Differential Protective Effects of Volatile Anesthetics against Renal Ischemia–Reperfusion Injury In Vivo

Lee, H Thomas; Ota‐Setlik, Ayuko; Fu, Yulei; Nasr, Samih H.; Emala, Charles W.

doi:10.1097/00000542-200412000-00011

Cited by 208 publications

(197 citation statements)

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“…In addition, the protective effects against IR injury by volatile anaesthetics have been shown in the myocardium,14 brain,15 liver16 and kidney 17. These data suggest that inhaled anaesthetics may not necessarily exacerbate lung injury after CPB.…”

Section: Introductionmentioning

confidence: 83%

Isoflurane pre-treatment before cardiopulmonary bypass alleviates neutrophil accumulation in dog lungs

Gao²,

Liu³

et al. 2011

CardioVascular Journal of Africa

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ObjectiveThis study investigated the effect of isoflurane pre-treatment on cardiopulmonary bypass (CPB)-related lung injury.MethodsTwelve dogs were randomly divided into two groups of six each. In one group, 1.0 minimum alveolar concentration (MAC) of isoflurane was administered for 30 min before CPB, while the control group received no anaesthetic. Both groups then underwent 100 min of mild hypothermic CPB with 60-min aortic cross clamping. Haemodynamic parameters, respiratory mechanics and alveolar arterial oxygen difference (AaDO2) were measured during the experiment. One hundred and fifty minutes after CPB, lung tissue samples from the non-dependent and dependent portions of the left and right lungs were harvested for polymorphonulear leukocyte (PMNs) counts.ResultsFollowing CPB, within the control group, pulmonary vascular resistance (PVR) was significantly increased at 60, 120 and 180 min after declamping, AaDO2 deteriorated at 180 min post-declamping, and dynamic lung compliance (DLC) was reduced dramatically after declamping. Isoflurane pre-treatment before CPB significantly reduced PVR compared to the controls. AaDO2 was impaired at 180 min after declamping and DLC was decreased after declamping within the isoflurane group. No differences in AaDO2 and DLC were found between the isoflurane and control groups. At 180 min after declamping, the PMN count in both the non-dependent and dependent regions of the isoflurane pre-treated lungs was significantly lower than that of the controls.ConclusionsOur results suggest that 30-min pre-treatment with 1.0 MAC isoflurane before CPB caused a reduction in PMN accumulation in the dog lungs, inhibition of increases in PVR, and it did not affect AaDO2 in the early post-CPB stage.

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Section: Introductionmentioning

confidence: 83%

Isoflurane pre-treatment before cardiopulmonary bypass alleviates neutrophil accumulation in dog lungs

Gao²,

Liu³

et al. 2011

CardioVascular Journal of Africa

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“…These protective effects only occurred in rats treated with volatile anesthetics during both ischemia and reperfusion, and they were independent of the effects of these anesthetics on renal blood flow or blood pressure. [12] Other in vivo and in vitro studies of the same group also demonstrated that isoflurane [24] and sevoflurane [25] mediated protection from renal ischemia-reperfusion injury. On the other hand, a study [26] showed that preconditioning with sevoflurane did not protect the rat kidney from ischemia/reperfusion injury.…”

Section: Renal Variablesmentioning

confidence: 94%

“…Lee et al [12] demonstrated in rats that halogenated anesthetics (halothane, isoflurane, sevoflurane, and desflurane) reduce necrosis and inflammation and improve plasma creatinine after renal ischemia-reperfusion injury. These protective effects only occurred in rats treated with volatile anesthetics during both ischemia and reperfusion, and they were independent of the effects of these anesthetics on renal blood flow or blood pressure.…”

Section: Renal Variablesmentioning

confidence: 99%

“…[9][10][11] It was demonstrated that 1.0 minimum alveolar concentration (MAC) of halogenated anesthetics given both during and after renal ischemia protect against renal ischemia-reperfusion injury in rats. [12] The comparative effects of halogenated anesthetics halothane, isoflurane, and sevoflurane on renal function during hemorrhagic shock and resuscitation have not been studied.…”

Section: Introductionmentioning

confidence: 99%

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Does the Choice of the Halogenated Anesthetic Influence Renal Function during Hemorrhagic Shock and Resuscitation?

et al. 2009

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Introduction. Halogenated anesthetics can cause changes in the variables that modify the cardiac output necessary to maintain renal hemodynamic during hemorrhagic shock and resuscitation. However, halogenated anesthetics seem to protect against renal ischemia-reperfusion injury. In a model of pressure-guided hemorrhagic shock in dogs, we studied the comparative effects of three halogenated anesthetics-halothane, sevoflurane, and isoflurane-at equipotent concentrations on renal responses after resuscitation. Methods. Thirty dogs were anesthetized with 1.0 minimum alveolar anesthetic concentration (MAC) of halothane, sevoflurane, or isoflurane. The dogs were splenectomized and hemorrhaged to hold mean arterial pressure at 40-50 mm Hg over 45 min and then resuscitated with the shed blood volume. Hemodynamic variables were measured at baseline, after 45 min of hemorrhage, and 15 and 60 min after resuscitation. Renal variables were measured at baseline and 15 and 60 min after resuscitation. Results. Hemorrhage induced reductions of mean arterial pressure, filling pressures, and cardiac index (p < 0.05), without significant differences among groups (p > 0.05). After 60 min of shed blood replacement, all groups restored hemodynamic and renal variables to the prehemorrhage levels (p > 0.05), without significant differences among groups (p > 0.05), with the exception of sodium fractional excretion, the values for which were significantly higher in isoflurane group, in relation to the other groups after 15 min of re-transfusion (p < 0.05), and renal vascular resistance, the values for which remain lower than baseline in halothane group (p < 0.05). Conclusions. We conclude that no difference could be detected between choosing equipotent doses of halothane, sevoflurane, or isoflurane in relation to renal variables in dogs submitted to pressure-adjusted hemorrhagic shock and resuscitation.

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“…In comparison to other anesthetics, it has been reported that KX increases the infarct size in cerebral ischemia [8] , induces hyperglycemia in fed rodents [9] , reduces TNF-α expression in rat spleen [10] and influences lipopolysaccharide-induced endotoxemia [11] . Some anesthetics have cardio-or renoprotective effects which may be relevant to designing ischemia-reperfusion protocols [12,13] . They can affect the systemic hemodynamic [14] and may induce moderate to severe tissue damage [15] .…”

Section: Introductionmentioning

confidence: 99%

Effect of anesthetics on gastric damage using two models of portal hypertension

Câmara

Moi²,

Ferraz³

et al. 2010

WJGPT

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AIM:To investigate the effect of sodium pentobarbitone (SP) or ketamine/xylazine (KX) anesthetics on acute gastric injury. METHODS:Portal hypertension was induced by bile duct ligation (BDL) or portal vein stenosis (PVS). Ethanol (EtOH)-induced gastric damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow (GBF) was also measured by laser doppler flowmetry. RESULTS:EtOH-induced gastric damage was reduced in BDL rats under KX anesthesia in comparison to those under SP anesthesia. GBF dysfunction in fasted BDL rats was partially restored under KX anesthesia. In contrast, in fasted PVS rats, EtOH-induced gastric damage was increased under KX anesthesia while GBF was reduced. CONCLUSION:The use of KX anesthesia in experimental procedures involving cirrhotic rats (but not those with pure portal hypertension) is preferable to SP anesthesia. Câmara PRS, Moi GP, Ferraz JGP, Zeitune JMR. Effect of anes thetics on gastric damage using two models of portal hyperten sion.

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Differential Protective Effects of Volatile Anesthetics against Renal Ischemia–Reperfusion Injury In Vivo

Cited by 208 publications

References 0 publications

Isoflurane pre-treatment before cardiopulmonary bypass alleviates neutrophil accumulation in dog lungs

Isoflurane pre-treatment before cardiopulmonary bypass alleviates neutrophil accumulation in dog lungs

Does the Choice of the Halogenated Anesthetic Influence Renal Function during Hemorrhagic Shock and Resuscitation?

Effect of anesthetics on gastric damage using two models of portal hypertension

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