Differential pulse cathodic voltammetric determination of floctafenine and metopimazine

Gazy, Azza A.; Hassan, Ekram M.; Abdel-Hay, Mohamed H.; Belal, Tarek S.

doi:10.1016/j.jpba.2006.11.006

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Reviewing literature in hand; few methods have been reported for quantitative estimation of MPZ including pharmacopoeial non aqueous titrimetric method (Pharmacopee Francaise, 1985), HPLC method for analysis of MPZ in human plasma in presence of its acid metabolite (Deg II) (Angelo et al, 1989), TLC densitometric method for determination of MPZ in pure and dosage form in presence of its oxidative degradation product (Deg I) (Metwally et al, 2006) and differential pulse voltammetric method for determination of MPZ and floctafenine (Gazy et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…No method was reported for determination of MPZ in presence of both oxidative and alkaline degradation products, where, the reported HPLC (Angelo et al, 1989) and TLC (Metwally et al, 2006) methods measured MPZ in presence of only one of the degradation products. Moreover; the reported TLC (Metwally et al, 2006) and voltammetric (Gazy et al, 2007) methods were not applied for determination of MPZ in plasma. Therefore, it was essential to develop a simpler and more selective method for determination of MPZ in presence of its different degradation products.…”

Section: Introductionmentioning

confidence: 99%

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Stability indicating HPTLC method for determination of Metopimazine in pharmaceutical formulation and human plasma

Naguib

Abdelrahman

2014

Beni-Suef University Journal of Basic and Applied Sciences

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Oxidative degradationAlkaline degradation HPTLC Pharmaceutical formulation a b s t r a c t Accurate, selective and sensitive stability indicating high performance thin layer chromatographic (HPTLC) method was developed and validated for determination of Metopimazine (MPZ) in presence of its degradation products; including the oxidative degradation product (Deg I) and the alkaline hydrolysis degradation product (Deg II; formerly reported as acid metabolite). The proposed method was applied for analysis of MPZ in pure form, pharmaceutical formulation (tablets) and human plasma over the concentration range of 0.4e1.4 mg band À1 with accuracy of mean percentage recovery 100.10 AE 0.941. The method depends on separation of MPZ from its degradation products on HPTLC silica gel 60 F 254 plates using chloroformemethanoleammonia (12:2:0.1, by volume) as developing system followed by densitometric measurement of bands at 254 nm. The method was validated according to ICH guidelines. The degradation products were well resolved from the pure drug with significantly different R f values (MPZ, R f ¼ 0.58, Deg I, R f ¼ 0.35 and Deg II, R f ¼ 0.03). The results obtained by the proposed method were statistically compared to the reported HPTLC method, and there was no significant difference between them regarding both accuracy and precision; indicating the ability of the proposed method to be used for routine analysis of drug product.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stability indicating HPTLC method for determination of Metopimazine in pharmaceutical formulation and human plasma

Naguib

Abdelrahman

2014

Beni-Suef University Journal of Basic and Applied Sciences

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A new spectrophotometric method for the quantitative determination of Metopimazine based on the absorbance of its sulfoxide

Mozgova,

Blazheyevskiy,

Kryskiw

et al. 2024

Chem. Pap.

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Metopimazine (MPZ) is a dopamine antagonist from the phenothiazine class of drugs. It has antiemetic properties and is used to treat nausea and vomiting, including those associated with cancer chemotherapy. We have proposed a new method for the quantitative determination of Metopimazine by spectrophotometry. The drug is determined using a difference spectrophotometric technique based on the absorbance of its previously prepared sulfoxide derivative (λmax = 355 nm, ε = 4.5 × 103 L/mol cm) relative to a solution of a non-derivatised drug. The sulfoxide derivative is formed quickly and quantitatively at room temperature by adding potassium caroate solution. The difference in the absorbance of solutions at 355 nm is proportional to the concentration of MPZ in the drug. The method is specific for an intact drug in the presence of oxidative and photochemical decomposition products and excipients. The linearity range is 0.9–30.0 μg/mL. Regression line equation: ΔA = 0.0061 × c (r = 0.999), where c is the MPZ concentration in μg/mL. The limit of quantitation, LOQ (10S), is 2.8 μg/mL. The possibility of quantitative determination of MPZ content in the bulk drug and tablets of Vogalen Lyok 7.5 mg with a relative standard deviation of 1.21% (δ = + 0.05%) and 1.38% (δ = – 0.67%), respectively, was shown. │δ│ < tα (0.95, n = 7) × RSD/√n, where δ = ($$\overline{x}$$ x ¯ –μ) × 100%/μ (μ—quantification data, given in the Certificate of Quality).

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Voltammetric techniques for the assay of pharmaceuticals—A review

Gupta

Jain

Radhapyari

et al. 2011

Analytical Biochemistry

461

201

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Differential pulse cathodic voltammetric determination of floctafenine and metopimazine

Cited by 5 publications

References 15 publications

Stability indicating HPTLC method for determination of Metopimazine in pharmaceutical formulation and human plasma

Stability indicating HPTLC method for determination of Metopimazine in pharmaceutical formulation and human plasma

A new spectrophotometric method for the quantitative determination of Metopimazine based on the absorbance of its sulfoxide

Voltammetric techniques for the assay of pharmaceuticals—A review

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