Differential physiological effects of neonicotinoid insecticides on honey bees: A comparison between Apis mellifera and Apis cerana

Li, Zhiguo; Li, Meng; He, Jie; Zhao, Xiaomeng; Chaimanee, Veeranan; Huang, Wei‐Fone; Nie, Hongyi; Zhao, Yazhou

doi:10.1016/j.pestbp.2017.06.010

Cited by 81 publications

(63 citation statements)

References 42 publications

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“…Different stimuli may elicit responses from different enzymes and different levels of activity. Hosts may respond differently to the challenges with different substances, and even to the same enzymes [59]. Host protease and chitinase enzymes are usually initially expressed at high levels after exposure to entomopathogenic fungi [44].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Entomopathogenic Fungus Metarhizium anisopliae on the Mortality and Immune Response of Locusta migratoria

Jiang

Peng

et al. 2019

Insects

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Entomopathogenic fungi are the key regulators of insect populations and some of them are important biological agents used in integrated pest management strategies. Compared with their ability to become resistant to insecticides, insect pests do not easily become resistant to the infection by entomopathogenic fungi. In this study, we evaluated the mortality and immune response of the serious crop pest Locusta migratoria manilensis after exposure to a new entomopathogenic fungus strain, Metarhizium anisopliae CQMa421. M. anisopliae CQMa421 could effectively infect and kill the L. migratoria adults and nymphs. The locust LT50 under 1 × 108 conidia/mL concentration of M. anisopliae was much lower than that under conidial concentration 1 × 105 conidia/mL (i.e., 6.0 vs. 11.2 and 5.0 vs. 13.8 for adults and nymphs, respectively). The LC50 (log10) of M. anisopliae against locust adults and nymphs after 10 days was 5.2 and 5.6, respectively. Although the number of hemocytes in L. migratoria after exposure to M. anisopliae did not differ with that in the controls, the enzymatic activity of superoxide dismutase (SOD) and prophenoloxidase (ProPO) did differ between the two treatments. The activities of both SOD and ProPO under the M. anisopliae treatment were lower than that in the controls, except for the ProPO activity at 72 h and the SOD activity at 96 h. Further, the expression of the L. migratoria immune-related genes defensin, spaetzle, and attacin differed after exposure to M. anisopliae for 24 h to 96 h. Taken together, this study indicated that infection with M. anisopliae CQMa421 could cause the death of L. migratoria by interacting with the immune responses of the host, demonstrating that this fungal strain of M. anisopliae can be an efficient biocontrol agent against L. migratoria.

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Section: Discussionmentioning

confidence: 99%

Effects of the Entomopathogenic Fungus Metarhizium anisopliae on the Mortality and Immune Response of Locusta migratoria

Jiang

Peng

et al. 2019

Insects

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“…However, biochemical abnormalities have been reported following exposure to NEOCs and may be linked to the previously mentioned disorders. In bees, increases in the acetylcholinesterase activity have been observed following exposure to NEOCs revealing its potential interest as a biomarker 11 , 12 . Also THM promotes oxidative stress in honey bees as shown by the increased activity of catalase and glutathione S-transferase 13 .…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to imidacloprid or thiamethoxam neonicotinoid causes oxidative damages and alters carotenoid-retinoid levels in caged honey bees (Apis mellifera)

Gauthier

Aras

Paquin

et al. 2018

Sci Rep

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Over the last decade, the persistent dwindling of the populations of honey bees has become a growing concern. While this phenomenon is partly attributed to neonicotinoids (NEOCs), chronic exposures to these insecticides at environmentally-relevant concentrations are needed to fully estimate their implications. In this study, honey bees were orally exposed for 10 days to low field-realistic concentrations of NEOCs known for their effects on the cholinergic system (imidacloprid – IMI or thiamethoxam – THM). Selected biomarkers were measured such as acetylcholinesterase (AChE) activity, lipid peroxidation (LPO), α-tocopherol as well as several forms of vitamin A (retinoids) and carotenoids. Bees exposed to IMI showed lower levels of two carotenoids (α-carotene and α-cryptoxanthin) and α-tocopherol. The THM exposure increased the oxidized vitamin A metabolites in bees conjointly with the LPO. These results could be the consequence of a pro-oxidant effect of NEOCs and were observed at levels where no effects were recorded for AChE activity. This study reveals that exposure to low levels of NEOCs alters the carotenoid-retinoid system in honey bees. This would merit further investigation as these compounds are important in various aspects of bees’ health. Overall, this study contributes to the development of biomonitoring tools for the health of bees and other pollinators.

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“…According to some observations, if during the treatment of apiaries is adjacent to the other apiaries, bees fly through the spray drift of the pesticide, and then they absorb with their bodies an odor different from the one specific to the hive [76,77]. Impacted individuals are, thus, not recognized by the bees guarding the bee colony, and, as a result of which, they are not allowed into the hive or are killed as invaders [78][79][80]. This circumstance further necessitates the strict application of the requirement to broadcast warnings locally before carrying out all chemical treatments-spraying, sowing of treated seeds, etc.…”

Section: Pesticides As a Factor In The Deterioration Of The Health Stmentioning

confidence: 99%

“…Exposure of bees to sublethal doses of pesticides occurs not only with systemic products (most commonly, aqueous solutions applied to vegetative plants) but also with non-systemics, such as pyrethroids and organophosphates, which can reduce the lifespan of individuals [75,76]. Recent studies have shown that low levels of intoxication-oral or contact, with active substances other than neonicotinoids-can weaken the immune system of exposed individuals, impair their ability to learn by monitoring and communicating with other bees, thus leading to memory loss and a change in their eating behavior and ability to distinguish flavors [72][73][74][75][76][77][78][79][80][81][82][83][84].…”

Section: Effect Of Pesticides (Other Than Neonicotinoids) On Bee Healthmentioning

confidence: 99%

Biotic and Abiotic Factors Associated with Colonies Mortalities of Managed Honey Bee (Apis mellifera)

et al. 2019

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Despite the presence of a large number of pollinators of flowering plants worldwide, the European honey bee, Apis melifera, plays the most important role in the pollination of a number of crops, including all vegetables, non-food crops and oilseed crops, decorative and medical plants, and others. The experience of isolated cases of complete extinction of honey bees in individual regions has shown that this phenomenon leads to a dramatic pollination crisis and reduced ability or even total inability to grow insect-pollinated crops if relying solely on native, naturally occurring pollinators. Current scientific data indicate that the global bee extinction between the Cretaceous and the Paleogene (Cretaceous-Tertiary) occurred, which led to the disappearance of flowers because they could not produce viable fruit and germinate due to lack of pollination by bees or other animals. From the Middle Ages to the present day, there has been evidence that honey bees have always overcome the adverse factors affecting them throughout the ages, after which their population has fully recovered. This fact must be treated with great care given the emergence of a new, widespread stress factor in the second half of the 20th century—intoxication of beehives with antibiotics and acaricides, and treatment of crops with pesticides. Along with acute and chronic intoxication of bees and bee products, there are other new major stressors of global importance reducing the number of bee colonies: widespread prevalence of pathogenic organisms and pest beetles, climate change and adverse climatic conditions, landscape changes and limitation of natural habitats, intensification of agricultural production, inadequate nutrition, and introduction of invasive species. This report summarizes the impact of individual negative factors on the health and behavior of bees to limit the combined effects of the above stressors.

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Differential physiological effects of neonicotinoid insecticides on honey bees: A comparison between Apis mellifera and Apis cerana

Cited by 81 publications

References 42 publications

Effects of the Entomopathogenic Fungus Metarhizium anisopliae on the Mortality and Immune Response of Locusta migratoria

Effects of the Entomopathogenic Fungus Metarhizium anisopliae on the Mortality and Immune Response of Locusta migratoria

Chronic exposure to imidacloprid or thiamethoxam neonicotinoid causes oxidative damages and alters carotenoid-retinoid levels in caged honey bees (Apis mellifera)

Biotic and Abiotic Factors Associated with Colonies Mortalities of Managed Honey Bee (Apis mellifera)

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