Differential perturbations of gut microbial profiles and co‐occurrence networks among phases of methamphetamine‐induced conditioned place preference

Wang, Yinan; Zhang, Jianbo; Deji, Cuola; Fan, Jingna; Miao, Xinyao; Li, Shuai Cheng; Zeng, Xiaofeng; Guan, Fanglin

doi:10.1002/jnr.24963

Cited by 11 publications

(10 citation statements)

References 42 publications

(48 reference statements)

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“…Evidence of METH-induced dysbiosis largely comes from observations using rodent models. Significant changes in the composition of gut microbiota have been found in rats and mice under different regimens of METH exposure ( Ning et al., 2017 ; Angoa-Pérez et al., 2020 ; Chen et al., 2021 ; Forouzan et al., 2021 ; Wang et al., 2021 ). Further, the alteration of Akkermansia has been identified to be associated with the rat’s behavioral response to METH in a conditioned place preference (CPP) model ( Yang C. et al., 2021 ), suggesting a possible role of gut microbiota in modulating METH-induced behavior and vulnerability to MUD.…”

Section: Introductionmentioning

confidence: 99%

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Deng

Song

et al. 2021

Front. Cell. Infect. Microbiol.

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Methamphetamine use disorder (MUD) is a major public health problem worldwide with limited effective treatment options. Previous studies have reported methamphetamine-associated alterations in gut microbiota. A potential role of gut microbiota in regulating methamphetamine-induced brain dysfunction through interactions with the host immune system has been proposed, but evidence for this hypothesis is limited. The present study aimed to investigate the alterations in the fecal microbiota and explore its relationship with systemic inflammation in MUD. Fecal samples were obtained from 26 male subjects with MUD and 17 sex- and age- matched healthy controls. Fecal microbial profiles were analyzed by 16S rRNA sequencing. Plasma inflammatory markers were measured using enzyme-linked immunosorbent assay. Associations between fecal microbiota, systemic inflammatory markers and clinical characteristics were examined by Spearman partial correlation analysis while controlling for possible confounders. Compared with healthy controls, individuals with MUD showed no difference in fecal microbial diversity, but exhibited differences in the relative abundance of several microbial taxa. At the genus level, a higher abundance of Collinsella, Odoribacter and Megasphaera and lower levels of Faecalibacterium, Blautia, Dorea and Streptococcus were detected in subjects with MUD. More importantly, altered fecal microbiota was found to be correlated with plasma levels of CRP, IL-2, IL-6 and IL-10. The order Lactobacillales, exhibiting lower abundance in participants with MUD, was positively related to the duration of methamphetamine abstinence and the plasma level of anti-inflammatory cytokine IL-10. This study is the first to provide evidence for a link between altered fecal microbiota and systemic inflammation in MUD. Further elucidation of interactions between gut microbiota and the host immune system may be beneficial for the development of novel therapeutic approaches for MUD.

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Section: Introductionmentioning

confidence: 99%

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Deng

Song

et al. 2021

Front. Cell. Infect. Microbiol.

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“…To exclude the effects of diet, age, and obesity on the intestinal flora, in our current study, we collected stool samples from age-and BMI-matched participants after two weeks of a common diet source in a compulsory drug rehabilitation center. Also, the detoxification treatment (i.e., no MA intake while the participants were residing in the detoxification center) may have altered some extent of the MA's effects on intestinal flora (Forouzan et al, 2020;Wang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…With the emergence of the "gut-brain axis," the influence of intestinal flora on the brain's physiological, behavioral, and cognitive functions has become a trendy research topic (Wang and Wang, 2016). Recent studies have demonstrated a strong link between MA use and gut microbiome (Ning et al, 2017;Cook et al, 2019;Angoa-Peŕez et al, 2020;Forouzan et al, 2020;Chen et al, 2021;Deng et al, 2021;Wang et al, 2021;Lai et al, 2022;Wang et al, 2022;. Clinical research has shown significant differences in the GM composition between MA users and non-MA users (Cook et al, 2019) and marked changes in GM among individuals with MUD related to their inflammatory markers and clinical characteristics (Deng et al, 2021;.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical research has shown significant differences in the GM composition between MA users and non-MA users (Cook et al, 2019) and marked changes in GM among individuals with MUD related to their inflammatory markers and clinical characteristics (Deng et al, 2021;. In animal studies, MA treatment disrupted the gut microbiome balance (Angoa-Peŕez et al, 2020;Forouzan et al, 2020;Chen et al, 2021), and MAinduced conditioned place preference (CPP) resulted in dramatic changes in the diversity and composition of the GM (Ning et al, 2017;Wang et al, 2021;. The GM continued to evolve during different phases of CPP, including acquisition, extinction, and reinstatement (Wang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…In animal studies, MA treatment disrupted the gut microbiome balance (Angoa-Peŕez et al, 2020;Forouzan et al, 2020;Chen et al, 2021), and MAinduced conditioned place preference (CPP) resulted in dramatic changes in the diversity and composition of the GM (Ning et al, 2017;Wang et al, 2021;. The GM continued to evolve during different phases of CPP, including acquisition, extinction, and reinstatement (Wang et al, 2021). These various lines of evidence suggest a potential link between GM and MUD development.…”

Section: Introductionmentioning

confidence: 99%

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Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder

Yang²,

Ma³

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundThe transition from methamphetamine (MA) casual use (MCU) to compulsive use is enigmatic as some MA users can remain in casual use, but some cannot. There is a knowledge gap if gut microbiota (GM) play a role in differing MCU from MA use disorder (MUD). We aimed to investigate the clinical features and GM differences between individuals with MCU and MUD.MethodWe recruited two groups of MA users –MCU and MUD – and matched them according to age and body mass index (n=21 in each group). Participants were accessed using the Semi-Structured Assessment for Drug Dependence and Alcoholism, and their fecal samples were undergone 16S ribosomal DNA sequencing. We compared the hosts’ clinical features and GM diversity, composition, and structure (represented by enterotypes) between the two groups. We have identified differential microbes between the two groups and performed network analyses connecting GM and the clinical traits.ResultCompared with the casual users, individuals with MUD had higher incidences of MA-induced neuropsychiatric symptoms (e.g., paranoia, depression) and withdrawal symptoms (e.g., fatigue, drowsiness, and increased appetite), as well as stronger cravings for and intentions to use MA, and increased MA tolerance. The GM diversity showed no significant differences between the two groups, but four genera (Halomonas, Clostridium, Devosia, and Dorea) were enriched in the individuals with MUD (p<0.05). Three distinct enterotypes were identified in all MA users, and Ruminococcus-driven enterotype 2 was dominant in individuals with MUD compared to the MCU (61.90% vs. 28.60%, p=0.03). Network analysis shows that Devosia is the hub genus (hub index = 0.75), which is not only related to the counts of the MUD diagnostic criteria (ρ=0.40; p=0.01) but also to the clinical features of MA users such as reduced social activities (ρ=0.54; p<0.01). Devosia is also associated with the increased intention to use MA (ρ=0.48; p<0.01), increased MA tolerance (ρ=0.38; p=0.01), craving for MA (ρ=0.37; p=0.01), and MA-induced withdrawal symptoms (p<0.05).ConclusionOur findings suggest that Ruminococcus-driven enterotype 2 and the genera Devosia might be two influential factors that differentiate MA casual use from MUD, but further studies are warranted.

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Alterations in gut microbiota affect behavioral and inflammatory responses to methamphetamine in mice

Lai

Wang

et al. 2022

Psychopharmacology

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Differential perturbations of gut microbial profiles and co‐occurrence networks among phases of methamphetamine‐induced conditioned place preference

Cited by 11 publications

References 42 publications

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder

Alterations in gut microbiota affect behavioral and inflammatory responses to methamphetamine in mice

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