Differential Pulse Polarographic Determination of Submicrogram Quantities of Carmustine and Related Compounds in Biological Samples

Bartošek, I.; Daniel, Sonia; Sýkora, S.

doi:10.1002/jps.2600670836

Cited by 15 publications

(7 citation statements)

References 10 publications

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“…The second, indistinct peak observable at the voltammograms at higher pH values (Fig. 2) is not suited for analytical purposes, similarly as mentioned for polarographic methods 18 .…”

Section: Voltammetric Determination Of Stz and Bcnu At Hmdementioning

confidence: 87%

“…N-nitroso compounds are not stable in aqueous solutions 18,22 . The stabilities of the stock solutions of STZ, BCNU (c = 1 × 10 -3 mol l -1 ) and CCNU (c = 2 × 10 -4 mol l -1 ) in water were monitored for 30 days by measuring the absorbance at λ = 230 nm, where the absorption maximum of the N-nitroso chromophore appears 40 .…”

Section: Spectrophotometric Studies On Stz Bcnu and Ccnu Stabilitymentioning

confidence: 99%

“…Polarographic methods were also used for determination of BCNU and CCNU and structurally related nitrosoureas in pure form, capsules, blood 17 , plasma 18 , and for pharmacokinetic studies 19 . Stability studies of BCNU in aqueous 13,20 , mixed-solvent and nonaqueous media 21 were performed by colorimetry after its conversion to an azo compound or by reversed-phase HPLC with UV detection 22 .…”

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confidence: 99%

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Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Pecková

Vrzalová

Bencko

et al. 2009

Collect. Czech. Chem. Commun.

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Dedicated to the memory of Professor Jaroslav Heyrovský on the occasion of the 50th anniversary of the Nobel Prize for polarography.A hanging mercury drop electrode and a mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso groups. On the example of carmustine it was shown that its one-step reduction proceeds at substantially more negative potentials at amalgam electrode as compared with mercury electrode. Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5%) using DC voltammetry and differential pulse voltammetry. The achieved limits of determination lie mostly in the 10 -7 mol l -1 concentration range. The mentioned voltammetric methods were applied to determination of carmustine and lomustine in pharmaceutical formulations. Further, the mercury meniscus modified silver solid amalgam electrode was employed in a "wall-jet" amperometric detection cell in the determination of carmustine by flow injection analysis. Under optimized conditions (run electrolyte BrittonRobinson buffer of pH 7.0; flow rate 5.5 ml min -1 ; detection potential -1.5 V; injection volume 0.02 ml) the limit of quantitation 7.1 × 10 -6 mol l -1 was achieved.

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“…The second, indistinct peak observable at the voltammograms at higher pH values (Fig. 2) is not suited for analytical purposes, similarly as mentioned for polarographic methods 18 .…”

Section: Voltammetric Determination Of Stz and Bcnu At Hmdementioning

confidence: 87%

Section: Spectrophotometric Studies On Stz Bcnu and Ccnu Stabilitymentioning

confidence: 99%

mentioning

confidence: 99%

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Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Pecková

Vrzalová

Bencko

et al. 2009

Collect. Czech. Chem. Commun.

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“…I n uiuo experiments demonstrated a saturable process for indocyanine green uptake hy the liver (13,14) and a biexponential decline in plasma levels for rats, rabbits, dogs, and humans ( 5 , 6 , 9,15). Elimination of unchanged dye by the liver into bile has been thought to be the sole method for indocyanine green clearance.…”

Section: Weinkammentioning

confidence: 99%

“…Recently reported polarographic methods have the requisite sensitivit,y but are susceptible to interference from plasma components and also lack specificity (15). Patient pharmacokinetic studies of carmustine biodistribution have been performed using direct sample insertion chemicalionization mass spectrometry (5).…”

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confidence: 99%

Quantitation of Lipophilic Chloroethylnitrosourea Cancer Chemotherapeutic Agents

Weinkam

Liu²

1982

Journal of Pharmaceutical Sciences

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Distribution of 13N in rat tissues following intravenous administration of nitroso-labeled BCNU

Freed

McQuinn

Tilbury

et al. 1982

Cancer Chemother. Pharmacol.

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The concentrations of label in 16 major organs and tissues of pentobarbital-sedated normal male rats were measured at six time points ranging from 0.2 to 50 min after IV injection of the antitumor drug BCNU labeled in the nitroso position with cyclotron-produced nitrogen-13. Initial (12-s) concentrations in the lungs, kidneys, and heart were 41, 13, and 11 times the whole-body average, respectively. Time for clearance of the first 50% of the injected dose from the circulation was of the order of several seconds. Estimated first-pass extractions of 70% or more were noted in the heart, kidneys, brain, stomach, small intestine, muscle, fat, and bone. Washout of label from the heart and lungs was quite rapid, removing most of the initially extracted 13N from these organs by 2 min after injection. Label concentrations in the kidneys exceeded those in all other tissues studied between 2 and 50 min. Secondary accumulations of 13N were observed in muscle, skin, liver, small intestine, and fat. Label concentrations in a number of tissues closely paralleled the steadily decreasing concentration in blood for various intervals between 5 and 50 min. The results suggest that the toxic insult to lung tissue from IV administered BCNU is effected in a period of several minutes. They also suggest that intra-arterial administration of the drug would significantly raise the target/non-target dose ratio and lower the incidence of pulmonary toxicity.

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Differential Pulse Polarographic Determination of Submicrogram Quantities of Carmustine and Related Compounds in Biological Samples

Cited by 15 publications

References 10 publications

Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

Quantitation of Lipophilic Chloroethylnitrosourea Cancer Chemotherapeutic Agents

Distribution of 13N in rat tissues following intravenous administration of nitroso-labeled BCNU

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