Differential pulse polarographic determination of 2,3-dimercaptosuccinic acid and tin(II) in radiopharmaceuticals

Ross, Andréanne; Moore, Herbert; Ritter, Cl.; Moros, S.A.

doi:10.1002/jps.2600680541

Cited by 5 publications

(2 citation statements)

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“…Although a colorimetric assay using Ellman's reagent, 5,5 -dithiobis (2-nitobenzoic acid), has been reported for the quantitative determination of DMSA in whole blood [14], the sensitivity and selectivity has been unsatisfactory due to the susceptibility of the SH groups to oxidation. A polarographic procedure, quantifying DMSA in pharmaceutical preparations, has also been described elsewhere [15], but the method was also non-specific when applied to sample matrices containing many potentially electroactive components.…”

Section: Introductionmentioning

confidence: 99%

Determination of 2,3-dimercaptosuccinic acid in mice blood and tissues by HPLC with fluorescence detection

Shi

Liu

et al. 2009

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Determination of 2,3-dimercaptosuccinic acid in mice blood and tissues by HPLC with fluorescence detection

Shi

Liu

et al. 2009

Journal of Chromatography B

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“…meso-DMSA can be detected after derivatization by fluorescent reagent monobromobimane (mBBr) by HPLC [5,6] and by N,Obis(trimethylsilyl) acetamide by GC [7]. Besides the described methods, spectrophotometric [8] and polarographic [9] techniques have also been developed to quantify meso-DMSA. However, these methods are time-consuming, not cost-effective or non-specific.…”

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confidence: 98%

Analysis of meso -2,3-dimercaptosuccinic acid in human urine by capillary electrophoresis using direct injection

Zhu

Lever

2003

Analytical and Bioanalytical Chemistry

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meso-2,3-Dimercaptosuccinic acid ( meso-DMSA) is an effective chelating agent for the treatment of lead poisoning. We have developed a capillary electrophoresis (CE) method to monitor the urinary excretion of meso-DMSA in human beings. The urine sample was directly injected for analysis in CE without the requirement of solid-phase extraction (SPE). The meso-DMSA was detected in 20 mM borate buffer (pH 8.3) using a 60-cm length bare fused-silica capillary (75-microm ID, 52.5-cm effective length). The meso-DMSA can be extensively biotransformed during metabolism, and no meso-DMSA in urine samples was found in our studies. Any metabolized meso-DMSA can be successfully converted to free meso-DMSA by chemical reduction with dithiothreitol (DTT). In addition, samples were also treated with ethylenediaminetetraacetic acid (EDTA) to transchelate any meso-DMSA that is coordinated with metal ions present in the urine samples. The total amount of meso-DMSA present as these chemical forms was quantified after chemical reduction and addition of EDTA. The detection limit of meso-DMSA was about 50 microM, the RSD of peak area and migration time of meso-DMSA were 4-8% and less than 1%, respectively.

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Gas chromatographic analysis of urinary dimercaptosuccinic acid

Knudsen

McGown

1988

Journal of Chromatography B: Biomedical Sciences and Applicatio

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Differential pulse polarographic determination of 2,3-dimercaptosuccinic acid and tin(II) in radiopharmaceuticals

Cited by 5 publications

References 9 publications

Determination of 2,3-dimercaptosuccinic acid in mice blood and tissues by HPLC with fluorescence detection

Determination of 2,3-dimercaptosuccinic acid in mice blood and tissues by HPLC with fluorescence detection

Analysis of meso -2,3-dimercaptosuccinic acid in human urine by capillary electrophoresis using direct injection

Gas chromatographic analysis of urinary dimercaptosuccinic acid

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