 and Hg electrode 16 or different metallic electrodes (e.g. Pt, Ru, Au).…”

Section: Validation Of the Analytical Proceduresmentioning

confidence: 78%

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Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode

Mielech-Łukasiewicz

Staskowska

2015

ANAL. SCI.

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Section: Validation Of the Analytical Proceduresmentioning

confidence: 78%

“…In the literature we can find descriptions of polarographic methods involving oxidation of phenothiazine derivatives to sulfoxides, followed by their reduction at dropping mercury electrode. 16 Voltammetric methods described in the literature make use of metallic electrodes (e.g. Pt, Au, Ru) [17][18][19] and different carbon electrodes.…”

Section: Introductionmentioning

confidence: 99%

Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode

Mielech-Łukasiewicz

Staskowska

2015

ANAL. SCI.

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“…These include spectrofluorimetry [5], chemiluminescence [6], high performance liquid chromatography [7][8][9][10], voltammetry [11][12][13], differential pulse stripping voltammetry [14][15][16][17], polarography [18,19], and electrophoresis [20][21][22][23][24], visible spectrophotometry [25][26][27][28][29] and a combination of the previous ones [30]. These methods exhibit excellent selectivity, but require expensive instrumentation and are unsuitable for screening in the local under survey.…”

Section: Introductionmentioning

confidence: 99%

Disposable solid state probe for optical screening of chlorpromazine

Guerreiro

Sales

2011

Microchim Acta

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We are presenting a simple, low-cost and rapid solid-state optical probe for screening chlorpromazine (CPZ) in aquacultures. The method exploits the colourimetric reaction between CPZ and Fe(III) ion that occurs at a solid/liquid interface, the solid layer consisting of ferric iron entrapped in a layer of plasticized PVC. If solutions containing CPZ are dropped onto such a layer, a colour change occurs from light yellow to dark pink or even light blue, depending on the concentration of CPZ. Visual inspection enables the concentration of CPZ to be estimated. The resulting colouration was also monitored by digital image collection for a more accurate quantification. The three coordinates of the hue, saturation and lightness system were obtained by standard image processing along with mathematical data treatment. The parameters affecting colour were assessed and optimized. Studies were conducted by visible spectrophotometry and digital image acquisition, respectively. The response of the optimized probe towards the concentration of CPZ was tested for several mathematical transformations of the colour coordinates, and a linear relation was found for the sum of hue and luminosity. The limit of detection is 50 μM (corresponding to about 16 μg per mL). The probe enables quick screening for CPZ in real water samples with prior sample treatment.

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“…Because of the importance of this class of compounds, a lot of work has been reported on their characterization and determination in dosage forms and biological fluids. The methods used for their study included electroanalysis [1,2], spectrophotometry [3][4][5], chemiluminescence [6] and HPLC [7] etc. That has been reviewed by Korpinsk et al [8].…”

Section: Introductionmentioning

confidence: 99%

“…That has been reviewed by Korpinsk et al [8]. The electrochemical methods for phenothiazines mainly include potentiometry and voltammetry, based on their electroactivity or redox property [1,2,9]. For example, Golabi et al have attempted potentiometric titration for the determination of phenothiazine derivatives [9].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Prochlorperazine and Ethopropazine Using a Gold Electrode Modified with Decanethiol SAM

Yang

Peng

Zhao

et al. 2003

Sensors

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Abstract:The voltammetric behavior of prochlorperazine and ethopropazine at a decanethiol (DEC) self-assembled monolayer (SAM) modified gold electrode (DEC/Au) has been studied. It was observed that prochlorperazine exhibited an anodic peak at about 0.60 V (vs SCE), while ethopropazine exhibited two anodic peaks at about 0.49 V and 0.58 V on DEC/Au in pH 10 sodium carbonate buffer. This was due to their different electrochemical oxidation mechanisms. In this case, the oxidation of prochlorperazine and ethopropazine included one 2e step and two 1e steps, respectively. In the presence of some reductants such as ascorbic acid, the oxidation products of them can catalyze the oxidation of the reductants and thus make the peaks grow. In addition, it was found that the SAM structure became not so compact when prochlorperazine and ethopropazine were present, resulting from their permeating in the SAM. Various conditions were optimized for their determination. Under the selected conditions (i.e. 0.080 M pH 10 sodium carbonate buffer; scan rate: 100 mV/s; accumulation potential: -0.4 V or 0 V; accumulation time: 60 s), the peak currents were linear to prochlorperazine concentration in the ranges of 0.1~2.0 M and 5.0~50 M, and linear with ethopropazine in the ranges of 10 nM~0.1 M and 0.5~20 M. The RSD was 4.28% for 8 successive measurements of 1.0 M prochlorperazine. The influence of some coexistents was examined.

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Differential-Pulse Polarographic Determination of Some N-Substituted Phenothiazine Derivatives in Dosage Forms and Urine Through Treatment with Nitrous Acid

Cited by 48 publications

References 1 publication

Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode

Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode

Disposable solid state probe for optical screening of chlorpromazine

Voltammetric Determination of Prochlorperazine and Ethopropazine Using a Gold Electrode Modified with Decanethiol SAM

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