Differential Peripheral Inflammatory Factors Associated with Cognitive Function in Patients with Heart Failure

Redwine, Laura; Pung, Meredith A.; Wilson, Kathleen; Chinh, Kelly; Duffy, Allyson

doi:10.1159/000493142

Cited by 8 publications

(9 citation statements)

References 45 publications

(60 reference statements)

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“… 55 In patients with Alzheimer disease, there is a meaningful correlation between inflammatory mediators and GCF. 56 57 Moreover, it has been shown that the plasma of patients with COPD often contains abnormal levels of inflammatory mediators, including IL-6, IL-8, CRP, TNF-α and BDNF. 58–60 Therefore, in this study, we seek to observe whether PR can affect GMV and blood inflammatory mediators and to explore the possible mechanism by which exercise affects cognitive function in patients with COPD.…”

Section: Discussionmentioning

confidence: 99%

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

Duan

Wang

et al. 2020

BMJ Open

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IntroductionCognitive impairment, an important complication in patients with chronic obstructive pulmonary disease (COPD), seriously affects self-management of the disease and quality of life (QoL). As an exercise-based intervention programme, pulmonary rehabilitation (PR)—especially aerobic exercise (mainly mind–body exercise) and resistance exercise (RE)—has been proposed for its potential effectiveness in improving cognitive function. However, there is still a lack of strong evidence for PR’s effectiveness. In this study, we expect to clarify the effects of pulmonary-based Qigong exercise and elastic band-based RE on cognitive function in patients with COPD and to fill in the relevant evidence blanks.Methods and analysisThis study is a single-centre randomised controlled trial with assessor and data analyst blinding. We will recruit 108 participants with stable COPD starting on 23 December 2019, and randomly allocate them into the pulmonary-based Qigong exercise group, elastic band-based RE group, pulmonary-based Qigong exercise and elastic band-based RE combined group, or control group at a 1:1:1:1 ratio. Participants in intervention groups will perform 30 min of exercise two times per day, 5 days a week, for 12 weeks. The primary outcome will be the global cognitive function as assessed by the Montreal Cognitive Assessment and auditory event-related potential P300. Secondary outcomes will include the specific cognitive domains—attention, memory, executive function, verbal fluency and mental-processing speed; psychological functions and QoL. Exploratory outcomes will include grey matter volume and levels of inflammatory mediators. Outcomes will be measured before and after the interventions.Ethics and disseminationEthics approval has been granted by the Ethics Committee of Yue-Yang Integrative Medicine Hospital, an affiliate of Shanghai University of Traditional Chinese Medicine, Shanghai, China (Grant No. 2019-141). Written informed consent will be obtained from each participant before any procedures are performed. The findings will be published in peer-reviewed journals and presented at academic conferences.Trial registration numberChiCTR1900026869; pre-results.

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Section: Discussionmentioning

confidence: 99%

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

Duan

Wang

et al. 2020

BMJ Open

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“…For example, our previous cross-sectional study revealed that patients with HF and MCI had greater circulating peripheral vascular inflammation marker levels compared to patients without MCI (27). Another study found a negative relationship between peripheral inflammation biomarkers, C-reactive protein (CRP) and interleukin-6 (IL-6), and cognitive function in patients with HF (28).…”

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confidence: 99%

An exploratory randomized sub-study of light-to-moderate intensity exercise on cognitive function, depression symptoms and inflammation in older adults with heart failure

Redwine

Pung

Wilson

et al. 2020

Journal of Psychosomatic Research

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Almost half of patients with heart failure (HF) have cognitive impairment. While exercise relates to better cognitive health, a hallmark of HF is exercise intolerance. The study objective was to explore whether light-to-moderate exercise improves cognitive function in patients with HF. Methods: This was an exploratory parallel design study of 69 patients with symptomatic HF (mean age=65, SD = 10), recruited from VA and University of California, San Diego Healthcare Systems. Participants were randomized to Tai Chi (TC) (n = 24), resistance band (RB) exercise (n = 22) or treatment as usual (TAU) (n = 23). The primary outcome was change in Montreal Cognitive Assessment (MoCA) scores. We further explored if changes in Beck Depression Inventory -IA (BDI-IA) scores or inflammation biomarkers, CRP, TNFα and IL-6 related to altered cognitive function. Results: There was a fixed effect of group for MoCA scores changes (F = 8.07, p = .001). TC and RB groups had greater MoCA score increases versus TAU, but no differences were found between TC and RB. Depression symptom changes predicted altered MoCA scores (ΔR 2 = .15, Δ = −.413, p = .001). However, group did not interact with depression symptom levels for MoCA alterations (p = .392). Changes in CRP levels predicted MoCA scores (ΔR 2 = .078, Δ = −.283, p = .01), but group did not interact with CRP levels for MoCA alterations (p = .689). Conclusions: Light-to-moderate exercises, TC and RB may improve cognitive function. However, the mechanisms remain unclear. ClinicalTrials.gov: NCT01625819 Heart failure (HF) affects approximately 6.5 million adults in the United States (1). Fifty percent of patients with HF and 90% of all HF deaths occur in adults over 70 years of age (2). With age, diminishing cardio-protective and repair systems associated with adverse *

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“…Cardiovascular disease (CVD) is a common chronic condition that disproportionately affects older adults [1]. Prior studies have shown a connection between CVD and cognitive impairment [2][3][4][5][6][7][8], with multiple potential mechanisms at play, including atherosclerotic-related cerebrovascular disease (causing cerebral hypoxia, brain infarctions, and damage to the blood-brain barrier) [9][10][11]; oxidative stress and inflammatory immune responses [12,13]; and thromboembolism from concomitant atrial fibrillation [14,15]. More recently, several longitudinal studies have indicated that incident CVD is associated with an acceleration in the decline in memory and processing speed that occurs normally with age [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular disease and cumulative incidence of cognitive impairment in the Health and Retirement Study

Covello

Horwitz²,

Singhal

et al. 2021

BMC Geriatr

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Background We sought to examine whether people with a diagnosis of cardiovascular disease (CVD) experienced a greater incidence of subsequent cognitive impairment (CI) compared to people without CVD, as suggested by prior studies, using a large longitudinal cohort. Methods We employed Health and Retirement Study (HRS) data collected biennially from 1998 to 2014 in 1305 U.S. adults age ≥ 65 newly diagnosed with CVD vs. 2610 age- and gender-matched controls. Diagnosis of CVD was adjudicated with an established HRS methodology and included self-reported coronary heart disease, angina, heart failure, myocardial infarction, or other heart conditions. CI was defined as a score < 11 on the 27-point modified Telephone Interview for Cognitive Status. We examined incidence of CI over an 8-year period using a cumulative incidence function accounting for the competing risk of death. Results Mean age at study entry was 73 years, 55% were female, and 13% were non-white. Cognitive impairment developed in 1029 participants over 8 years. The probability of death over the study period was greater in the CVD group (19.8% vs. 13.8%, absolute difference 6.0, 95% confidence interval 2.2 to 9.7%). The cumulative incidence analysis, which adjusted for the competing risk of death, showed no significant difference in likelihood of cognitive impairment between the CVD and control groups (29.7% vs. 30.6%, absolute difference − 0.9, 95% confidence interval − 5.6 to 3.7%). This finding did not change after adjusting for relevant demographic and clinical characteristics using a proportional subdistribution hazard regression model. Conclusions Overall, we found no increased risk of subsequent CI among participants with CVD (compared with no CVD), despite previous studies indicating that incident CVD accelerates cognitive decline.

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Differential Peripheral Inflammatory Factors Associated with Cognitive Function in Patients with Heart Failure

Cited by 8 publications

References 45 publications

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

An exploratory randomized sub-study of light-to-moderate intensity exercise on cognitive function, depression symptoms and inflammation in older adults with heart failure

Cardiovascular disease and cumulative incidence of cognitive impairment in the Health and Retirement Study

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