Differential-pulse polarographic determination of isonicotinic acid hydrazide, and analogous hydrazides in admixture

Sulaiman, Sadallah T.; Hameed, Y.O.

doi:10.1016/s0003-2670(00)80862-4

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…The first one is attributed to amide group reduction, after transference of two electrons; the second corresponds to reduction of pyridinic ring involving the same number of electrons. Sulaiman and Hameed (1988) reported the determination of isoniazid and other hydrazides using the polarography of differential pulse, which was applied in the determination of a ternary mixing with other hydrazides. Rodrigues-Mellado et al (1993) have studied the oxidation of isoniazid on mercury electrode, in a pH interval between 6 and 13.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Leandro

Carvalho

Giovanelli

et al. 2009

Braz. J. Pharm. Sci.

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Tuberculosis remains a major public health problem, especially in developing countries. Brazil presents the largest number of cases in Latin America and is among the 22 countries considered priorities by the World Health Organization (WHO). The Rio de Janeiro state has the largest number of cases registered in the country. The treatment of patients, commonly, makes use of the drugs isoniazid and rifampicin for six months. This study aimed to develop and validate an electroanalytical methodology, using the technique of differential pulse voltammetry for the determination of these drugs in the associated form, in order to evaluate the quality of medicines distributed in the state of Rio de Janeiro. The potential reduction for the isoniazid and rifampicin were -1.10 and -0.90 V. The developed and validated electroanalytical method presented a linear range of 0.25 to 1.25 mg/L to isoniazid, limits of detection and quantification of 0.05 and 0.14 mg/L, and recovery of 98.2 ± 0.4%; a tracking linear of 0.40 to 2.00 mg/L for rifampicin, with limits of detection and quantification of 0.07 and 0.19 mg/L and recovery of 95.8 ± 0.6%. Six lots of medicines from two pharmaceutical companies were analyzed. Only one of the samples showed unsatisfactory levels of rifampicin.Uniterms: Isoniazid. Rifampicin. Tuberculosis/treatment. Tuberculostatics/quantitative analysis. Differential pulse voltammetry.A tuberculose continua sendo um importante problema de saúde pública, especialmente em países em desenvolvimento. O Brasil apresenta o maior número de casos da América Latina, estando entre os 22 países considerados prioritários nas ações de controle da doença pela Organização Mundial da Saúde (OMS). No Brasil, o Rio de Janeiro é o estado com o maior número de casos registrados no país. O tratamento de doentes com tuberculose faz uso dos fármacos isoniazida e rifampicina durante seis meses. O presente trabalho objetivou desenvolver e validar metodologia eletroanalítica, utilizando a técnica de voltametria de pulso diferencial, para a determinação desses dois princípios ativos na forma associada e avaliar a qualidade dos medicamentos distribuídos no estado do Rio de Janeiro. Os potenciais de redução para a isoniazida e rifampicina foram respectivamente -1,10 e -0,90 V. O método eletroanalítico desenvolvido e validado apresentou para a isoniazida faixa linear de 0,25 a 1,25 mg/L, limites de detecção e quantificação de 0,05 e 0,14 mg/L e recuperação de 98,2 ± 0,4%; para a rifampicina faixa linear de 0,40 a 2,00 mg/L, limites de detecção e quantificação de 0,07 e 0,19 mg/L e recuperação de 95,8 ± 0,6%. Foram analisados 6 lotes de medicamentos de dois laboratórios farmacêuticos. Apenas uma das amostras apresentou teor de rifampicina insatisfatório.Unitermos: Isoniazida/determinação. Rifampicina/determinação. Tuberculostáticos/análise quantitativa. Tuberculose/tratamento. Voltametria de pulso diferencial/utilização.

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Section: Introductionmentioning

confidence: 99%

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Leandro

Carvalho

Giovanelli

et al. 2009

Braz. J. Pharm. Sci.

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“…Many analytical techniques have been proposed for the determination of isoniazid including fluorescence (2,3) , electroanalytical (4) , flow-injection chemiluminescene methods (5) , titrations (6,7) , atomic absorption spectrometry (8,9) chromatography (10) , capillaryelectrophoresis (11,12) and H 1 -NMR spectroscopy (13) . The above mentioned techniques are sensitive but expensive, Specetrophotometry (14,15) is still the technique of choice even today due to inherent simplicity.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometic Determination of Isoniazid (INH) Using 2,4-dinitro-1-flourobenzene (DNFB) – Application to Tablet

Al-Hammoshi¹

2012

J.Edu.Sci.

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A rapid, simple, reproducible and sensitive spectrohpotometric method for assay of (INH) was investigated. The method is based on the reaction of INH with 2,4-dinitro-1-flourobenzene reagent to give a highly colored species with maximum at λ 428 nm in aqueous medium of pH 10.3. Beer's law was obeyed in the range of (0.05-2.5) µg/ml with a molar Spectrophotometic Determination of Isoniazid (INH) Using 2,4-dinitro-1-… 2 absorptivity 2.7 x 10 4 l.mol l-1 cm-1 .The sandell index was 0.005 µg.cm-2 and the limit of detection was 0.00984 µg/ml. The accuracy (average recovery%) was 99.99% and the relative standard deviation (RSD) was better than ±1.0%. Also it was found that the product formed was in a ratio of 1:1 with a stability constant of 5.9 x 10 3 l.mol-1. The method was applied successfully to assay INH in pharmaceutical formulations and agreed well with its certified value and the British pharmacopoeia method.

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“…The electroanalytical methods described in literature for INZ determination in pharmaceutical formulations and human serum have demonstrated success [11][12][13][14][15][16][17][18]. The polarographic reduction of isoniazid drug has been studied by Ghoneim et al [15] using a square-wave adsorptive cathodic stripping procedure.…”

Section: Introductionmentioning

confidence: 99%

Determination of isoniazid in human urine using screen-printed carbon electrode modified with poly-l-histidine

Bergamini

Santos

Zanoni

2010

Bioelectrochemistry

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Differential-pulse polarographic determination of isonicotinic acid hydrazide, and analogous hydrazides in admixture

Cited by 12 publications

References 13 publications

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Spectrophotometic Determination of Isoniazid (INH) Using 2,4-dinitro-1-flourobenzene (DNFB) – Application to Tablet

Determination of isoniazid in human urine using screen-printed carbon electrode modified with poly-l-histidine

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